Podcast
Questions and Answers
Hematology analyzers use only Coulter's principle to identify blood cells.
Hematology analyzers use only Coulter's principle to identify blood cells.
False
Hematology analyzers are only used to conduct a complete blood count.
Hematology analyzers are only used to conduct a complete blood count.
False
The first hematology analyzer was engineered by Wallace H. Coulter.
The first hematology analyzer was engineered by Wallace H. Coulter.
True
A complete blood count includes only red blood cell and white blood cell counts.
A complete blood count includes only red blood cell and white blood cell counts.
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A 3-part differential cell counter can differentiate between five types of white blood cells.
A 3-part differential cell counter can differentiate between five types of white blood cells.
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Laboratory technicians still count blood cells individually underneath a microscope.
Laboratory technicians still count blood cells individually underneath a microscope.
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Hematology analyzers can measure platelet distribution width and platelet mean volume.
Hematology analyzers can measure platelet distribution width and platelet mean volume.
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Hematology analyzers are used only in research settings.
Hematology analyzers are used only in research settings.
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Study Notes
Hematology Analyzers
- Used to count and identify blood cells at high speed with accuracy, replacing manual counting under a microscope in the 1950s
- First analyzer engineered by Wallace H. Coulter, relying on Coulter's principle (Coulter counter)
Uses of Hematology Analyzers
- Conduct complete blood count (CBC) to determine patient's general health status
- CBC includes: red blood cell (RBC) count, white blood cell (WBC) count, hemoglobin, platelet count, and hematocrit levels
- Other analyses include:
- RBC distribution width
- Mean corpuscular volume
- Mean corpuscular hemoglobin
- Mean corpuscular hemoglobin concentrations
- WBC differential count in percentage and absolute value
- Platelet distribution width
- Platelet mean volume
- Large platelet cell ratio
- Platelet criteria
Techniques Used
- Flow cytometry
- Spectrophotometry
- Electrical impedance (Coulter's principle)
- Digital microscopy with AI
Types of Hematology Analyzers
3-Part Differential Cell Counter
- Uses Coulter's principle to find the size and volume of cells
- Differentiates between three types of white blood cells (WBCs): neutrophils, lymphocytes, and monocytes
5-Part Differential Cell Counter
- Utilizes both Coulter's principle and flow cytometry to determine cell granularity, diameter, and inner complexity
- Differentiates all WBC types: neutrophils, lymphocytes, basophils, eosinophils, and monocytes
Components of Hematology Analyzer
- Power source
- Control unit
- Collecting system
- Data storage
- Processing system
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Description
Learn about the evolution of hematology analyzers, from manual counting to automated machines, and how they revolutionized blood cell counting.
