Podcast
Questions and Answers
What was the method used to count blood cells in the 1950s?
What was the method used to count blood cells in the 1950s?
Who engineered the first basic hematology analyzer?
Who engineered the first basic hematology analyzer?
What is the typical first test requested by physicians to determine a patient's general health status?
What is the typical first test requested by physicians to determine a patient's general health status?
What is not included in a complete blood count?
What is not included in a complete blood count?
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What principle do early hematology analyzers rely on?
What principle do early hematology analyzers rely on?
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What type of cell counter uses Coulter's principle to find the size and volume of cells?
What type of cell counter uses Coulter's principle to find the size and volume of cells?
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What is the primary function of a hematology analyzer?
What is the primary function of a hematology analyzer?
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What is the purpose of a complete blood count?
What is the purpose of a complete blood count?
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Study Notes
Hematology Analyzers
- Used to count and identify blood cells at high speed with accuracy, replacing manual counting under a microscope in the 1950s
- First analyzer engineered by Wallace H. Coulter, relying on Coulter's principle (Coulter counter)
Uses of Hematology Analyzers
- Conduct complete blood count (CBC) to determine patient's general health status
- CBC includes: red blood cell (RBC) count, white blood cell (WBC) count, hemoglobin, platelet count, and hematocrit levels
- Other analyses include:
- RBC distribution width
- Mean corpuscular volume
- Mean corpuscular hemoglobin
- Mean corpuscular hemoglobin concentrations
- WBC differential count in percentage and absolute value
- Platelet distribution width
- Platelet mean volume
- Large platelet cell ratio
- Platelet criteria
Techniques Used
- Flow cytometry
- Spectrophotometry
- Electrical impedance (Coulter's principle)
- Digital microscopy with AI
Types of Hematology Analyzers
3-Part Differential Cell Counter
- Uses Coulter's principle to find the size and volume of cells
- Differentiates between three types of white blood cells (WBCs): neutrophils, lymphocytes, and monocytes
5-Part Differential Cell Counter
- Utilizes both Coulter's principle and flow cytometry to determine cell granularity, diameter, and inner complexity
- Differentiates all WBC types: neutrophils, lymphocytes, basophils, eosinophils, and monocytes
Components of Hematology Analyzer
- Power source
- Control unit
- Collecting system
- Data storage
- Processing system
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Description
Learn about the evolution of hematology analyzers from manual counting to automated systems, and how they identify blood cells with high speed and accuracy.
