Hallmark 1 - Replicative Immortality in Cancer

Play an AI-generated podcast conversation about this lesson

What is the main difference in the metabolism of normal cells compared to cancer cells?

Cancer cells break down glucose to pyruvate to produce ATP. (correct)

Normal cells can proliferate due to overactive oncogenes.

Cancer cells divert metabolites for energy production through glycolysis.

Normal cells convert glucose to lactate regardless of oxygen levels.

Which characteristic distinguishes cancer cells from normal cells in terms of immune response avoidance?

Cancer cells inhibit T cells by secreting antibodies and cytokines.

Cancer cells express PDL-1 or PDL-2 antigens to deflect the immune response. (correct)

Cancer cells stimulate the immune system to destroy foreign particles.

Cancer cells have a higher sensitivity to DNA damage.

What ability do cancer cells possess that allows them to survive and grow by inducing the formation of new blood vessels?

Cancer cells can break through the extracellular matrix during invasion.

Cancer cells can over-activate oncogenes.

Cancer cells possess an altered metabolism.

Cancer cells can induce angiogenesis to create new blood vessels. (correct)

How do cancer cells differ from normal cells in terms of proliferation?

Cancer cells proliferate due to over-active oncogenes. Signup and view all the answers

What is the main function of having PDL-1 or PDL-2 antigens in cancer cells?

To inhibit T cells from attacking cancer cells. Signup and view all the answers

How do cancer cells differ from normal cells in terms of their interaction with the immune system?

Cancer cells inhibit T cells that would normally attack them. Signup and view all the answers

What characteristic of cancer cells allows them to greatly exceed Hayflick's limit?

Elongating their telomeres using telomerase Signup and view all the answers

Which gene acts as a central regulator of cell death by halting the cell cycle in response to DNA damage?

Tumor suppressor gene p53 Signup and view all the answers

How do most cancer cells avoid normal growth suppressor signals in the G1 checkpoint?

By carrying mutations in tumor suppressor genes Signup and view all the answers

What hallmark of cancer involves the ability of cancer cells to bear mutations in their DNA and still undergo mitosis?

Genome instability Signup and view all the answers

Which enzyme is responsible for elongating chromosomal ends (telomeres) in cancer cells?

Telomerase Signup and view all the answers

In normal human cells, what phase of the cell cycle do cells enter after reaching Hayflick's limit?

G0 phase Signup and view all the answers

Hallmark 1 - Replicative Immortality in Cancer

Podcast Beta

Questions and Answers

What is the main difference in the metabolism of normal cells compared to cancer cells?

Which characteristic distinguishes cancer cells from normal cells in terms of immune response avoidance?

What ability do cancer cells possess that allows them to survive and grow by inducing the formation of new blood vessels?

How do cancer cells differ from normal cells in terms of proliferation?

What is the main function of having PDL-1 or PDL-2 antigens in cancer cells?

How do cancer cells differ from normal cells in terms of their interaction with the immune system?

What characteristic of cancer cells allows them to greatly exceed Hayflick's limit?

Which gene acts as a central regulator of cell death by halting the cell cycle in response to DNA damage?

How do most cancer cells avoid normal growth suppressor signals in the G1 checkpoint?

What hallmark of cancer involves the ability of cancer cells to bear mutations in their DNA and still undergo mitosis?

Which enzyme is responsible for elongating chromosomal ends (telomeres) in cancer cells?

In normal human cells, what phase of the cell cycle do cells enter after reaching Hayflick's limit?

More Like This

Hallmark 1: Replicative Immortality in Cancer Cells

Replicative Cycles of Animal Viruses

Cell Biology: Clonality and Replicative Capacity

Sénescence partie 1

Upgrade to continue