RNA-Mediated Transposition Prediction Exercise

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What is the flow of Ty-1 sequence information during transposition?

DNA to DNA to RNA
RNA to DNA to RNA
RNA to DNA to Protein
DNA to RNA to DNA (correct)

What can transposable elements cause in the genome?

Increasing the size of genes
Deleting all genes
Additional rearrangements (correct)
Enhancing gene regulation

What is the outcome of recombination between two transposable elements in the same orientation?

Inversion
Deletion (correct)
Duplication
Translation

What is the predicted mechanism if yeast Ty-1 moved as illustrated for DNA-mediated replicative transposition?

RNA-mediated transposition (A) Signup and view all the answers

What happens if recombination occurs between two transposable elements in opposite orientations?

Inversion (B) Signup and view all the answers

Does the retrotransposition machinery have an absolute preference for LINE1 mRNA?

No, the preference is not absolute (D) Signup and view all the answers

What is the primary defining feature of transposons?

They can move from one genetic location to another. (B) Signup and view all the answers

Which type of cells contain transposons?

Both prokaryotic and eukaryotic cells (D) Signup and view all the answers

What is one role of transposases in the transposition process?

Catalyzing the movement of transposons (A) Signup and view all the answers

How do transposons cause genetic mutations?

By adding new genetic material (C) Signup and view all the answers

Which statement accurately describes transposons in the human genome?

They constitute approximately 50 to 65% of the genome. (A) Signup and view all the answers

What distinguishes the two major classes of transposable elements?

The intermediates involved in the transposition process (A) Signup and view all the answers

What is the main difference between replicative and nonreplicative transposition?

DNA synthesis occurs at the crossover structure in replicative transposition but not in nonreplicative transposition. (A) Signup and view all the answers

How does replicative transposition differ from nonreplicative transposition in terms of DNA synthesis?

DNA synthesis results in a copy at both donor and target sites in replicative transposition. (A) Signup and view all the answers

What is the significance of the strand-transfer intermediate in transposition?

It attaches the transposable element to both donor and recipient replicons. (C) Signup and view all the answers

How does nonreplicative transposition differ from replicative transposition in terms of cointegrate intermediate formation?

Cointegrate intermediate is produced through DNA synthesis in replicative transposition. (A) Signup and view all the answers

What happens to the transposon in an alternative pathway for nonreplicative transposition?

It is joined to the recipient at a staggered break. (C) Signup and view all the answers

What is common between replicative and nonreplicative transposition regarding generating the strand-transfer intermediate?

DNA synthesis occurs at this stage for both types of transposition. (A) Signup and view all the answers