Hallmark 1: Replicative Immortality in Cancer Cells
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Questions and Answers

What is the hallmark associated with cancer cells converting glucose to lactate irrespective of oxygen?

  • Hallmark 6 - Altered Metabolism (correct)
  • Hallmark 7 - Avoiding Immune Destruction
  • Hallmark 5 - Sustained Proliferation
  • Hallmark 8 - Tumor Promoting Inflammation

Which immune cell type do cancer cells inhibit to avoid immune destruction?

  • B cells
  • Macrophages
  • Natural killer cells
  • T lymphocytes (correct)

What process do tumor cells induce to survive by creating new blood vessels from pre-existing ones?

  • Metastasis
  • Angiogenesis (correct)
  • Apoptosis
  • Glycolysis

How do normal cells react to abundant DNA damage and stress compared to cancer cells?

<p>Normal cells initiate apoptosis (A)</p> Signup and view all the answers

Which hallmark describes the ability of cancer cells to divert metabolites for useful processes such as mitosis?

<p>Hallmark 6 - Altered Metabolism (A)</p> Signup and view all the answers

What factor allows tumor cells to break through the extracellular matrix during invasion?

<p>Over-active oncogenes (C)</p> Signup and view all the answers

What characteristic allows cancer cells to greatly exceed the Hayflick's limit and continue to undergo mitosis?

<p>Elongation of telomeres using telomerase (B)</p> Signup and view all the answers

What is a key characteristic of cancer cells related to Genome Instability?

<p>Possessing an abnormal number of chromosomes per cell (A)</p> Signup and view all the answers

Which gene functions as a central regulator of cell death by stopping the cell cycle upon detection of DNA damage?

<p>p53 Tumor Suppressor Gene (B)</p> Signup and view all the answers

Why do most cancer cells avoid normal growth suppressor signals in the G1 checkpoint?

<p>To continue proliferating (D)</p> Signup and view all the answers

What mechanism allows cancer cells to resist cell death?

<p>Being able to evade apoptosis (B)</p> Signup and view all the answers

What is the enzyme that cancer cells use to elongate their telomeres?

<p>Telomerase (C)</p> Signup and view all the answers

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