12 Questions
What is the hallmark associated with cancer cells converting glucose to lactate irrespective of oxygen?
Hallmark 6 - Altered Metabolism
Which immune cell type do cancer cells inhibit to avoid immune destruction?
T lymphocytes
What process do tumor cells induce to survive by creating new blood vessels from pre-existing ones?
Angiogenesis
How do normal cells react to abundant DNA damage and stress compared to cancer cells?
Normal cells initiate apoptosis
Which hallmark describes the ability of cancer cells to divert metabolites for useful processes such as mitosis?
Hallmark 6 - Altered Metabolism
What factor allows tumor cells to break through the extracellular matrix during invasion?
Over-active oncogenes
What characteristic allows cancer cells to greatly exceed the Hayflick's limit and continue to undergo mitosis?
Elongation of telomeres using telomerase
What is a key characteristic of cancer cells related to Genome Instability?
Possessing an abnormal number of chromosomes per cell
Which gene functions as a central regulator of cell death by stopping the cell cycle upon detection of DNA damage?
p53 Tumor Suppressor Gene
Why do most cancer cells avoid normal growth suppressor signals in the G1 checkpoint?
To continue proliferating
What mechanism allows cancer cells to resist cell death?
Being able to evade apoptosis
What is the enzyme that cancer cells use to elongate their telomeres?
Telomerase
Explore the concept of replicative immortality in cancer cells, which enables them to continue dividing beyond the normal limit of human cells. Learn about the role of telomeres in regulating mitosis and how cancer cells evade this mechanism.
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