Hallmark 1: Replicative Immortality in Cancer Cells

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What is the hallmark associated with cancer cells converting glucose to lactate irrespective of oxygen?

Hallmark 6 - Altered Metabolism (correct)

Hallmark 7 - Avoiding Immune Destruction

Hallmark 5 - Sustained Proliferation

Hallmark 8 - Tumor Promoting Inflammation

Which immune cell type do cancer cells inhibit to avoid immune destruction?

B cells

Macrophages

Natural killer cells

T lymphocytes (correct)

What process do tumor cells induce to survive by creating new blood vessels from pre-existing ones?

Metastasis

Angiogenesis (correct)

Apoptosis

Glycolysis

How do normal cells react to abundant DNA damage and stress compared to cancer cells?

Normal cells initiate apoptosis Signup and view all the answers

Which hallmark describes the ability of cancer cells to divert metabolites for useful processes such as mitosis?

Hallmark 6 - Altered Metabolism Signup and view all the answers

What factor allows tumor cells to break through the extracellular matrix during invasion?

Over-active oncogenes Signup and view all the answers

What characteristic allows cancer cells to greatly exceed the Hayflick's limit and continue to undergo mitosis?

Elongation of telomeres using telomerase Signup and view all the answers

What is a key characteristic of cancer cells related to Genome Instability?

Possessing an abnormal number of chromosomes per cell Signup and view all the answers

Which gene functions as a central regulator of cell death by stopping the cell cycle upon detection of DNA damage?

p53 Tumor Suppressor Gene Signup and view all the answers

Hallmark 1: Replicative Immortality in Cancer Cells

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Questions and Answers

What is the hallmark associated with cancer cells converting glucose to lactate irrespective of oxygen?

Which immune cell type do cancer cells inhibit to avoid immune destruction?

What process do tumor cells induce to survive by creating new blood vessels from pre-existing ones?

How do normal cells react to abundant DNA damage and stress compared to cancer cells?

Which hallmark describes the ability of cancer cells to divert metabolites for useful processes such as mitosis?

What factor allows tumor cells to break through the extracellular matrix during invasion?

What characteristic allows cancer cells to greatly exceed the Hayflick's limit and continue to undergo mitosis?

What is a key characteristic of cancer cells related to Genome Instability?

Which gene functions as a central regulator of cell death by stopping the cell cycle upon detection of DNA damage?

Why do most cancer cells avoid normal growth suppressor signals in the G1 checkpoint?

What mechanism allows cancer cells to resist cell death?

What is the enzyme that cancer cells use to elongate their telomeres?

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