GPCR Ligand Complexes and Classifications
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Questions and Answers

Which class of GPCRs is represented by the structure with PDB ID 3QAK?

  • Class C GPCRs
  • Class B GPCRs
  • Class A nonrhodopsin GPCRs (correct)
  • Class F GPCRs
  • What color are the antagonists represented as in the crystal structures?

  • Yellow
  • Red
  • Purple (correct)
  • Blue
  • How many transmembrane segments are present in Class A/Rhodopsin family GPCRs?

  • Seven (correct)
  • Three
  • Five
  • Nine
  • Which ligand-binding site is represented by the structure with PDB ID 4OR2?

    <p>mGlu1 R</p> Signup and view all the answers

    What do the first subdomain residues of the NR interact with?

    <p>The DNA major groove</p> Signup and view all the answers

    In addition to base-specific contacts with the DNA major groove, what do some NRs like LRH-1 and GCNF also contain?

    <p>C-terminal extensions (CTEs) for base-specific contacts with the minor groove</p> Signup and view all the answers

    What is the size of the ligand binding pocket in PPARg?

    <p>Very large</p> Signup and view all the answers

    What is noted about the differences between unliganded and ligand-bound receptors?

    <p>The liganded structures are more compact</p> Signup and view all the answers

    What is the common structure of class C GPCRs?

    <p>Two lobes separating binding of orthosteric and allosteric sites</p> Signup and view all the answers

    What marked the beginning of GPCR structural biology?

    <p>Crystal structure for bovine rhodopsin in 1983</p> Signup and view all the answers

    What did the first crystal structures for GPCR class C receptors enhance?

    <p>Interaction of ECDs and change in orientation of TMD</p> Signup and view all the answers

    Which subfamily do the solved 2D crystals belong to?

    <p>Class A</p> Signup and view all the answers

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