GPCR Ligand Complexes and Classifications

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Which class of GPCRs is represented by the structure with PDB ID 3QAK?

Class C GPCRs

Class B GPCRs

Class A nonrhodopsin GPCRs (correct)

Class F GPCRs

What color are the antagonists represented as in the crystal structures?

Yellow

Red

Purple (correct)

Blue

How many transmembrane segments are present in Class A/Rhodopsin family GPCRs?

Seven (correct)

Three

Five

Nine

Which ligand-binding site is represented by the structure with PDB ID 4OR2?

mGlu1 R Signup and view all the answers

What do the first subdomain residues of the NR interact with?

The DNA major groove Signup and view all the answers

In addition to base-specific contacts with the DNA major groove, what do some NRs like LRH-1 and GCNF also contain?

C-terminal extensions (CTEs) for base-specific contacts with the minor groove Signup and view all the answers

What is the size of the ligand binding pocket in PPARg?

Very large Signup and view all the answers

What is noted about the differences between unliganded and ligand-bound receptors?

The liganded structures are more compact Signup and view all the answers

What is the common structure of class C GPCRs?

Two lobes separating binding of orthosteric and allosteric sites Signup and view all the answers

What marked the beginning of GPCR structural biology?

Crystal structure for bovine rhodopsin in 1983 Signup and view all the answers

What did the first crystal structures for GPCR class C receptors enhance?

Interaction of ECDs and change in orientation of TMD Signup and view all the answers

Which subfamily do the solved 2D crystals belong to?

Class A Signup and view all the answers

GPCR Ligand Complexes and Classifications

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Questions and Answers

Which class of GPCRs is represented by the structure with PDB ID 3QAK?

What color are the antagonists represented as in the crystal structures?

How many transmembrane segments are present in Class A/Rhodopsin family GPCRs?

Which ligand-binding site is represented by the structure with PDB ID 4OR2?

What do the first subdomain residues of the NR interact with?

In addition to base-specific contacts with the DNA major groove, what do some NRs like LRH-1 and GCNF also contain?

What is the size of the ligand binding pocket in PPARg?

What is noted about the differences between unliganded and ligand-bound receptors?

What is the common structure of class C GPCRs?

What marked the beginning of GPCR structural biology?

What did the first crystal structures for GPCR class C receptors enhance?

Which subfamily do the solved 2D crystals belong to?

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