GPCR Signaling and Gene Transcription Activation Quiz

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What is the unique structure of the AtRGS1 protein?

It has an N-terminus resembling G protein-coupled receptor and an intrinsic GTPase activity

It has an N-terminus resembling GTPase and an intrinsic 7TM receptor activity

It has an N-terminus resembling 7TM receptor and an intrinsic GTPase activity (correct)

It has an N-terminus resembling RhoA receptor and an intrinsic ATPase activity

Which domain is involved in coupling the binding of semaphorin Sema4D to RhoA activation?

Sema domain (correct)

IPT domain

GGL domain

PSI domain

Which RGS protein was recently identified and is the shortest RGS protein?

RGS11

RGS2

RGS22

RGS21 (correct)

In which organisms were RGS1 and RGS2 discovered?

Saccharomyces cerevisiae, Aspergillus, and humans Signup and view all the answers

Which domain is found in plexins, Met and Ron tyrosine kinase receptors, and intracellular transcription factors?

IPT domain Signup and view all the answers

Which protein binds Gβ5 via its GGL domain?

RGS11 Signup and view all the answers

What is the ligand most likely for the 7TM portion of AtRGS1?

A simple sugar Signup and view all the answers

In which organisms were FlbA and RGS1 discovered?

Aspergillus and Caenorhabditis elegans Signup and view all the answers

What is the role of p-CREB in gene transcription?

It assembles the RNA Pol II transcription machinery Signup and view all the answers

What is the function of Gaq proteins in GPCR signaling?

Conducting the signal from the GPCR to PLCb Signup and view all the answers

What is the enzyme responsible for cleaving phosphatidylinositol 4,5-bisphosphate (PIP2)?

Phospholipase C (PLCb) Signup and view all the answers

What is the role of IP3 in GPCR signaling?

It triggers the opening of IP3-gated Ca2+ channels Signup and view all the answers

What is the function of diacylglycerol (DAG) in GPCR signaling?

Activating protein kinase C (PKC) Signup and view all the answers

Which protein binds to CREB to help assemble the RNA Pol II transcription machinery at promoters?

CBP/p300 Signup and view all the answers

What is the main second messenger formed as a result of phospholipase C (PLCb) activity?

Inositol 1,4,5-trisphosphate (IP3) Signup and view all the answers

Where does IP3 bind and trigger the opening of calcium channels?

Cytoplasmic membrane Signup and view all the answers

What is the effect of the binding of ACH to the Muscarinic Acetylcholine Receptor?

Triggering dissociation of Gai-GTP from Gßg Signup and view all the answers

What contributes to the termination of signaling by a GPCR, such as Galpha s signaling?

Hydrolysis of GTP by Gas enhanced by GAPS Signup and view all the answers

Which protein is involved in receptor down regulation?

RGS proteins Signup and view all the answers

What is the role of G protein-coupled receptor kinases?

Desensitization of receptor Signup and view all the answers

Which protein directly binds to and opens a K+ channel when ACH binds to the Muscarinic Acetylcholine Receptor?

Gai-GTP Signup and view all the answers

What contributes to the hyperpolarization of cells in the SA node when ACH binds to the Muscarinic Acetylcholine Receptor?

Movement of K+ down its concentration gradient to the outside of the cell Signup and view all the answers

What is the effect of ACH binding to the Muscarinic Acetylcholine Receptor on heart rate?

Hyperpolarization leading to a decrease in heart rate Signup and view all the answers

What is the role of HDAC5 in G signaling?

Regulation of ion channels Signup and view all the answers