GPCR Signaling and Gene Transcription Activation Quiz

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Questions and Answers

What is the unique structure of the AtRGS1 protein?

  • It has an N-terminus resembling G protein-coupled receptor and an intrinsic GTPase activity
  • It has an N-terminus resembling GTPase and an intrinsic 7TM receptor activity
  • It has an N-terminus resembling 7TM receptor and an intrinsic GTPase activity (correct)
  • It has an N-terminus resembling RhoA receptor and an intrinsic ATPase activity

Which domain is involved in coupling the binding of semaphorin Sema4D to RhoA activation?

  • Sema domain (correct)
  • IPT domain
  • GGL domain
  • PSI domain

Which RGS protein was recently identified and is the shortest RGS protein?

  • RGS11
  • RGS2
  • RGS22
  • RGS21 (correct)

In which organisms were RGS1 and RGS2 discovered?

<p>Saccharomyces cerevisiae, Aspergillus, and humans (C)</p> Signup and view all the answers

Which domain is found in plexins, Met and Ron tyrosine kinase receptors, and intracellular transcription factors?

<p>IPT domain (B)</p> Signup and view all the answers

Which protein binds Gβ5 via its GGL domain?

<p>RGS11 (A)</p> Signup and view all the answers

What is the ligand most likely for the 7TM portion of AtRGS1?

<p>A simple sugar (A)</p> Signup and view all the answers

In which organisms were FlbA and RGS1 discovered?

<p>Aspergillus and Caenorhabditis elegans (B)</p> Signup and view all the answers

What is the role of p-CREB in gene transcription?

<p>It assembles the RNA Pol II transcription machinery (A)</p> Signup and view all the answers

What is the function of Gaq proteins in GPCR signaling?

<p>Conducting the signal from the GPCR to PLCb (C)</p> Signup and view all the answers

What is the enzyme responsible for cleaving phosphatidylinositol 4,5-bisphosphate (PIP2)?

<p>Phospholipase C (PLCb) (A)</p> Signup and view all the answers

What is the role of IP3 in GPCR signaling?

<p>It triggers the opening of IP3-gated Ca2+ channels (C)</p> Signup and view all the answers

What is the function of diacylglycerol (DAG) in GPCR signaling?

<p>Activating protein kinase C (PKC) (A)</p> Signup and view all the answers

Which protein binds to CREB to help assemble the RNA Pol II transcription machinery at promoters?

<p>CBP/p300 (D)</p> Signup and view all the answers

What is the main second messenger formed as a result of phospholipase C (PLCb) activity?

<p>Inositol 1,4,5-trisphosphate (IP3) (A)</p> Signup and view all the answers

Where does IP3 bind and trigger the opening of calcium channels?

<p>Cytoplasmic membrane (B)</p> Signup and view all the answers

What is the effect of the binding of ACH to the Muscarinic Acetylcholine Receptor?

<p>Triggering dissociation of Gai-GTP from Gßg (B)</p> Signup and view all the answers

What contributes to the termination of signaling by a GPCR, such as Galpha s signaling?

<p>Hydrolysis of GTP by Gas enhanced by GAPS (B)</p> Signup and view all the answers

Which protein is involved in receptor down regulation?

<p>RGS proteins (D)</p> Signup and view all the answers

What is the role of G protein-coupled receptor kinases?

<p>Desensitization of receptor (A)</p> Signup and view all the answers

Which protein directly binds to and opens a K+ channel when ACH binds to the Muscarinic Acetylcholine Receptor?

<p>Gai-GTP (D)</p> Signup and view all the answers

What contributes to the hyperpolarization of cells in the SA node when ACH binds to the Muscarinic Acetylcholine Receptor?

<p>Movement of K+ down its concentration gradient to the outside of the cell (C)</p> Signup and view all the answers

What is the effect of ACH binding to the Muscarinic Acetylcholine Receptor on heart rate?

<p>Hyperpolarization leading to a decrease in heart rate (B)</p> Signup and view all the answers

What is the role of HDAC5 in G signaling?

<p>Regulation of ion channels (C)</p> Signup and view all the answers

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