Cell Injury I

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson
Download our mobile app to listen on the go
Get App

Questions and Answers

Which of the following is a cause of cell stress mentioned in the text?

  • Aging
  • Hormonal stimulation
  • Hyperplasia
  • Infection (correct)

Which cellular adaptation is characterized by an increase in cell size?

  • Hyperplasia
  • Hypertrophy (correct)
  • Atrophy
  • Metaplasia

What is the mechanism that causes atrophy in cells?

  • Increased physical demand
  • Growth factor stimulation
  • Altered hormone levels
  • Decreased blood supply (correct)

Which of the following is an example of hypertrophy?

<p>Increased cardiac muscle cell size in the left ventricle (C)</p> Signup and view all the answers

What is the cellular adaptation characterized by an increase in mitosis resulting in a greater number of cells?

<p>Hyperplasia (B)</p> Signup and view all the answers

Which enzyme converts hydrogen peroxide to water and oxygen?

<p>Catalase (D)</p> Signup and view all the answers

Which term describes the abnormal increase in the number of cells in a tissue or organ?

<p>Hyperplasia (B)</p> Signup and view all the answers

What is the primary function of ATP in cells?

<p>All of the above (D)</p> Signup and view all the answers

Which of the following is NOT a possible cause or condition that can lead to cell stress and injury?

<p>Normal cell function (D)</p> Signup and view all the answers

What is the most toxic free radical species?

<p>Hydroxyl radical (D)</p> Signup and view all the answers

Which of the following is one of the 4 general principles that underlie our understanding of the steps in cell injury and pathogenesis?

<p>Ischemia (D)</p> Signup and view all the answers

Which of the following can lead to loss of ATP production in mitochondria?

<p>All of the above (D)</p> Signup and view all the answers

What are the 3 key biochemical events observed during most instances of cell injury?

<p>Decreased ATP production, increased Ca++ levels, decreased oxygen supply (D)</p> Signup and view all the answers

What is the primary cause of hydropic change in cells?

<p>Loss of sodium-potassium ATPase activity (C)</p> Signup and view all the answers

What is the downstream effect of dysregulation of intracellular Ca++ levels that leads to additional injury of various cellular components?

<p>Activation of proteases and lipases (B)</p> Signup and view all the answers

Which pigment is the end product of the degradation of hemoglobin from red blood cells?

<p>Bilirubin (D)</p> Signup and view all the answers

What condition is noticed when concentrations of bilirubin in the blood exceed 2.0 mg/dL?

<p>Jaundice (A)</p> Signup and view all the answers

What is the brown granules that accumulate in macrophages and parenchymal cells and is a hemoglobin-derived, iron-containing pigment?

<p>Hemosiderin (B)</p> Signup and view all the answers

What is the insoluble product of the cell's lifetime of free radical injury and other insults known as?

<p>Lipofuscin (B)</p> Signup and view all the answers

What are the 3 key biochemical events that may lead to damage in one or multiple compartments of the cell?

<p>Loss of function, ATP depletion, and increased intracellular calcium (A)</p> Signup and view all the answers

Which of the following is NOT a cellular target for free radical injury?

<p>Double strand breaks in DNA (C)</p> Signup and view all the answers

What is the most important target for free radical injury?

<p>Lipid peroxidation of membranes (C)</p> Signup and view all the answers

Which of the following is responsible for the breakage of membrane lipids?

<p>Lipid peroxidation (D)</p> Signup and view all the answers

What happens when free radicals attack double bonds in polyunsaturated fatty acids of membrane lipids?

<p>The double bonds break (C)</p> Signup and view all the answers

What are the breakage products of lipid peroxidation?

<p>Peroxides (A)</p> Signup and view all the answers

Which of the following is a characteristic of metaplasia?

<p>It is a change in the state of differentiation of a cell in response to a stress (D)</p> Signup and view all the answers

Which of the following is an example of metaplasia?

<p>Replacement of normal stratified squamous epithelium of the lower esophagus with a columnar epithelial cell type (C)</p> Signup and view all the answers

Which of the following is a cause of fatty change of the liver?

<p>All of the above (D)</p> Signup and view all the answers

Which of the following is an example of an accumulation of protein in cells?

<p>Accumulation of proteins in proximal tubule cells of the kidney (D)</p> Signup and view all the answers

Which of the following is a characteristic of atheroma?

<p>Accumulation of lipids in the intimal thickenings of vessels (B)</p> Signup and view all the answers

Which of the following is a correct statement about metaplasia?

<p>Metaplasia is the conversion of one type of cell into another type of cell. (C)</p> Signup and view all the answers

Which of the following is an example of metaplasia?

<p>Replacement of normal stratified squamous epithelium of the lower esophagus with a columnar epithelial cell type. (B)</p> Signup and view all the answers

What is the term for the accumulation of triglycerides in hepatocytes?

<p>Fatty change of the liver (C)</p> Signup and view all the answers

Which of the following is a correct statement about accumulations in cells?

<p>Accumulations can be normal or abnormal substances. (B)</p> Signup and view all the answers

What is the term for the accumulation of proteins in proximal tubule cells of the kidney in patients with nephrotic syndrome?

<p>Eosinophilic droplets (B)</p> Signup and view all the answers

Flashcards are hidden until you start studying

More Like This

Cell Injury II
15 questions

Cell Injury II

HonorableTsavorite avatar
HonorableTsavorite
Pathology: Cell Injury and Its Causes
18 questions
ANA 404: Cellular Reactions to Injury II
10 questions
Cell Injury and Impacts
47 questions

Cell Injury and Impacts

SophisticatedLitotes842 avatar
SophisticatedLitotes842
Use Quizgecko on...
Browser
Browser