12 Questions
What is the primary mechanism by which glutamate is made?
Conversion of glutamine by glutaminase
What ion plays a crucial role in causing exocytosis of vesicular glutamate?
Calcium (Ca2+)
Which ion is NMDA receptor permeable to?
Calcium and Sodium
Which receptor does Ketamine primarily act on?
NMDA receptor
What is a pharmacologically distinct modulatory site from the glutamate site on the NMDA receptor?
Glycine site
What effect do glycine transport blockers have on NMDA receptors?
Facilitate functioning without excitotoxic effects
Which neurotransmitter is responsible for anxiety control by facilitating GABAA receptor function?
Acetylcholine
What is the primary mechanism of action of benzodiazepines in relieving anxiety?
Facilitating GABAA receptor function
What is the underlying cause of Huntington's disease?
Loss of cholinergic neurons in basal ganglia
How do barbiturates exert their anticonvulsant effects?
Extending GABAA receptor channel opening
Which neurotransmitter is primarily involved in movement control in the basal ganglia?
Acetylcholine
What neurotransmitter interaction in the brain is related to addiction to nicotine?
Acetylcholine with dopamine
Learn about the process of glutamate transmission, including the conversion of glutamine, vesicular transport, exocytosis, receptor binding, and reuptake mechanisms. Understand how glutamate functions as an excitatory amino acid in producing fast excitatory EPSPs.
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