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Glutamate Transmission Process Overview

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Questions and Answers

What is the primary mechanism by which glutamate is made?

Conversion of GABA by GABA decarboxylase

Conversion of aspartate by aspartate synthase

Conversion of glutamine by glutaminase (correct)

Conversion of glycine by glycine transporter

What ion plays a crucial role in causing exocytosis of vesicular glutamate?

Potassium (K+)

Calcium (Ca2+) (correct)

Sodium (Na+)

Chloride (Cl-)

Which ion is NMDA receptor permeable to?

Magnesium and Zinc

Calcium and Sodium (correct)

Potassium and Chloride

Iron and Copper

Which receptor does Ketamine primarily act on?

NMDA receptor (C) Signup and view all the answers

What is a pharmacologically distinct modulatory site from the glutamate site on the NMDA receptor?

Glycine site (C) Signup and view all the answers

What effect do glycine transport blockers have on NMDA receptors?

Facilitate functioning without excitotoxic effects (A) Signup and view all the answers

Which neurotransmitter is responsible for anxiety control by facilitating GABAA receptor function?

Acetylcholine (A) Signup and view all the answers

What is the primary mechanism of action of benzodiazepines in relieving anxiety?

Facilitating GABAA receptor function (C) Signup and view all the answers

What is the underlying cause of Huntington's disease?

Loss of cholinergic neurons in basal ganglia (D) Signup and view all the answers

How do barbiturates exert their anticonvulsant effects?

Extending GABAA receptor channel opening (C) Signup and view all the answers

Which neurotransmitter is primarily involved in movement control in the basal ganglia?

Acetylcholine (B) Signup and view all the answers

What neurotransmitter interaction in the brain is related to addiction to nicotine?

Acetylcholine with dopamine (B) Signup and view all the answers