Glutamate Transmission Process Overview

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Questions and Answers

What is the primary mechanism by which glutamate is made?

  • Conversion of GABA by GABA decarboxylase
  • Conversion of aspartate by aspartate synthase
  • Conversion of glutamine by glutaminase (correct)
  • Conversion of glycine by glycine transporter

What ion plays a crucial role in causing exocytosis of vesicular glutamate?

  • Potassium (K+)
  • Calcium (Ca2+) (correct)
  • Sodium (Na+)
  • Chloride (Cl-)

Which ion is NMDA receptor permeable to?

  • Magnesium and Zinc
  • Calcium and Sodium (correct)
  • Potassium and Chloride
  • Iron and Copper

Which receptor does Ketamine primarily act on?

<p>NMDA receptor (C)</p> Signup and view all the answers

What is a pharmacologically distinct modulatory site from the glutamate site on the NMDA receptor?

<p>Glycine site (C)</p> Signup and view all the answers

What effect do glycine transport blockers have on NMDA receptors?

<p>Facilitate functioning without excitotoxic effects (A)</p> Signup and view all the answers

Which neurotransmitter is responsible for anxiety control by facilitating GABAA receptor function?

<p>Acetylcholine (A)</p> Signup and view all the answers

What is the primary mechanism of action of benzodiazepines in relieving anxiety?

<p>Facilitating GABAA receptor function (C)</p> Signup and view all the answers

What is the underlying cause of Huntington's disease?

<p>Loss of cholinergic neurons in basal ganglia (D)</p> Signup and view all the answers

How do barbiturates exert their anticonvulsant effects?

<p>Extending GABAA receptor channel opening (C)</p> Signup and view all the answers

Which neurotransmitter is primarily involved in movement control in the basal ganglia?

<p>Acetylcholine (B)</p> Signup and view all the answers

What neurotransmitter interaction in the brain is related to addiction to nicotine?

<p>Acetylcholine with dopamine (B)</p> Signup and view all the answers

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