Podcast
Questions and Answers
Which neurotransmitter is characterized as a major inhibitory transmitter in the CNS?
Which neurotransmitter is characterized as a major inhibitory transmitter in the CNS?
- Glutamate
- Kainic acid
- Gamma-aminobutyric acid (GABA) (correct)
- Aspartate
Which type of glutamate receptor subtype is coupled to G proteins and leads to long-term changes in neuronal functions/neuronal plasticity?
Which type of glutamate receptor subtype is coupled to G proteins and leads to long-term changes in neuronal functions/neuronal plasticity?
- NMDA receptors (correct)
- AMPA receptors
- Kainic acid receptors
- Delta receptors
What is the effect of GABAA receptor activation?
What is the effect of GABAA receptor activation?
- Sodium ion efflux
- Chloride ion influx and subsequent hyperpolarization (correct)
- Neuronal excitation
- Potassium ion influx
Which amino acid is characterized as an excitatory amino acid found in very high concentrations in the brain?
Which amino acid is characterized as an excitatory amino acid found in very high concentrations in the brain?
What is the major role of glutamate in the CNS?
What is the major role of glutamate in the CNS?
Which type of glutamate receptor subtype is characterized as an ionotropic receptor?
Which type of glutamate receptor subtype is characterized as an ionotropic receptor?
What type of receptor is the GABAA receptor?
What type of receptor is the GABAA receptor?
Which ion enters the neuron upon activation of the GABAA receptor?
Which ion enters the neuron upon activation of the GABAA receptor?
What are the two major excitatory amino acids found in very high concentrations in the brain?
What are the two major excitatory amino acids found in very high concentrations in the brain?
Which type of glutamate receptor subtype is named after its most selective agonist that activates it?
Which type of glutamate receptor subtype is named after its most selective agonist that activates it?
What type of receptor is the NMDA receptor?
What type of receptor is the NMDA receptor?
What happens when NMDA receptors are activated due to high/sustained stimulation?
What happens when NMDA receptors are activated due to high/sustained stimulation?
What is the primary mechanism of action of GABAB receptor activation?
What is the primary mechanism of action of GABAB receptor activation?
Which class of adjuvant analgesics acts by inhibiting norepinephrine and serotonin reuptake?
Which class of adjuvant analgesics acts by inhibiting norepinephrine and serotonin reuptake?
What is the major site of action for gabapentin in providing analgesia?
What is the major site of action for gabapentin in providing analgesia?
What is the primary action of NMDA receptor antagonists in the context of pain management?
What is the primary action of NMDA receptor antagonists in the context of pain management?
Which class of drugs is primarily used to counter the effects of peripheral sensitization?
Which class of drugs is primarily used to counter the effects of peripheral sensitization?
What is the mechanism of action underlying the use of capsaicin as an analgesic?
What is the mechanism of action underlying the use of capsaicin as an analgesic?
What is the purported effect of rubefacients upon application?
What is the purported effect of rubefacients upon application?
What is the major site of action for TCA-associated analgesia?
What is the major site of action for TCA-associated analgesia?
Which neurotransmitter is primarily affected by the mechanism of action of GABAB receptor activation?
Which neurotransmitter is primarily affected by the mechanism of action of GABAB receptor activation?
What is the primary pharmacokinetic characteristic of gabapentin?
What is the primary pharmacokinetic characteristic of gabapentin?
What is the mechanism of action underlying the use of menthol as an analgesic?
What is the mechanism of action underlying the use of menthol as an analgesic?
What is the primary site of action for NMDA receptor antagonists in pain management?
What is the primary site of action for NMDA receptor antagonists in pain management?
