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Questions and Answers
What is a haplotype?
A haplotype is a set of polymorphisms that are grouped tightly together on a single chromosome and tend to be inherited together through many generations.
How can microsatellites be used as genetic markers?
Microsatellites can be used as genetic markers to track haplotypes.
What is linkage analysis?
Linkage analysis is a method used to associate haplotypes with traits or map genes to characters.
What is a gene?
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What is a haplogroup?
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What is the purpose of crossing over in meiosis I?
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What is the relationship between haplotypes and crossing over?
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What is a haploid genotype?
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What are SNPs?
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What is the function of DNA/genetic signature?
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What is the concept of genetic recombination and gene mapping?
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How did Thomas Hunt Morgan contribute to the understanding of genetic recombination and gene mapping?
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What is a chromosomal linkage map?
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How can haplotypes be used to identify the gene responsible for a shared trait in related individuals?
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What are tandem repeat non-coding DNA sequences?
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What are the three types of tandem repeats?
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What are the characteristics of satellite DNA?
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What are the characteristics of minisatellite DNA?
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What are the characteristics of microsatellite DNA?
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What is the importance of genetic markers in identifying haplotypes?
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What is consanguinity and how can it increase the risk for hereditary disorders?
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How can molecular 'bar coding' of haplotypes using microsatellites be used to track hereditary disease in consanguineous lineages?
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What are the principles behind the coefficient of relationship and coefficient of inbreeding?
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What is the Hardy-Weinberg principle/equation and how is it used to calculate allele and genotype frequencies?
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How can the Hardy-Weinberg principle/equation be used to calculate inheritance risk in a population in Hardy-Weinberg equilibrium?
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What is the definition of consanguineous marriage?
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What are the associated risks of consanguineous marriage?
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What percentage of children have consanguineous parents?
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What is the probability of having a child without a constitutional congenital defect in consanguineous marriages?
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What are the advantages of consanguineous marriage?
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What is the probability that Nasreen's sibling will also be homozygous for the deafness-associated haplotype?
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What is the coefficient of relationship (COR) between full siblings?
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What is the coefficient of inbreeding (COI) for a person whose parents are half-siblings?
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How can allele frequency be calculated?
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What is the allele frequency if 10% of 100 people are homozygous for allele R1 (20 copies) and 20% are heterozygous for allele R1 (20 copies)?
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What is the Hardy-Weinberg principle?
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What is the Hardy-Weinberg equation?
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Under what conditions does a population remain in Hardy-Weinberg equilibrium?
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How is the frequency of heterozygosity (carrier frequency) determined in clinical genetics?
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What proportion of the population has allele R1 if its frequency is 40%?
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