Gas Exchange: Oxygen and Carbon Dioxide

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Questions and Answers

According to Henry's Law, what is the relationship between the quantity of a gas that dissolves in a liquid and the partial pressure of that gas?

  • The quantity of gas that dissolves is independent of the partial pressure of the gas.
  • The quantity of gas that dissolves is inversely proportional to the partial pressure of the gas.
  • The quantity of gas that dissolves is directly proportional to the partial pressure of the gas. (correct)
  • The quantity of gas that dissolves is equal to the square root of the partial pressure of the gas.

What does Dalton's Law state regarding the total pressure of a mixture of gases?

  • The total pressure is the average of the pressures of individual gases.
  • The total pressure is the sum of the pressures of individual gases. (correct)
  • The total pressure is the pressure of the most abundant gas in the mixture.
  • The total pressure is the product of the pressures of individual gases.

How does the pressure of a gas change as the volume of its container changes, according to Boyle's Law?

  • The pressure changes inversely with the volume. (correct)
  • The pressure changes proportionally with the volume.
  • The pressure changes logarithmically with the volume.
  • The pressure remains constant regardless of the volume change.

Which of the following best describes the movement of gases concerning concentration gradients?

<p>Gases move from areas of high concentration to low concentration due to diffusion. (B)</p> Signup and view all the answers

Where does carbon dioxide (CO2) enter the alveoli?

<p>At the alveolar-capillary interface. (D)</p> Signup and view all the answers

In what forms is oxygen primarily transported in the blood?

<p>Dissolved in plasma or bound to hemoglobin inside red blood cells (RBCs). (B)</p> Signup and view all the answers

After diffusing out of cells, what happens to carbon dioxide (CO2)?

<p>It is transported dissolved, bound to hemoglobin, or as HCO3-. (C)</p> Signup and view all the answers

What is the primary role of cellular respiration in relation to carbon dioxide (CO2)?

<p>To determine metabolic CO2 production. (D)</p> Signup and view all the answers

Which of the following processes is directly controlled to regulate ventilation?

<p>Gas exchange in lungs and tissues. (A)</p> Signup and view all the answers

What are the three highlighted controls related to gas exchange and transport?

<p>Gas exchange in lungs and tissues, gas transport in blood, and regulation of ventilation. (B)</p> Signup and view all the answers

How does oxygen enter the blood from the alveoli?

<p>At the alveolar-capillary interface. (B)</p> Signup and view all the answers

What is the role of hemoglobin in oxygen transport?

<p>It binds oxygen within red blood cells for efficient transport. (C)</p> Signup and view all the answers

Which of the following processes leads to the production of metabolic carbon dioxide (CO2)?

<p>Cellular respiration. (D)</p> Signup and view all the answers

What happens to oxygen after it diffuses into cells?

<p>It is used in cellular respiration. (A)</p> Signup and view all the answers

In systemic circulation, how is oxygen primarily transported from the lungs to the body tissues?

<p>Bound to hemoglobin inside red blood cells. (A)</p> Signup and view all the answers

Which of the following accurately describes the path of carbon dioxide (CO2) from body tissues back to the lungs?

<p>CO2 is transported dissolved in plasma, bound to hemoglobin, or as HCO3-. (B)</p> Signup and view all the answers

How does pulmonary circulation differ from systemic circulation in terms of oxygen and carbon dioxide transport?

<p>Pulmonary circulation carries deoxygenated blood to the lungs to get oxygenated, while systemic circulation distributes oxygenated blood to the body. (B)</p> Signup and view all the answers

What role does HCO3- (bicarbonate) play in the transport of carbon dioxide (CO2)?

<p>It serves as one of the forms in which CO2 is transported in the blood. (C)</p> Signup and view all the answers

How do changes in volume affect the pressure of a gas within a container, according to Boyle's Law, assuming the amount of gas and temperature remain constant?

<p>Decreasing the volume increases the pressure. (D)</p> Signup and view all the answers

Pulmonary and systemic circulations perform distinct roles. Which statement accurately contrasts these?

<p>Pulmonary circulation delivers deoxygenated blood to the lungs, where carbon dioxide is exchanged for oxygen; systemic circulation then delivers this oxygenated blood to body tissues. (C)</p> Signup and view all the answers

What is the definition of partial pressure in the context of a gas mixture?

<p>The pressure exerted by a single component gas in the mixture. (B)</p> Signup and view all the answers

Given that atmospheric air pressure is 760 mmHg and air is typically 20% oxygen, how is the partial pressure of oxygen ($pO_2$) calculated?

<p>By multiplying 760 mmHg by 0.2 (20% oxygen). (A)</p> Signup and view all the answers

Which of the following factors directly influences the rate of gas diffusion between the alveoli and the blood?

<p>The thickness of the barrier between the alveoli and the blood. (C)</p> Signup and view all the answers

How does alveolar ventilation primarily affect alveolar gas exchange?

<p>By supplying fresh air to the alveoli and removing carbon dioxide. (C)</p> Signup and view all the answers

How does the composition of inspired air affect alveolar gas exchange?

<p>It alters the partial pressures of gases available for exchange. (B)</p> Signup and view all the answers

What role does the rate and depth of breathing play in alveolar gas exchange?

<p>It determines the amount of fresh air that reaches the alveoli per minute. (B)</p> Signup and view all the answers

How does increased airway resistance impact alveolar ventilation?

<p>It decreases the amount of air reaching the alveoli. (B)</p> Signup and view all the answers

Why is adequate perfusion of the alveoli essential for efficient gas exchange?

<p>It ensures that blood is available to pick up oxygen and release carbon dioxide. (D)</p> Signup and view all the answers

How does lung compliance affect alveolar ventilation?

<p>By influencing how easily the lungs can expand during inspiration. (B)</p> Signup and view all the answers

What is the effect of increased fluid in the alveoli on gas exchange?

<p>It reduces the surface area available for gas exchange. (B)</p> Signup and view all the answers

Considering that air is approximately 20% oxygen and the total air pressure is 760 mmHg, what is the partial pressure of oxygen ($pO_2$)?

<p>152 mmHg (B)</p> Signup and view all the answers

How does an increase in the surface area of the alveoli typically affect gas exchange?

<p>It enhances the rate of gas diffusion. (A)</p> Signup and view all the answers

Which condition would most directly impair oxygen from reaching the alveoli?

<p>An obstruction in the airway. (B)</p> Signup and view all the answers

What is the significance of maintaining a short diffusion distance between the alveoli and the blood?

<p>It allows for more efficient gas exchange. (C)</p> Signup and view all the answers

Which of the following scenarios would lead to a decrease in the partial pressure of oxygen ($pO_2$) in the alveoli?

<p>Decreased rate and depth of breathing. (C)</p> Signup and view all the answers

If a person is breathing air with a lower than normal oxygen concentration, how will this affect their alveolar gas exchange?

<p>It will reduce the concentration gradient for oxygen diffusion. (B)</p> Signup and view all the answers

How does pulmonary edema (fluid accumulation in the lungs) affect gas exchange in the alveoli?

<p>By increasing the diffusion distance for gases. (D)</p> Signup and view all the answers

What is the effect of decreased lung compliance on alveolar ventilation?

<p>It causes less air to enter the lungs with each breath. (D)</p> Signup and view all the answers

Which of the following changes would most directly improve the amount of oxygen reaching the alveoli?

<p>Breathing air with a higher concentration of oxygen. (B)</p> Signup and view all the answers

Which factor, if increased, would most likely decrease the rate of gas diffusion between the alveoli and the blood?

<p>Thickness of the alveolar-capillary membrane. (B)</p> Signup and view all the answers

How does a greater pressure difference between the two sides of a membrane affect the flow rate of gases across it?

<p>It increases the flow rate linearly. (D)</p> Signup and view all the answers

What effect does a larger surface area for gas exchange have on the amount of gas that can pass across a membrane over a given time?

<p>It enables a greater amount of gas to pass across. (C)</p> Signup and view all the answers

How does the thickness of a membrane affect the rate of gas diffusion across it?

<p>A thinner membrane results in a higher rate of diffusion. (C)</p> Signup and view all the answers

What impact does a gas's solubility in the membrane have on its rate of diffusion?

<p>Greater solubility results in a higher rate of diffusion. (C)</p> Signup and view all the answers

According to the diffusion equation, $Vgas = (A \times D \times (P1 - P2)) / T$, how would doubling the membrane thickness ($T$) affect the volume of gas ($Vgas$) diffusing through the membrane, assuming all other factors remain constant?

<p>It would halve the volume of gas diffusing. (B)</p> Signup and view all the answers

How does emphysema, characterized by the destruction of alveoli, affect gas exchange in the lungs?

<p>Reduces the surface area available for gas exchange. (A)</p> Signup and view all the answers

What is the primary effect of fibrotic lung disease on alveolar gas exchange?

<p>Thickened alveolar membrane, reducing gas exchange efficiency. (A)</p> Signup and view all the answers

How does pulmonary edema affect gas exchange in the alveoli?

<p>Increases the diffusion distance due to fluid accumulation. (B)</p> Signup and view all the answers

What is the primary mechanism by which asthma affects alveolar ventilation?

<p>Increased airway resistance due to bronchoconstriction. (C)</p> Signup and view all the answers

In the context of gas diffusion across the alveolar membrane, which of the following changes would most significantly increase the rate of oxygen transfer from the alveoli into the blood?

<p>Increasing the surface area of the alveolar membrane. (B)</p> Signup and view all the answers

A patient has a condition that reduces the surface area of their alveoli by 50%. Assuming all other factors remain constant, what would be the expected change in the rate of gas diffusion across the alveolar membrane?

<p>The rate of diffusion would be reduced by 50%. (C)</p> Signup and view all the answers

A patient with a respiratory disease has an increased alveolar membrane thickness which is double the normal thickness. How is the rate of gas diffusion affected, if other parameters remain constant?

<p>Halved. (C)</p> Signup and view all the answers

How does an increase in the partial pressure difference of oxygen between the alveolar air and the blood affect the net movement of oxygen?

<p>Increases the net movement of oxygen from the alveoli to the blood. (D)</p> Signup and view all the answers

If the solubility of carbon dioxide in the alveolar membrane were to decrease, what effect would this have on the rate of carbon dioxide diffusion?

<p>Decrease in the rate of diffusion. (B)</p> Signup and view all the answers

A patient presents with pulmonary fibrosis, leading to a significant increase in the thickness of the alveolar membrane. How will this condition affect the volume of gas diffusing across the membrane, assuming all other factors remain constant?

<p>The volume of gas diffusing will decrease due to the increased thickness. (B)</p> Signup and view all the answers

How does the loss of alveolar surface area in conditions like emphysema affect the relationship between diffusion and surface area?

<p>It decreases the diffusion rate due to less area available for gas exchange. (C)</p> Signup and view all the answers

Given the diffusion equation $Vgas = (A \times D \times (P1 - P2)) / T$, what adjustments might the body make if 'A' (surface area) is significantly reduced due to a disease but the body needs to maintain a stable $Vgas$?

<p>Increase 'D' (gas solubility) and decrease 'T' (membrane thickness). (A)</p> Signup and view all the answers

A patient's alveolar membrane permeability decreases due to scar tissue formation. How would the body compensate to maintain normal gas exchange, assuming other factors remain constant?

<p>Increase the ventilation rate to enhance the concentration gradient. (B)</p> Signup and view all the answers

A patient with severe asthma has significantly narrowed airways, which reduces alveolar ventilation. How will this condition primarily affect the partial pressures of oxygen ($pO_2$) and carbon dioxide ($pCO_2$) in the alveoli?

<p>Decrease $pO_2$ and increase $pCO_2$. (E)</p> Signup and view all the answers

In a scenario where a person is at high altitude with lower atmospheric pressure, what is the immediate physiological response that helps maintain adequate alveolar ventilation?

<p>Increased rate and depth of breathing. (A)</p> Signup and view all the answers

How does the partial pressure of oxygen ($pO_2$) change as blood flows through the arteries in systemic circulation?

<p>It gradually decreases as oxygen is exchanged with tissues. (D)</p> Signup and view all the answers

Which statement accurately describes the change in partial pressure of carbon dioxide ($pCO_2$) in systemic veins as they approach the lungs?

<p>It increases as carbon dioxide is released from tissue respiration. (B)</p> Signup and view all the answers

Where is the concentration of $pCO_2$ the highest?

<p>Venules that empty into veins (D)</p> Signup and view all the answers

What primarily drives the movement of oxygen and carbon dioxide across cell membranes in the body?

<p>Partial pressure gradients (B)</p> Signup and view all the answers

How does the partial pressure of oxygen ($pO_2$) in pulmonary veins compare to that in systemic arteries, and why?

<p>Higher, because pulmonary veins carry oxygenated blood from the lungs to the heart for systemic circulation. (D)</p> Signup and view all the answers

What is the primary factor determining the rate of gas exchange in the tissues?

<p>The partial pressure differences of gases. (B)</p> Signup and view all the answers

In metabolically active tissues, how are the partial pressures of oxygen ($pO_2$) and carbon dioxide ($pCO_2$) typically altered compared to less active tissues?

<p>$pO_2$ is lower and $pCO_2$ is higher due to increased oxygen consumption and increased carbon dioxide production. (C)</p> Signup and view all the answers

How does the $pO_2$ change in the pulmonary vein before reaching the heart, and why?

<p>Decreases slightly because the lungs and heart are metabolically active. (A)</p> Signup and view all the answers

How do partial pressures of oxygen and carbon dioxide in the alveoli influence gas exchange with pulmonary capillaries?

<p>High $pO_2$ in alveoli and low $pCO_2$ in capillaries promote oxygen diffusion into the blood and carbon dioxide into the alveoli. (B)</p> Signup and view all the answers

What would happen to the $pO_2$ and $pCO_2$ levels in the blood if ventilation were increased without a corresponding change in metabolic rate?

<p>$pO_2$ would increase, and $pCO_2$ would decrease. (C)</p> Signup and view all the answers

Which of the following best describes how oxygen and carbon dioxide move between the alveoli and the blood?

<p>Oxygen moves into the blood and carbon dioxide moves into the alveoli, both down their concentration gradients. (B)</p> Signup and view all the answers

How does gas exchange in the tissues depend on $pO_2$?

<p>Gases move down the $pO_2$ gradient, with oxygen moving into the tissues. (B)</p> Signup and view all the answers

Which partial pressures are responsible for gas movement?

<p>The partial pressures of both oxygen ($pO_2$) and carbon dioxide ($pCO_2$). (C)</p> Signup and view all the answers

During gas exchange in the lungs, how do the partial pressures of oxygen and carbon dioxide change as blood flows from the pulmonary artery to the pulmonary vein?

<p>Oxygen partial pressure increases, and carbon dioxide partial pressure decreases. (B)</p> Signup and view all the answers

How does tissue respiration influence the partial pressure of carbon dioxide ($pCO_2$) in the veins?

<p>Increases $pCO_2$ due to carbon dioxide production (B)</p> Signup and view all the answers

A patient has a condition that impairs their ability to eliminate carbon dioxide from the lungs efficiently. What changes would be expected in the partial pressures of gases in their arterial blood?

<p>Decreased $pO_2$ and increased $pCO_2$. (D)</p> Signup and view all the answers

How does the concentration gradient affect gas movement?

<p>Gases move down the concentration gradient. (A)</p> Signup and view all the answers

Which of the following happens more in metabolically active tissues than pulmonary tissues?

<p>Consuming more oxygen. (D)</p> Signup and view all the answers

How are oxygen levels in arteries other than pulmonary?

<p>High levels but gradually decrease. (A)</p> Signup and view all the answers

How are carbon dioxide levels in veins other than pulmonary?

<p>Increases as they get closer to the heart and the lungs. (A)</p> Signup and view all the answers

Flashcards

Henry's Law

The quantity of a gas that will dissolve in a liquid is proportional to the partial pressure of the gas.

Dalton's Law

The total pressure of a mixture of gases is the sum of the pressures of the individual gases.

Boyle's Law

If the volume of a container of gas changes, the pressure of the gas will change in an inverse manner: P1V1 = P2V2

Gas Movement

Gases move from an area of high concentration to an area of low concentration.

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CO2 in Alveoli

CO2 enters alveoli at the alveolar-capillary interface.

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Oxygen to Blood

Oxygen enters the blood at the alveolar-capillary interface.

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CO2 Transport

CO2 is transported dissolved, bound to hemoglobin, or as HCO3-

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Oxygen Transport

Oxygen is transported in blood dissolved in plasma or bound to hemoglobin inside RBCs.

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CO2 Diffusion

CO2 diffuses out of cells.

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Oxygen Intake

Oxygen diffuses into cells.

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Controls

Includes gas exchange in lungs and tissues, gas transport in blood, and regulation of ventilation.

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Partial Pressure

Pressure exerted by an individual gas in a mixture of gases; sum of these equals total pressure.

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pO2 calculation in air

pO2 in air = 0.2 x 760 mmHg = 152 mmHg. Where 0.2 is the percentage of O2 in the air and 760 mmHg is the air pressure

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O2 reaching alveoli

The process where oxygen reaches the alveoli.

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Composition of Inspired Air

The amount and type of gases inhaled.

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Alveolar Ventilation

The process of air moving in and out of the alveoli.

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Airway Resistance

Resistance in the respiratory passageways.

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Lung Compliance

The ease with which the lungs can expand.

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Gas Diffusion

Spreading of gases between the alveoli and the blood.

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Adequate Perfusion of Alveoli

Amount of alveolar blood flow.

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Surface area

The total area available for gas exchange.

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Diffusion Distance

The thickness of the barrier between alveoli and blood.

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Barrier Thickness

Thickness of the membrane separating air and blood.

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Amount of Fluid

Fluid volume in the alveoli.

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Pressure difference and flow rate

The difference in pressure between two points, affects flow rate; a greater difference results in a faster flow rate.

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Surface area and gas exchange

A larger surface area allows greater amount of gas to pass across a membrane over a given time.

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Membrane thickness

A thinner membrane allows for a higher rate of diffusion.

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Gas solubility

Greater solubility of gas in membrane results in a greater rate of diffusion.

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Vgas

Volume of gas diffusing through membrane

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Factors affecting diffusion

Diffusion is directly proportional to surface area and barrier permeability, and inversely proportional to the square of distance.

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Emphysema

Destruction of alveoli means less surface area for gas exchange.

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Pulmonary Edema

Fluid in interstitial space increases diffusion distance.

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Asthma

Increased airway resistance decreases alveolar ventilation.

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Fibrotic Lung Disease

Thickened alveolar membrane slows gas exchange.

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Gas Movement Drivers

Pressure gradients of O2 and CO2 drive gas movement.

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Arterial pO2 Changes

In arteries, pO2 is high and gradually decreases as gas exchange occurs in metabolically active tissues.

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Venous pCO2 Changes

In veins, pCO2 increases as they approach the heart and lungs due to CO2 release from tissue respiration. The highest concentration of pCO2 is in the venules.

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Pulmonary Vein pO2

In the pulmonary vein, pO2 is high and slightly decreases before reaching the heart and lungs.

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Gas Exchange Gradient

Gas exchange depends on pO2 differences in tissues. Gases move down their pressure gradients: O2 in, CO2 out.

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Gas Concentration Gradient

Gases move down their concentration gradients from high conc to low conc

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Study Notes

  • Partial pressures of Oâ‚‚ and COâ‚‚ are responsible for the movement of gases
  • Gases move down concentration gradient
  • In arteries, pOâ‚‚ is high and gradually decreases as gas exchange occurs in metabolically active tissues
    • This is other than pulmonary
  • Gas exchange in tissues depends on pOâ‚‚ differences
  • Gases move down partial pressure gradient, Oâ‚‚ in and COâ‚‚ out
  • In veins, pCOâ‚‚ increases as they get closer to the heart and lungs due to COâ‚‚ release in tissue respiration
    • The highest concentration of pCOâ‚‚ is in venules that empty into veins
    • This is other than pulmonary
  • In the pulmonary vein, pOâ‚‚ is high and slightly decreases before reaching the heart, lungs are metabolically active

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