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Factor Xa Inhibitors Overview

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@CompliantJasper4970

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Questions and Answers

What is the primary mechanism of action of Factor Xa inhibitors like Rivaroxaban and Apixaban?

Inhibits thrombin

Inhibits platelets

Inhibits factor Xa (correct)

Increases clotting factor production

What are the indications for using Factor Xa inhibitors?

Management of acute coronary syndrome

Prevention of stroke in hemodialysis patients

Only for patients with heart failure

Treatment of DVT and PE, and prevention of clots in atrial fibrillation (correct)

What significant risk is associated with the abrupt discontinuation of Factor Xa inhibitors?

Increased risk of liver toxicity

Increased risk of gastrointestinal bleeding

Increased risk of thromboembolic events (correct)

Increased risk of kidney damage

What is another term for Factor Xa inhibitors, such as Rivaroxaban and Apixaban?

<p>Direct oral anticoagulants (DOAC)</p> Signup and view all the answers

Which agent is used to reverse the effects of Factor Xa inhibitors?

<p>Factor Xa</p> Signup and view all the answers

Study Notes

Factor Xa Inhibitors

Drug Class: Factor Xa inhibitors
Drugs: Rivaroxaban (Xarelto), Apixaban (Eliquis)
Mechanism of Action: Inhibits Factor Xa, a key enzyme in the coagulation cascade, directly preventing the formation of thrombin and blood clots.
Indications:
- Treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE)
- Prevention of clots in patients with atrial fibrillation
Black Box Warning: Abrupt discontinuation of Factor Xa inhibitors carries an increased risk of thromboembolic events (blood clots).
Also Known As: Direct Oral Anticoagulants (DOACs)
Reversal: Factor Xa inhibitors can be reversed with specific factor Xa reversal agents.

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Description

This quiz covers the key aspects of Factor Xa inhibitors, including their mechanism of action, indications for use, and important safety warnings. It highlights drugs like Rivaroxaban and Apixaban as part of the Direct Oral Anticoagulants class. Test your knowledge about these medications and their clinical applications.