18 Questions
Mutations are heritable changes in the genome that do not result in genotypic variation.
False
Successful mutations are those that do not impart any selective advantage to the organism.
False
Directed change is the only way mutations can arise according to Luria and Delbrück.
False
The frequency of DNA replication errors in wild type E. coli is approximately $1 imes 10^{-3}$ per genome per generation.
True
Bacterial genetics is highly predictable and follows a linear pattern similar to a small town.
False
Horizontal gene transfer only occurs between bacteria and their host organisms.
False
During base substitution, transition occurs when a purine switches to a pyrimidine.
True
In frameshift mutations, the wild type reading frame remains the same even if one or more bases are inserted or deleted.
False
The presence of stop codons like UAA, UAG, and UGA in DNA sequences can lead to nonsense mutations.
True
A synonymous mutation results in changing the amino acid sequence of a protein.
False
Genetic rearrangements involve changes in the sequence of nucleotides within a gene.
True
Pathogens always cause disease by growing and colonizing in the host organism.
False
In evolution, new genes can only arise de novo without any relation to existing genes.
False
Horizontal gene transfer is an intrinsic mechanism for the emergence of new genes in bacteria.
False
Gene duplication can lead to the emergence of new functions in proteins due to mutations in the extra copy.
True
Point mutations have a high likelihood of directly leading to the emergence of new functions.
False
Gene gain and gene loss are part of the process of genome reduction in bacteria.
True
Mutation during non-functionality model suggests that new genes can emerge when an existing gene is duplicated during non-functionality.
True
Learn about how bacterial genomes evolve through gene acquisition, mutation, and genome reduction. Discover how new genes and functions arise in infectious agents, affecting their survival, reproduction, and competition with the resident microbiome.
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