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Questions and Answers
Which year was etomidate introduced?
Which year was etomidate introduced?
- 1972 (correct)
- 1992
- 1982
- 1962
What is the chemical name of etomidate?
What is the chemical name of etomidate?
- Esr2 alpha methyl benzene imidazole five carboxylic
- Esr1 beta methyl benzene imidazole five carboxylic
- Esr1 alpha methyl benzene imidazole five carboxylic (correct)
- Esr2 beta methyl benzene imidazole five carboxylic
Is etomidate water-soluble?
Is etomidate water-soluble?
- Yes (correct)
- No
What is the pH of the propylene glycol solution?
What is the pH of the propylene glycol solution?
What is the osmolarity of the propylene glycol solution?
What is the osmolarity of the propylene glycol solution?
What is the stability of etomidate in water?
What is the stability of etomidate in water?
What is the formulation of etomidate in a clear eco solution?
What is the formulation of etomidate in a clear eco solution?
What percentage of propylene glycol is present in the solution?
What percentage of propylene glycol is present in the solution?
Is etomidate a racemic mixture?
Is etomidate a racemic mixture?
What are the adverse effects of the propylene glycol solution?
What are the adverse effects of the propylene glycol solution?
Which of the following is true about the elimination half-life of etomidate?
Which of the following is true about the elimination half-life of etomidate?
What is the main mechanism of metabolism for etomidate?
What is the main mechanism of metabolism for etomidate?
How does etomidate affect the central nervous system?
How does etomidate affect the central nervous system?
What effect does etomidate have on the cardiovascular system?
What effect does etomidate have on the cardiovascular system?
How does etomidate affect the respiratory system?
How does etomidate affect the respiratory system?
What effect does etomidate have on the hepatorenal system?
What effect does etomidate have on the hepatorenal system?
What effect does etomidate have on the immune system?
What effect does etomidate have on the immune system?
What adverse effect is associated with etomidate?
What adverse effect is associated with etomidate?
What is the recommended use of etomidate during labor and obstetric delivery?
What is the recommended use of etomidate during labor and obstetric delivery?
What is the most common adverse effect of etomidate during recovery?
What is the most common adverse effect of etomidate during recovery?
Etomidate is used for the induction of general anesthesia in adults and children because it leads to rapid loss of consciousness within one and brain circulation time.
Etomidate is used for the induction of general anesthesia in adults and children because it leads to rapid loss of consciousness within one and brain circulation time.
Which statement about etomidate is correct?
Which statement about etomidate is correct?
What is the contraindication for the use of etomidate?
What is the contraindication for the use of etomidate?
What is the mechanism of action of etomidate?
What is the mechanism of action of etomidate?
What is the IV dose of etomidate for obese patients?
What is the IV dose of etomidate for obese patients?
What is the volume of distribution of etomidate?
What is the volume of distribution of etomidate?
Etomidate is contraindicated for the maintenance of anesthesia and long-term infusions for sedation in intensive care due to its effects on steroid metabolism.
Etomidate is contraindicated for the maintenance of anesthesia and long-term infusions for sedation in intensive care due to its effects on steroid metabolism.
Etomidate has a reduced adrenal cortical suppression due to its modified imidazole ring.
Etomidate has a reduced adrenal cortical suppression due to its modified imidazole ring.
Etomidate does not trigger malignant hyperthermia.
Etomidate does not trigger malignant hyperthermia.
Etomidate is administered in a large ring to reduce the incidence of pain on injection.
Etomidate is administered in a large ring to reduce the incidence of pain on injection.
Study Notes
Introduction to Etomidate
- Etomidate was introduced in the year 1983.
- The chemical name of etomidate is R-(+)-ethyl-1-(1-phenylethyl)-1H-imidazole-5-carboxylate.
Physical Properties and Formulation
- Etomidate is not water-soluble.
- The propylene glycol solution has a pH of 6.0.
- The osmolarity of the propylene glycol solution is 4650 osm/L.
- Etomidate is formulated in a clear eco solution with 35% propylene glycol.
Pharmacology
- Etomidate is a racemic mixture.
- The stability of etomidate in water is poor.
- The main mechanism of metabolism for etomidate is hepatic metabolism.
- Etomidate affects the central nervous system by inducing rapid loss of consciousness.
- Etomidate reduces cerebral blood flow and oxygen consumption.
Cardiovascular and Respiratory Systems
- Etomidate has minimal effects on the cardiovascular system.
- Etomidate can cause apnea, especially in patients with pre-existing respiratory disease.
Hepatorenal and Immune Systems
- Etomidate has minimal effects on the hepatorenal system.
- Etomidate suppresses the immune system, particularly the adrenal cortex.
Adverse Effects and Contraindications
- Adverse effects of the propylene glycol solution include pain, thrombophlebitis, and hypertension.
- Etomidate is contraindicated for the maintenance of anesthesia and long-term infusions for sedation in intensive care.
- The recommended use of etomidate during labor and obstetric delivery is contraindicated.
- The most common adverse effect of etomidate during recovery is nausea and vomiting.
Clinical Use and Dosing
- Etomidate is used for the induction of general anesthesia in adults and children.
- The IV dose of etomidate for obese patients is 0.3 mg/kg.
- The volume of distribution of etomidate is 1.5-5.5 L/kg.
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Description
Test your knowledge on the chemistry and properties of the anesthetic drug etomidate in this informative quiz. Learn about its chemical structure, solubility, and formulation.
