Questions and Answers
What class does Etomidate belong to?
What is the mechanism of action (MOA) of Etomidate?
Ultra short acting hypnotic that causes GABA binding, producing anesthesia.
What are the indications for using Etomidate?
The induction dose of Etomidate is ______ mg/kg IV/IO bolus.
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Which of the following is a contraindication for Etomidate?
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What adverse effect is linked to the use of Etomidate?
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What is the onset time for Etomidate?
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Etomidate has a duration of ______ minutes.
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It is safe to use Etomidate in patients with adrenal issues.
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Study Notes
Etomidate Overview
- Non-barbiturate hypnotic known as Amidate, used for rapid anesthesia.
Mechanism of Action
- Functions as an ultra short-acting hypnotic within the benzylmidazole class.
- Promotes GABA binding leading to increased influx of chloride ions, reducing neuronal activity.
- Causes a temporary decrease in cerebral blood flow, which lowers oxygen consumption.
Indications for Use
- Primarily indicated for procedural sedation.
- Suitable for induction during Rapid Sequence Intubation (RSI).
Dosing Information
- Adult and Pediatric Induction: Administer 0.2 - 0.6 mg/kg via IV/IO bolus.
- Maintenance infusion recommended at 10-20 mcg/kg/min.
Contraindications
- Not recommended for prolonged use.
- Contraindicated in patients with adrenal insufficiency.
- Avoid in cases of sepsis.
- Exercise caution in pediatric patients under the age of 10.
Adverse Effects
- Can lead to adrenal suppression by inhibiting 11B-hydroxylase, affecting steroid production.
- Possible suppression of steroid synthesis for 6 to 24 hours post-administration.
- Other effects include muscle tremors and risk of apnea.
Pharmacokinetics
- Rapid onset of action: Approximately 1 minute.
- Duration of effect ranges from 2 to 10 minutes.
Special Considerations
- High mortality rates are associated with usage in patients with adrenal insufficiency.
- Adrenal suppression may result in delayed cardiovascular instability, necessitating careful monitoring.
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Description
Test your knowledge on Etomidate (Amidate) with these flashcards covering its class, mechanism of action, and clinical indications. Ideal for medical students and healthcare professionals looking to enhance their understanding of this hypnotic agent.
