Etomidate and Cerebral Parameters

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Questions and Answers

What is the percentage decrease in cerebral metabolic rate of oxygen (CMRO2) observed with etomidate at doses of 0.2 to 0.3 mg/kg?

50%
34%
45% (correct)
60%

What must be done to maintain etomidate's effect on intracranial pressure (ICP)?

Increase the patient's blood pressure.
Administer lower doses of etomidate.
Use high infusion rates of etomidate. (correct)
Combine etomidate with another anesthetic.

What change occurs in the cerebral blood flow (CBF) after administration of etomidate?

Increases by 34%
Decreases by 34% (correct)
Remains unchanged
Increases by 50%

What effect does etomidate have on auditory evoked potentials?

<p>Increased latency and decreased amplitude (A)</p> Signup and view all the answers

Which of the following is still under debate concerning etomidate?

<p>Its neuroprotective qualities (A)</p> Signup and view all the answers

Flashcards

Etomidate's effect on CBF

Etomidate reduces cerebral blood flow (CBF) by about 34% at doses of 0.2 to 0.3 mg/kg.

Etomidate's effect on CMRO2

Etomidate decreases cerebral metabolic rate of oxygen (CMRO2) by about 45% at doses of 0.2 to 0.3 mg/kg.

Etomidate's effect on CPP

Etomidate maintains or increases cerebral perfusion pressure (CPP).

Etomidate's acute ICP effect

Etomidate, when causing EEG burst suppression, acutely lowers intracranial pressure (ICP) by 50% in patients with pre-existing high ICP.

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Maintaining etomidate's ICP effect

High infusion rates (60 mcg/kg/min) are needed to maintain etomidate's effects on intracranial pressure (ICP).

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Study Notes

Etomidate Effects on Cerebral Parameters

Etomidate (0.2-0.3 mg/kg) reduces cerebral blood flow (CBF) by 34% and cerebral metabolic rate of oxygen (CMRO2) by 45%, without affecting mean arterial pressure (MAP).
Cerebral perfusion pressure (CPP) is maintained or increased. This leads to a beneficial net increase in cerebral oxygen supply relative to demand.
Etomidate, at sufficient doses to cause EEG burst suppression, acutely decreases intracranial pressure (ICP) by 50% in patients with pre-existing elevated ICP, returning ICP to near-normal levels.

Maintaining ICP Reduction

The reduction in ICP is sustained in the period immediately following intubation.
Maintaining this effect requires high infusion rates (60 mcg/kg/min).
The neuroprotective qualities of etomidate are still under discussion.
There's a dose-dependent increase in the latency and a decrease in amplitude of auditory evoked potentials.

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Description

Explore the effects of Etomidate on cerebral blood flow, metabolic rates, and intracranial pressure. This quiz covers its neuroprotective effects and the implications of its dosage on cerebral function. Test your knowledge on how Etomidate affects cerebral parameters after intubation.