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What is the percentage decrease in cerebral metabolic rate of oxygen (CMRO2) observed with etomidate at doses of 0.2 to 0.3 mg/kg?
What is the percentage decrease in cerebral metabolic rate of oxygen (CMRO2) observed with etomidate at doses of 0.2 to 0.3 mg/kg?
What must be done to maintain etomidate's effect on intracranial pressure (ICP)?
What must be done to maintain etomidate's effect on intracranial pressure (ICP)?
What change occurs in the cerebral blood flow (CBF) after administration of etomidate?
What change occurs in the cerebral blood flow (CBF) after administration of etomidate?
What effect does etomidate have on auditory evoked potentials?
What effect does etomidate have on auditory evoked potentials?
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Which of the following is still under debate concerning etomidate?
Which of the following is still under debate concerning etomidate?
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Study Notes
Etomidate Effects on Cerebral Parameters
- Etomidate (0.2-0.3 mg/kg) reduces cerebral blood flow (CBF) by 34% and cerebral metabolic rate of oxygen (CMRO2) by 45%, without affecting mean arterial pressure (MAP).
- Cerebral perfusion pressure (CPP) is maintained or increased. This leads to a beneficial net increase in cerebral oxygen supply relative to demand.
- Etomidate, at sufficient doses to cause EEG burst suppression, acutely decreases intracranial pressure (ICP) by 50% in patients with pre-existing elevated ICP, returning ICP to near-normal levels.
Maintaining ICP Reduction
- The reduction in ICP is sustained in the period immediately following intubation.
- Maintaining this effect requires high infusion rates (60 mcg/kg/min).
- The neuroprotective qualities of etomidate are still under discussion.
- There's a dose-dependent increase in the latency and a decrease in amplitude of auditory evoked potentials.
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Description
Explore the effects of Etomidate on cerebral blood flow, metabolic rates, and intracranial pressure. This quiz covers its neuroprotective effects and the implications of its dosage on cerebral function. Test your knowledge on how Etomidate affects cerebral parameters after intubation.
