Podcast
Questions and Answers
What percentage of alcohol is absorbed in the stomach?
What percentage of alcohol is absorbed in the stomach?
- 40%
- 30%
- 20% (correct)
- 10%
Which organ is responsible for metabolizing about 90% of the alcohol in the body?
Which organ is responsible for metabolizing about 90% of the alcohol in the body?
- Liver (correct)
- Pancreas
- Lungs
- Kidneys
What is the primary toxic compound yielded from alcohol metabolism by colon bacterial ADH?
What is the primary toxic compound yielded from alcohol metabolism by colon bacterial ADH?
- Ethanol
- Formaldehyde
- Methanol
- Acetaldehyde (correct)
Which system is important for breaking down large amounts of alcohol?
Which system is important for breaking down large amounts of alcohol?
What is the main compound that is excreted into the urine after alcohol metabolism?
What is the main compound that is excreted into the urine after alcohol metabolism?
What represents 1 unit for clinical purposes in terms of pure alcohol content?
What represents 1 unit for clinical purposes in terms of pure alcohol content?
What is the primary target of peroxidation caused by free radical release in the liver?
What is the primary target of peroxidation caused by free radical release in the liver?
What contributes to the transient hyperglycemia observed after ethanol consumption with a meal?
What contributes to the transient hyperglycemia observed after ethanol consumption with a meal?
What is the consequence of an accumulation of acetaldehyde in the liver after ethanol consumption?
What is the consequence of an accumulation of acetaldehyde in the liver after ethanol consumption?
What contributes to the formation of acetaldehyde adducts in chronic ethanol consumption?
What contributes to the formation of acetaldehyde adducts in chronic ethanol consumption?
What is the consequence of the increased NADH/NAD+ ratio on FA metabolism?
What is the consequence of the increased NADH/NAD+ ratio on FA metabolism?
How does ethanol-induced hyperlipidemia occur?
How does ethanol-induced hyperlipidemia occur?
What is the result of ethanol metabolism on ketone body production?
What is the result of ethanol metabolism on ketone body production?
How does ethanol affect gluconeogenesis in fasting individuals?
How does ethanol affect gluconeogenesis in fasting individuals?
What happens to OAA levels in the TCA cycle due to ethanol metabolism?
What happens to OAA levels in the TCA cycle due to ethanol metabolism?
How does an increase in lactate affect blood glucose levels during fasting with ethanol consumption?
How does an increase in lactate affect blood glucose levels during fasting with ethanol consumption?
Which enzyme family is primarily responsible for the metabolism of ethanol in the liver?
Which enzyme family is primarily responsible for the metabolism of ethanol in the liver?
Which enzyme has a higher affinity for acetaldehyde and is very specific in its action?
Which enzyme has a higher affinity for acetaldehyde and is very specific in its action?
What is the preferred antidote for overdoses of methanol or ethylene glycol?
What is the preferred antidote for overdoses of methanol or ethylene glycol?
Which enzyme is responsible for generating toxic acetaldehyde, particularly in the liver?
Which enzyme is responsible for generating toxic acetaldehyde, particularly in the liver?
Individuals with an allelic variant of which enzyme have a greatly decreased capacity for acetaldehyde metabolism?
Individuals with an allelic variant of which enzyme have a greatly decreased capacity for acetaldehyde metabolism?
Chronic consumption of ethanol can lead to an increase in which enzyme levels by 5-10 fold?
Chronic consumption of ethanol can lead to an increase in which enzyme levels by 5-10 fold?
How does disulfiram deter the consumption of alcohol in a chronic alcoholic patient?
How does disulfiram deter the consumption of alcohol in a chronic alcoholic patient?
What effect does disulfiram have on the metabolism of ethanol in the body?
What effect does disulfiram have on the metabolism of ethanol in the body?
What role does the inhibition of ketogenesis play in the mechanism of disulfiram?
What role does the inhibition of ketogenesis play in the mechanism of disulfiram?
How does disulfiram affect the balance between NAD and NADH?
How does disulfiram affect the balance between NAD and NADH?
What is the consequence of activating FAO in the presence of disulfiram?
What is the consequence of activating FAO in the presence of disulfiram?
Which metabolic process is most affected by disulfiram in a chronic alcoholic?
Which metabolic process is most affected by disulfiram in a chronic alcoholic?
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