Epstein-Barr virus ʹ Ye Olde Epstein Bar
20 Questions
1 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the primary mode of transmission for Epstein-Barr virus?

  • Through contaminated food and water
  • Through skin contact
  • Through mouth secretions (correct)
  • Through airborne transmission

    • What is the characteristic symptom of infectious mononucleosis?

  • Splenomegaly
  • Tender lymphadenopathy in posterior cervical
  • Pharyngitis
  • All of the above (correct)

    • Which cells are primarily affected by Epstein-Barr virus?

  • T cells
  • Neutrophils
  • B cells (correct)
  • Macrophages

    • What is the role of cytotoxic T cells in response to Epstein-Barr virus infection?

    <p>They directly kill infected B cells</p> Signup and view all the answers

    What is the typical age range for infectious mononucleosis to occur?

    <p>Adolescents and young adults</p> Signup and view all the answers

    What is the name of the receptor that Epstein-Barr virus binds to infect B cells?

    <p>CD21</p> Signup and view all the answers

    What is the characteristic rash associated with Epstein-Barr virus infection?

    <p>Maculopapular rash</p> Signup and view all the answers

    What is the increased risk factor for certain types of cancer in individuals with weakened immune systems?

    <p>All of the above</p> Signup and view all the answers

    What is the term for the proliferation of T cells in response to Epstein-Barr virus infection?

    <p>Reactive lymphocytosis</p> Signup and view all the answers

    What is the characteristic laboratory finding in infectious mononucleosis?

    <p>Presence of heterophil antibodies</p> Signup and view all the answers

    What is the form of DNA that the Epstein-Barr virus consists of?

    <p>Double-stranded DNA</p> Signup and view all the answers

    How is the Epstein-Barr virus primarily spread?

    <p>Through mouth secretions when people kiss</p> Signup and view all the answers

    What is the term for the swollen lymph nodes in the neck associated with infectious mononucleosis?

    <p>Posterior cervical lymphadenopathy</p> Signup and view all the answers

    What is the type of immune cell that is primarily affected by the Epstein-Barr virus?

    <p>B cells</p> Signup and view all the answers

    What is the term for the abnormal increase in the number of T cells in response to EBV infection?

    <p>Lymphocytosis</p> Signup and view all the answers

    What is the name of the receptor on B cells that the Epstein-Barr virus binds to in order to infect them?

    <p>CD21</p> Signup and view all the answers

    What is the characteristic rash associated with infectious mononucleosis and ampicillin treatment?

    <p>Maculopapular rash</p> Signup and view all the answers

    What is the increased risk factor for certain types of cancer in individuals with weakened immune systems?

    <p>All of the above</p> Signup and view all the answers

    What is the term for the spleen becoming enlarged in response to Epstein-Barr virus infection?

    <p>Splenomegaly</p> Signup and view all the answers

    What is the difference in presentation between infectious mononucleosis and strep pharyngitis?

    <p>Age of onset</p> Signup and view all the answers

    Study Notes

    Epstein-Barr Virus (EBV)

    • EBV is a double-stranded DNA virus that causes infectious mononucleosis.
    • It is spread through mouth secretions, also known as the "kissing disease".

    Infectious Mononucleosis

    • Symptoms include fever, tender lymphadenopathy in the posterior cervical region, and reactive lymphocytosis (also known as downy cells).
    • The virus targets B lymphocytes, and T cells proliferate, causing splenomegaly.

    Immune Response

    • Cytotoxic T cells (TH8) are involved in the immune response.
    • T cells bind to CD21, a receptor for complement component CD3, to infect B cells.

    Clinical Features

    • Pharyngitis is a common symptom, with tonsillar exudates present.
    • Mono occurs in late teens and adulthood, whereas strep pharyngitis is more often seen in children.
    • A maculopapular rash can develop with penicillin treatment, especially with amoxicillin and ampicillin.

    Cancer Risk

    • EBV is an increased risk factor for three cancers:
      • B cell lymphoma (in weakened immune systems)
      • Burkitt lymphoma (in African populations)
      • Nasopharyngeal carcinoma (in Asian populations)

    Other Complications

    • Oral hairy leukoplakia can occur in HIV patients, but it is not a precancerous lesion.
    • Monospot IgG test is used to diagnose EBV during acute infection, which secretes heterophile sheep antibodies that agglutinate.

    Precautions

    • Contact sports should be avoided due to the risk of splenic rupture.

    Epstein-Barr Virus (EBV)

    • EBV is a double-stranded DNA virus that causes infectious mononucleosis.
    • It is spread through mouth secretions, also known as the "kissing disease".

    Infectious Mononucleosis

    • Symptoms include fever, tender lymphadenopathy in the posterior cervical region, and reactive lymphocytosis (also known as downy cells).
    • The virus targets B lymphocytes, and T cells proliferate, causing splenomegaly.

    Immune Response

    • Cytotoxic T cells (TH8) are involved in the immune response.
    • T cells bind to CD21, a receptor for complement component CD3, to infect B cells.

    Clinical Features

    • Pharyngitis is a common symptom, with tonsillar exudates present.
    • Mono occurs in late teens and adulthood, whereas strep pharyngitis is more often seen in children.
    • A maculopapular rash can develop with penicillin treatment, especially with amoxicillin and ampicillin.

    Cancer Risk

    • EBV is an increased risk factor for three cancers:
      • B cell lymphoma (in weakened immune systems)
      • Burkitt lymphoma (in African populations)
      • Nasopharyngeal carcinoma (in Asian populations)

    Other Complications

    • Oral hairy leukoplakia can occur in HIV patients, but it is not a precancerous lesion.
    • Monospot IgG test is used to diagnose EBV during acute infection, which secretes heterophile sheep antibodies that agglutinate.

    Precautions

    • Contact sports should be avoided due to the risk of splenic rupture.

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    More Like This

    Use Quizgecko on...
    Browser
    Open
    Browser
    Browser