Epigenetic Changes in Aging and Cancer

Qual é o papel do ATRX nas células?

Mantém a estabilidade do genoma

O que é resultado da perda de ATRX?

Instabilidade genômica e resposta a danos no DNA alterada

Qual é o papel do telomerase na idade celular?

Não tem efeito na idade celular

Qual é o resultado da expressão do telomerase em células com idade celular?

Não tem efeito na idade celular Signup and view all the answers

Qual é o papel da resposta a danos no DNA no processo de envelhecimento?

Induz o envelhecimento Signup and view all the answers

Qual é a relação entre a idade celular e o telomerase?

A idade celular é independente do telomerase Signup and view all the answers

Qual é o papel da epigenética no envelhecimento?

Induz o envelhecimento Signup and view all the answers

Qual é o objetivo das terapias baseadas na epigenética no tratamento do câncer?

Inibir o crescimento tumoral Signup and view all the answers

Qual é o papel das senolíticas no tratamento do câncer?

Inibir o crescimento tumoral Signup and view all the answers

Qual é a relação entre a dieta e o envelhecimento?

A dieta previne o envelhecimento Signup and view all the answers

What is the outcome of nonmutagenic double-strand repair in the epigenetic landscape?

Erosion of the epigenetic landscape Signup and view all the answers

What is the target of oxidative damage in promoter CpG Islands?

Complexes containing DNA methyltransferases, SIRT1, and polycomb members Signup and view all the answers

What is the consequence of the loss of epigenetic information in mammalian cells?

Aging due to malfunctioning cells Signup and view all the answers

What is the role of polycomb chromatin modifiers in regulating cellular senescence?

Through histone methylation-dependent pathways Signup and view all the answers

What is the outcome of processive DNA synthesis at the sites of DNA replication and repair?

Localized decompaction of constitutive heterochromatin Signup and view all the answers

What is the effect of BRAF mutations on the aged and aberrantly methylated intestinal epithelium?

Rapid neoplastic transformation Signup and view all the answers

What is the relationship between the DNA damage response and transcription stress?

The DNA damage response is enhanced by transcription stress Signup and view all the answers

What is the role of SIRT1 in the regulation of epigenetic information?

It targets complexes containing DNA methyltransferases to promoter CpG Islands Signup and view all the answers

What is the outcome of the regulation of cellular senescence by polycomb chromatin modifiers?

Cellular senescence Signup and view all the answers

What is the relationship between oxidative damage and DNA methyltransferases in promoter CpG Islands?

Oxidative damage targets complexes containing DNA methyltransferases Signup and view all the answers