Endothelial Cell Injury and Monocyte Emigration Quiz

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Questions and Answers

What is a risk factor that can damage the endothelium?

  • Exercise
  • Smoking (correct)
  • Low LDL levels
  • Vitamin C

What happens to monocytes after they attach to the endothelium?

  • They migrate into the intimal layer (correct)
  • They release antithrombotic cytokines
  • They transform into smooth muscle cells
  • They leave the endothelium

What is formed when macrophages consume oxidized LDLs?

  • Inflammatory cytokines
  • Smooth muscle cells
  • Foam cells (correct)
  • Platelet aggregates

What is the result of smooth muscle proliferation?

<p>The vessel lumen becomes smaller (B)</p> Signup and view all the answers

What happens to LDLs when they penetrate intact endothelium?

<p>They quickly oxidize into proinflammatory lipids (A)</p> Signup and view all the answers

What is the result of oxidized LDLs on monocyte migration?

<p>Oxidized LDLs attract more monocytes (B)</p> Signup and view all the answers

What is the primary reason for monocyte emigration into the intimal layer?

<p>As a direct result of endothelial cell injury (B)</p> Signup and view all the answers

What is the consequence of endothelial injury on its function?

<p>Loss of ability to produce antithrombotic and vasodilating cytokines (A)</p> Signup and view all the answers

What is the role of hemodynamic factors in atherosclerosis?

<p>They promote the formation of atherosclerotic lesions in areas of turbulent flow (B)</p> Signup and view all the answers

What is the consequence of oxidized LDLs on the vessel lumen?

<p>It decreases in size due to smooth muscle proliferation (D)</p> Signup and view all the answers

What is the role of platelets in atherosclerosis?

<p>They aggregate and adhere to the site of injury, leading to smooth muscle proliferation (B)</p> Signup and view all the answers

What is the outcome of the positive feedback situation in atherosclerosis?

<p>Increased endothelial injury and advanced atherogenesis (A)</p> Signup and view all the answers

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