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Endothelial Cell Functions Quiz
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Endothelial Cell Functions Quiz

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Questions and Answers

Why is the physiology of the endothelium particularly important to pharmacists?

  • It does not interact with vasoactive substances
  • It has no impact on drug absorption
  • It regulates the movement of small and large molecules (correct)
  • It functions as an inert tube lining
  • What is the role of L-NAME in the mechanism of endothelial-dependent vascular smooth muscle cell (VSMC) relaxation?

  • Inhibits NO release (correct)
  • Increases responsiveness to contractile agents
  • Stimulates the release of NO
  • Enhances vasorelaxation
  • How does the presence of an endothelial layer affect the impact of phenylephrine and nor-adrenaline on arterial tone?

  • Completely inhibits their action
  • Enhances their effect on arterial tone
  • Has no impact on arterial tone
  • Reduces their effect on arterial tone (correct)
  • What is the primary function of nitrovasodilators in clinical use?

    <p>To increase cGMP levels intracellularly</p> Signup and view all the answers

    Which statement regarding NO release from endothelial cells is true?

    <p>NO is released constitutively and can be stimulated by agonists</p> Signup and view all the answers

    How do organic nitrates primarily impact intracellular levels?

    <p>Increase cGMP levels</p> Signup and view all the answers

    Which of the following is NOT a function of the endothelial cells?

    <p>Oxygen transport</p> Signup and view all the answers

    What is the name of the molecule discovered by Salvador Moncada in 1976 that regulates vascular tone?

    <p>Prostacyclin</p> Signup and view all the answers

    What is the name of the molecule initially known as EDRF (endothelium-derived relaxing factor) that was discovered by Furchgott and Zawadzki in 1980?

    <p>Nitric oxide</p> Signup and view all the answers

    Which of the following phenotypes is associated with endothelial cell dysfunction?

    <p>All of the above</p> Signup and view all the answers

    According to the image, what do the green and red fluorescent colors represent in a blood vessel?

    <p>Green: Smooth muscle cells (circumferential and longitudinal), Red: Adventitia</p> Signup and view all the answers

    Which of the following statements about the endothelium is correct?

    <p>All of the above.</p> Signup and view all the answers

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