Transcapillary Exchange

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Which substance has the highest permeability across the capillary membrane?

Urea

Glucose

Water (correct)

NaCl

Which substance has the lowest permeability across the capillary membrane?

Myoglobin

Albumin (correct)

Hemoglobin

Inulin

Which type of molecules can diffuse directly through the endothelial cell membrane?

Macromolecules

Non-lipid soluble substances

Water-soluble substances

Lipid-soluble substances (correct)

How do water-soluble and non-lipid soluble substances move across the capillary membrane?

Through pores Signup and view all the answers

What is the ultrafiltrate of plasma called?

Interstitial fluid Signup and view all the answers

What do lymphatic capillaries do?

Drain excess fluid from the interstitial compartment Signup and view all the answers

What is the formula for fluid filtration across the capillaries according to Starling's relationship?

Jv,c = (PC - PIF) - (πc - πIF) Signup and view all the answers

What does the osmotic reflection coefficient (σ) represent?

The probability that a molecule will cross the barrier Signup and view all the answers

What does a σ value of 0 indicate?

The membrane is freely permeable to the solute Signup and view all the answers

What does a σ value of 1 indicate?

The molecule is impermeable to the solute Signup and view all the answers

Which of the following factors influence transcapillary exchange of fluid?

Permeability, hydrostatic pressure, and oncotic pressure Signup and view all the answers

What is the net filtration pressure at the arterial end of a capillary?

Hydrostatic pressure plus oncotic pressure Signup and view all the answers

What is the net filtration pressure at the venous end of a capillary?

Oncotic pressure minus hydrostatic pressure Signup and view all the answers

How does net filtration pressure affect the direction of fluid movement across the capillary?

It determines the direction of fluid movement Signup and view all the answers

How is transcapillary macromolecular exchange related to molecular size and capillary permeability?

Smaller molecules have higher permeability Signup and view all the answers

How is capillary structure related to the osmotic reflection coefficient?

Capillary structure determines the osmotic reflection coefficient Signup and view all the answers

What factors govern transcapillary exchange according to the Starling Relationship?

Permeability, hydrostatic pressure, and oncotic pressure Signup and view all the answers

How can the Starling Relation be applied to different physiological perturbations?

By adjusting both hydrostatic and oncotic pressures Signup and view all the answers

How can endogenous compound release alter capillary permeability?

By increasing capillary permeability Signup and view all the answers

Why does normal net capillary filtration not result in edema?

Because lymph flow prevents fluid accumulation Signup and view all the answers