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16 Questions

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Pharm IBS and IBD medications

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Questions and Answers

What is the mechanism of action of sulfasalazine?

Blocks TNF-alpha receptors

Suppresses purine synthesis

Reduces inflammation by releasing 5-aminosalicylic acid (5-ASA) in the gut (correct)

Inhibits dihydrofolate reductase

Which adverse effect is commonly associated with sulfasalazine?

Photosensitivity (correct)

QT prolongation

Pulmonary fibrosis

Nephrotoxicity

What is the primary indication for budesonide in IBD?

Refractory Crohn's disease

Severe ulcerative colitis

Mild to moderate Crohn's disease (correct)

Maintenance of remission in ulcerative colitis

Which black-box warning is associated with azathioprine?

Increased risk of malignancy Signup and view all the answers

What monitoring is required for azathioprine use?

Liver function tests and CBC Signup and view all the answers

Which enzyme deficiency increases the risk of toxicity from azathioprine?

TPMT (thiopurine methyltransferase) Signup and view all the answers

What is the mechanism of action of mercaptopurine?

Inhibits purine synthesis Signup and view all the answers

Which side effect is most commonly associated with cyclosporine?

Gingival hyperplasia Signup and view all the answers

Which condition is infliximab primarily used to treat?

Moderate to severe ulcerative colitis Signup and view all the answers

What is the mechanism of action of infliximab?

Blocks TNF-alpha to reduce inflammation Signup and view all the answers

What is a black-box warning for infliximab?

Risk of serious infections and malignancy Signup and view all the answers

Which adverse effect is most commonly associated with methotrexate?

Pulmonary fibrosis Signup and view all the answers

What is the mechanism of action of methotrexate?

Inhibits dihydrofolate reductase, suppressing DNA synthesis Signup and view all the answers

Which medication is most effective for maintenance of remission in ulcerative colitis?

Mesalamine Signup and view all the answers

Which IBD medication is associated with nephrotoxicity and requires renal monitoring?

Cyclosporine Signup and view all the answers

What is the main role of budesonide in IBD treatment?

Short-term induction of remission Signup and view all the answers

Study Notes

Drug Mechanisms & Side Effects

Sulfasalazine: Reduces inflammation by releasing 5-aminosalicylic acid (5-ASA) in the gut. A common side effect is photosensitivity.
Budesonide: Primarily indicated for mild to moderate Crohn's disease.
Azathioprine: A medication with a black-box warning for increased risk of malignancy. Monitoring of liver function tests (LFTs) and complete blood count (CBC) is essential.
Azathioprine Toxicity: Thiopurnine methyltransferase (TPMT) enzyme deficiency increases the risk of toxicity.
Mercaptopurine: Inhibits purine synthesis.
Cyclosporine: A common side effect is gingival hyperplasia.
Infliximab: Primarily used to treat moderate to severe ulcerative colitis. Its mechanism is the blocking of TNF-alpha to reduce inflammation. A black-box warning involves serious infections and malignancy.
Methotrexate: A common side effect is pulmonary fibrosis, its mechanism involves inhibiting dihydrofolate reductase which suppresses DNA synthesis.

IBD Medications

Mesalamine: Effective for maintenance of remission in ulcerative colitis.
Budesonide: Significant role in short-term induction of remission in Inflammatory Bowel Disease (IBD) treatment.
Cyclosporine: Has a potential for nephrotoxicity, requiring renal monitoring.

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Description

Test your knowledge on various drug mechanisms and their potential side effects. This quiz covers medications like Sulfasalazine, Azathioprine, and Infliximab, among others, as well as their specific therapeutic indications and toxicities. Enhance your understanding of pharmacology through this insightful quiz.