Podcast
Questions and Answers
What is the mechanism of action of tetracyclines?
What is the mechanism of action of tetracyclines?
- Causing misreading of messenger RNA (mRNA)
- Inhibiting DNA replication in bacterial cells
- Preventing binding of amino-acyl transfer RNA (tRNA) to the ribosome (correct)
- Preventing protein synthesis by inhibiting ribosomal initiation complex formation
Which statement about tigecycline is true?
Which statement about tigecycline is true?
- It is ineffective against Gram-positive bacteria
- It retains activity against many bacteria susceptible to other tetracyclines (correct)
- It has limited activity against chlamediae and rickettsiae
- It works by inhibiting the formation of ribosomal initiation complex
What is the main limitation that resistance has imposed on tetracyclines?
What is the main limitation that resistance has imposed on tetracyclines?
- Prevention of binding amino-acyl transfer RNA (tRNA) to the ribosome
- Limited value against many Gram-positive and Gram-negative bacteria (correct)
- Decreased ability to cause misreading of mRNA
- Reduced effectiveness against chlamydia and rickettsia
Which antibiotic acts by interfering with the action of bacterial dihydrofolate reductase?
Which antibiotic acts by interfering with the action of bacterial dihydrofolate reductase?
What is the enzyme that catalyzes the last step of bacterial folic acid synthesis?
What is the enzyme that catalyzes the last step of bacterial folic acid synthesis?
Which bacterial species are usually susceptible to tetracyclines despite resistance seen in others?
Which bacterial species are usually susceptible to tetracyclines despite resistance seen in others?
Which antibiotic is a structural analog of para aminobenzoic acid (PABA) and competes with it to bind to dihydropterote synthetase?
Which antibiotic is a structural analog of para aminobenzoic acid (PABA) and competes with it to bind to dihydropterote synthetase?
What is a notable side effect associated with aminoglycosides?
What is a notable side effect associated with aminoglycosides?
Which antibiotics exhibit potent antipseudomonal activity but have limited usefulness due to toxicity?
Which antibiotics exhibit potent antipseudomonal activity but have limited usefulness due to toxicity?
What type of effect arises between sulphonamides and trimethoprim when used in combination?
What type of effect arises between sulphonamides and trimethoprim when used in combination?
Which antibiotic has a role in the treatment of infections caused by multidrug-resistant organisms?
Which antibiotic has a role in the treatment of infections caused by multidrug-resistant organisms?
How do macrolide antibiotics act?
How do macrolide antibiotics act?
What is the mechanism of action of chloramphenicol?
What is the mechanism of action of chloramphenicol?
Which antibiotic has been limited in use due to the occurrence of rare but fatal side effects like aplastic anemia?
Which antibiotic has been limited in use due to the occurrence of rare but fatal side effects like aplastic anemia?
What is the primary target of fusidic acid in bacterial cells?
What is the primary target of fusidic acid in bacterial cells?
Which organism is NOT sensitive to macrolide antibiotics?
Which organism is NOT sensitive to macrolide antibiotics?
Resistance to antibiotics can arise from alterations in:
Resistance to antibiotics can arise from alterations in:
