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Diuretics and Natriuretics in Nephrotic Syndrome Management

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Diuretics and Natriuretics in Nephrotic Syndrome Management

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Questions and Answers

What is the mechanism of action of thiazide diuretics?

Inhibition of carbonic anhydrase in the proximal convoluted tubule

Inhibition of aldosterone receptors in the distal nephron

Inhibition of the Na/Cl transporter in the distal convoluted tubule (correct)

Inhibition of the Na/K/2Cl transporter in the ascending limb of Henle’s loop

Which of the following is NOT an adverse effect associated with loop diuretics?

Ototoxicity

Hyperuricemia

Hypocalcemia

Hypercalcemia (correct)

What is a common indication for thiazide diuretics?

Anion overdose

Nephrogenic diabetes insipidus (correct)

Peripheral edema

Acute hypercalcemia

Which of the following is NOT a pharmacological effect of thiazide diuretics?

Marked increase in NaCl excretion Signup and view all the answers

Which condition is NOT listed as an indication for loop diuretics?

Anion overdose Signup and view all the answers

Which thiazide diuretic can be administered parenterally?

Chlorothiazide Signup and view all the answers

Which of the following best describes the role of a diuretic in nephrotic syndrome?

Increasing urine volume and reducing excess fluid in the body Signup and view all the answers

In which scenario would diuretics NOT be recommended for a patient with nephrotic syndrome?

Severe kidney damage or dehydration Signup and view all the answers

What effect can diuretic use have on patients with reduced plasma volume?

Impair GFR and lead to orthostatic hypotension Signup and view all the answers

Why might diuretics not be beneficial for all cases of nephrotic syndrome?

They can worsen kidney function in patients with severe damage Signup and view all the answers

What is the primary function of a natriuretic agent?

Increase in renal sodium excretion Signup and view all the answers