Diuretics and Natriuretics in Nephrotic Syndrome Management
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Questions and Answers

What is the mechanism of action of thiazide diuretics?

  • Inhibition of carbonic anhydrase in the proximal convoluted tubule
  • Inhibition of aldosterone receptors in the distal nephron
  • Inhibition of the Na/Cl transporter in the distal convoluted tubule (correct)
  • Inhibition of the Na/K/2Cl transporter in the ascending limb of Henle’s loop
  • Which of the following is NOT an adverse effect associated with loop diuretics?

  • Ototoxicity
  • Hyperuricemia
  • Hypocalcemia
  • Hypercalcemia (correct)
  • What is a common indication for thiazide diuretics?

  • Anion overdose
  • Nephrogenic diabetes insipidus (correct)
  • Peripheral edema
  • Acute hypercalcemia
  • Which of the following is NOT a pharmacological effect of thiazide diuretics?

    <p>Marked increase in NaCl excretion</p> Signup and view all the answers

    Which condition is NOT listed as an indication for loop diuretics?

    <p>Anion overdose</p> Signup and view all the answers

    Which thiazide diuretic can be administered parenterally?

    <p>Chlorothiazide</p> Signup and view all the answers

    Which of the following best describes the role of a diuretic in nephrotic syndrome?

    <p>Increasing urine volume and reducing excess fluid in the body</p> Signup and view all the answers

    In which scenario would diuretics NOT be recommended for a patient with nephrotic syndrome?

    <p>Severe kidney damage or dehydration</p> Signup and view all the answers

    What effect can diuretic use have on patients with reduced plasma volume?

    <p>Impair GFR and lead to orthostatic hypotension</p> Signup and view all the answers

    Why might diuretics not be beneficial for all cases of nephrotic syndrome?

    <p>They can worsen kidney function in patients with severe damage</p> Signup and view all the answers

    What is the primary function of a natriuretic agent?

    <p>Increase in renal sodium excretion</p> Signup and view all the answers

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