Diuretics and Natriuretics in Nephrotic Syndrome Management
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Questions and Answers

What is the mechanism of action of thiazide diuretics?

  • Inhibition of carbonic anhydrase in the proximal convoluted tubule
  • Inhibition of aldosterone receptors in the distal nephron
  • Inhibition of the Na/Cl transporter in the distal convoluted tubule (correct)
  • Inhibition of the Na/K/2Cl transporter in the ascending limb of Henle’s loop

Which of the following is NOT an adverse effect associated with loop diuretics?

  • Ototoxicity
  • Hyperuricemia
  • Hypocalcemia
  • Hypercalcemia (correct)

What is a common indication for thiazide diuretics?

  • Anion overdose
  • Nephrogenic diabetes insipidus (correct)
  • Peripheral edema
  • Acute hypercalcemia

Which of the following is NOT a pharmacological effect of thiazide diuretics?

<p>Marked increase in NaCl excretion (D)</p> Signup and view all the answers

Which condition is NOT listed as an indication for loop diuretics?

<p>Anion overdose (D)</p> Signup and view all the answers

Which thiazide diuretic can be administered parenterally?

<p>Chlorothiazide (D)</p> Signup and view all the answers

Which of the following best describes the role of a diuretic in nephrotic syndrome?

<p>Increasing urine volume and reducing excess fluid in the body (D)</p> Signup and view all the answers

In which scenario would diuretics NOT be recommended for a patient with nephrotic syndrome?

<p>Severe kidney damage or dehydration (B)</p> Signup and view all the answers

What effect can diuretic use have on patients with reduced plasma volume?

<p>Impair GFR and lead to orthostatic hypotension (B)</p> Signup and view all the answers

Why might diuretics not be beneficial for all cases of nephrotic syndrome?

<p>They can worsen kidney function in patients with severe damage (B)</p> Signup and view all the answers

What is the primary function of a natriuretic agent?

<p>Increase in renal sodium excretion (A)</p> Signup and view all the answers

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