Development of the Nervous System

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Questions and Answers

Which germ layer is responsible for the development of the central and peripheral nervous system?

  • Neural crest
  • Ectoderm (correct)
  • Mesoderm
  • Endoderm

What structure induces the ectoderm to form the neural plate during embryonic development?

  • Neural tube
  • Notochord (correct)
  • Ectoderm
  • Mesoderm

What is the primary role of the notochord in vertebrate embryos?

  • Forms the brain
  • Produces neural crest cells
  • Promotes the formation of limbs
  • Guides development of the nervous system and vertebrae (correct)

During neurulation, what happens to the cranial and caudal ends of the neural tube?

<p>They remain open as neuropores (C)</p> Signup and view all the answers

What condition is characterized by a small brain and cranium, often due to neural tube defects?

<p>Microcephaly (C)</p> Signup and view all the answers

Which structure forms as the edges of the neural plate rise during the process of neurulation?

<p>Neural fold (B)</p> Signup and view all the answers

What does the neural canal eventually become in the developed nervous system?

<p>Ventricular system and central canal (D)</p> Signup and view all the answers

Which of the following best describes exencephaly?

<p>Brain develops outside the skull (B)</p> Signup and view all the answers

What happens to neural crest cells during the formation of the neural tube?

<p>They detach from the ectoderm (B)</p> Signup and view all the answers

Which structure differentiates into the brain and spinal cord after neural tube formation?

<p>Neural tube (A)</p> Signup and view all the answers

What structures do the derivatives of the neuroectoderm give rise to?

<p>Neural tube and neural crest (A)</p> Signup and view all the answers

What is the proximal part of the optic vesicle that becomes the optic nerve called?

<p>Optic stalk (A)</p> Signup and view all the answers

What does the mantle zone eventually form during the development of the spinal cord?

<p>Grey matter (B)</p> Signup and view all the answers

Which cell type rapidly divides into neuroepithelial layers during the neural groove stage?

<p>Neuroepithelial cells (A)</p> Signup and view all the answers

The marginal layer of the spinal cord contains what type of fibers?

<p>Nerve fibers from neuroblasts (B)</p> Signup and view all the answers

What do the derivatives of the surface ectoderm NOT give rise to?

<p>Neural tube (B)</p> Signup and view all the answers

How many pairs of cranial nerves arise from the brainstem in humans?

<p>12 pairs (A)</p> Signup and view all the answers

Which structure of the optic vesicle transforms into the retina?

<p>Distal cup (C)</p> Signup and view all the answers

The development of which system begins with the closure of the neural tube?

<p>Nervous system (D)</p> Signup and view all the answers

What type of cells produce the myelin sheath in the peripheral nervous system?

<p>Schwann cells (C)</p> Signup and view all the answers

What is the role of the basal plates in the spinal cord?

<p>They contain ventral motor horn cells. (D)</p> Signup and view all the answers

What is the sulcus limitans?

<p>A longitudinal groove marking the boundary between basal and alar plates. (D)</p> Signup and view all the answers

Which of the following cells is primarily responsible for forming the myelin sheath?

<p>Oligodendroglia cells (D)</p> Signup and view all the answers

At which levels of the spinal cord is the intermediate horn found?

<p>T1-T12 and upper lumbar regions (A)</p> Signup and view all the answers

What type of cells appear during the second half of CNS development and function as phagocytic cells?

<p>Microglial cells (D)</p> Signup and view all the answers

What do axons of neurons in the alar plate primarily form?

<p>Association neurons (interneurons) (D)</p> Signup and view all the answers

What happens to glial blasts after the production of neuroblasts ceases?

<p>They differentiate into ependymal cells. (A)</p> Signup and view all the answers

The marginal layer in the spinal cord is primarily associated with which cell type?

<p>Oligodendroglia cells (A)</p> Signup and view all the answers

What is primarily formed by the neuroblasts in the basal plate?

<p>Motor neurons (C)</p> Signup and view all the answers

Which structure serves as the boundary between the motor and sensory areas of the spinal cord?

<p>Sulcus limitans (D)</p> Signup and view all the answers

What is the result of the fusion of the neural folds during neurulation?

<p>Formation of the neural canal (A)</p> Signup and view all the answers

At which point during development does neurulation begin?

<p>Day 17 (C)</p> Signup and view all the answers

What condition results from incomplete closing of the vertebrae?

<p>Spina bifida (A)</p> Signup and view all the answers

How do the anterior and posterior neuropores differ in their closure timing?

<p>Anterior neuropore closes first (C)</p> Signup and view all the answers

Which part of the neural tube develops into the brain?

<p>Cephalic part (A)</p> Signup and view all the answers

Where are neural crest cells located after detachment during neural tube formation?

<p>Between the surface ectoderm and neural tube (D)</p> Signup and view all the answers

What role does the notochord play in embryonic development?

<p>Induces formation of neural folds (B)</p> Signup and view all the answers

What is a potential consequence of exencephaly?

<p>Brain located outside the skull (B)</p> Signup and view all the answers

What happens during the neurulation process regarding the neural plate?

<p>It bends and forms the neural tube (B)</p> Signup and view all the answers

What structures are derived from the neural crest?

<p>Bones of the face and autonomic ganglia (D)</p> Signup and view all the answers

Which part of the optic vesicle becomes the retina?

<p>Distal cup (A)</p> Signup and view all the answers

What do neuroblasts primarily form during development?

<p>Mantle zone (B)</p> Signup and view all the answers

Which cell type produces the myelin sheath in the peripheral nervous system?

<p>Schwann cells (D)</p> Signup and view all the answers

What is the primary feature of the marginal layer in the spinal cord?

<p>Contains nerve fibers from neuroblasts (A)</p> Signup and view all the answers

During what stage of development do neuroepithelial cells begin to give rise to neuroblasts?

<p>Neural tube stage (D)</p> Signup and view all the answers

What does the mantle zone later develop into?

<p>Grey matter (C)</p> Signup and view all the answers

What is the role of the retina in the eye?

<p>Transmits signals to the brain (D)</p> Signup and view all the answers

What does the optic stalk develop into?

<p>Optic nerve (D)</p> Signup and view all the answers

What is NOT a derivative of surface ectoderm?

<p>Bones of the face (A)</p> Signup and view all the answers

What do the ventral thickening and dorsal thickening of the neural tube develop into?

<p>Basal plates and alar plates (B)</p> Signup and view all the answers

What is the primary function of floor plates and roof plates in the neural tube?

<p>Pathways for nerve fibers (D)</p> Signup and view all the answers

At which levels of the spinal cord is the intermediate horn present?

<p>T1-T12 and upper lumbar (L2 or L3) (D)</p> Signup and view all the answers

What type of cells differentiate from glial blasts primarily found in the mantle layer?

<p>Protoplasmic and fibrillar astrocytes (D)</p> Signup and view all the answers

What is the primary role of oligodendroglia cells in the nervous system?

<p>Production of myelin sheath (D)</p> Signup and view all the answers

Which of the following describes the function of axons from neurons in the basal plate?

<p>Become visible as ventral roots (A)</p> Signup and view all the answers

What cells develop primarily after neuroblasts stop proliferating?

<p>Ependymal cells and glial blasts (D)</p> Signup and view all the answers

Which structure marks the boundary between the basal and alar plates?

<p>Sulcus limitans (A)</p> Signup and view all the answers

What is primarily formed in the alar plate?

<p>Sensory neurones (A)</p> Signup and view all the answers

What do microglial cells primarily do in the central nervous system?

<p>Act as phagocytic cells (A)</p> Signup and view all the answers

Flashcards

Basal Plate

The ventral thickening of the mantle layer, containing ventral motor horn cells that form the motor areas of the spinal cord.

Alar Plate

The dorsal thickening of the mantle layer, forming the sensory areas of the spinal cord.

Sulcus Limitans

A longitudinal groove marking the boundary between the basal and alar plates.

Floor Plate

The midline portion of the neural tube on the ventral side, with no neuroblasts but pathways for nerve fibers.

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Roof Plate

The midline portion of the neural tube on the dorsal side, with no neuroblasts and pathways for nerve fibers.

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Intermediate Horn (Lateral Horn)

A group of neurons found between the ventral motor horn and dorsal sensory horn, containing neurons of the sympathetic nervous system (ANS).

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Adult Nerve Cells (Neurons)

Mature nerve cells that arise from multipolar neuroblasts.

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Oligodendroglia Cells

Primarily found in the marginal layer, these cells form the myelin sheath around axons.

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Glial Blasts

Primitive supporting cells that differentiate into astrocytes and oligodendrocytes.

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Microglial Cells

Phagocytic cells that appear in the second half of CNS development.

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Cell Differentiation and Migration

The process of cell differentiation and migration, leading to the formation of specialized tissues and organs.

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Ectoderm

The outer layer of the embryo that develops into the nervous system, skin, and other structures.

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Neuroectoderm

The portion of the ectoderm that gives rise to the central nervous system, including the brain and spinal cord.

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Neural Tube

A tube-like structure formed from the neuroectoderm, which develops into the brain and spinal cord.

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Neural Crest

A specialized group of cells that migrate from the neural tube and contribute to the development of various structures.

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Surface Ectoderm

The part of the ectoderm that forms the outer layer of skin, hair, nails, and more.

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Optic Cup

A structure formed during brain development, which eventually develops into the retina of the eye.

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Optic Stalk

The portion of the optic vesicle that connects the optic cup to the forebrain, eventually becoming the optic nerve.

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Marginal Layer

The outermost layer of the developing spinal cord, containing nerve fibers.

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Trilaminar Embryonic Disc

The three primary germ layers that form during embryonic development: ectoderm, mesoderm, and endoderm.

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Mantle Layer

The middle layer of the developing spinal cord, which forms the grey matter.

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Notochord

A flexible rod-like structure found in chordate embryos that provides support, defines the body axis, and guides development of the nervous system and vertebrae.

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Neurulation

The process of forming the neural tube, which eventually becomes the brain and spinal cord.

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Neuropores

The openings at the cranial and caudal ends of the neural tube during neurulation.

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Exencephaly

The failure of the anterior neuropore to close during neurulation, resulting in a brain developing outside of the skull.

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Spinal Bifida

The failure of the neural tube to close completely, resulting in a gap in the vertebrae and potential protrusion of spinal cord, nerves, and meninges.

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Neural Crest Cells

A condition where the neural crest cells detach from the ectoderm and migrate to various locations in the body, contributing to the development of various structures.

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Neural Canal

The hollow space within the neural tube that eventually becomes the ventricular system and central canal.

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What is the trilaminar embryonic disc?

The three primary germ layers that form during embryonic development: ectoderm, mesoderm, and endoderm.

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What is the ectoderm?

The outer layer of the embryo that develops into the nervous system, skin, and other structures.

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What is the notochord?

A flexible, rod-like structure found in chordate embryos that provides support, defines the body axis, and guides development of the nervous system and vertebrae.

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What is neurulation?

The process of forming the neural tube, which eventually becomes the brain and spinal cord.

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What are neuropores?

The openings at the cranial and caudal ends of the neural tube during neurulation.

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What is exencephaly?

The failure of the anterior neuropore to close during neurulation, resulting in a brain developing outside of the skull.

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What is spinal bifida?

The failure of the neural tube to close completely, resulting in a gap in the vertebrae and potential protrusion of spinal cord, nerves, and meninges.

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What are neural crest cells?

A specialized group of cells that migrate from the neural tube and contribute to the development of various structures.

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What is the neural canal?

The hollow space within the neural tube that eventually becomes the ventricular system and central canal.

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What is the surface ectoderm?

The part of ectoderm that forms the outer layer of skin, hair, nails, and more.

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Cell Differentiation & Migration in Neural Development

The process by which cells differentiate and migrate to form specialized tissues and organs. This involves the establishment of the neural tube, a crucial structure for the development of the central nervous system.

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Study Notes

Development of the Nervous System

  • During week 3 of embryonic development, the trilaminar embryonic disc consists of three germ layers: ectoderm, mesoderm, and endoderm.
  • The ectoderm develops the central and peripheral nervous systems, as well as parts of the visual system and the epidermis.
  • The notochord, a rod-like structure, provides structural support, defines the body axis, and guides the development of the nervous system and vertebrae in embryos of chordates.
  • Notochord eventually is replaced by the spine in most vertebrates.
  • The notochord stimulates the conversion of overlying surfaces.

Neurulation

  • Neurulation is a process that occurs bidirectionally, starting around day 17 and completing by the end of week 4.
  • Neural tube formation involves the notochord inducing the ectoderm to form the neural plate.
  • The edges of the neural plate fold into neural folds, creating a neural groove.
  • The neural folds fuse, forming the neural tube with a neural canal inside.
  • The neural tube separates from the surface ectoderm eventually producing the brain and spinal cord.
  • Fusion of the neural tube proceeds bidirectionally, with the cranial and caudal ends initially remaining open as neuropores.
  • The posterior neuropore closes two days after the anterior neuropore.
  • The cephalic part of the neural tube forms the brain, and the caudal part forms the spinal cord.
  • Neuropores are the openings of the neural tube.

Neural Tube Defects

  • Exencephaly: A failure of closure of the anterior neuropore, leading to the brain developing outside the skull. This is a precursor to anencephaly.
  • Anencephaly: A condition in which the brain is absent or poorly formed, lacking significant parts or structure.
  • Microcephaly: A condition characterized by a small brain in a small cranium.
  • Spina bifida: Occurs when the neural tube fails to close completely. Incomplete closure can lead to spinal cord and meninges protruding outside the vertebral canal.

Derivatives of the Ectoderm

  • Neuroectoderm: Gives rise to the neural tube (central nervous system - brain and spinal cord), and the neural crest (bones of the face and skull, autonomic ganglia, cranial nerves, and parts of the peripheral nervous system, meninges, and Schwann cells).
  • Surface ectoderm: Develops into the epidermis, hair, nails, enamel of teeth and the anterior lobe of the pituitary gland.

Optic Nerve Development

  • The optic vesicle, an extension of the forebrain, develops into the optic cup (retina) and the optic stalk.
  • The optic stalk becomes the optic nerve.

Development of the Spinal Cord

  • The spinal cord develops during the neural groove stage and immediately after closure of the neural tube.
  • The alar plate gives rise to sensory structures, whereas the basal plate forms motor neuron structures.
  • The sulcus limitans is a groove that marks the boundary between the alar and basal plates.
  • Floor and roof plates are regions of the neural tube that do not contain neuroblasts.

Histological Differentiation: Nerve Cells

  • Multipolar neuroblasts form adult nerve cells (neurons).
  • Axons from cells in the basal plate form ventral roots, responsible for carrying impulses from the spinal cord to muscles.
  • Axons originating in the alar plate penetrate the marginal layer and form association neurons that travel to higher or lower levels.

Histological Differentiation: Glial Cells

  • Glial blasts are produced by neuroepithelial cells after neuroblast production ceases.
  • They differentiate into astrocytes (protoplasmic and fibrillar) for support and blood vessel regulation to neurons.
  • Microglial cells are phagocytic cells in the CNS and appear later in development.
  • Ependymal cells form the lining of the central canal of the spinal cord.

Brainstem

  • The brainstem acts as a direct continuation from the spinal cord and displays similar organisational patterns despite the subtle accentuation of the alar plate and regression of the basal plate.
  • It differs from the spinal cord as the lateral walls are everted, and the alar and basal plate separation is noted.
  • The medulla differs from the spinal cord by having everted lateral walls separated by the sulcus limitans. Basal plates contain motor nuclei, and alar plates contain sensory nuclei.

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