أسئلة المحاضرة السابعة امبريولوجي (قبل التعديل)
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Questions and Answers

What is the process that leads to the development of the nervous system during the third week of development?

  • Neurulation (correct)
  • Folding
  • Primitive streak formation
  • Gastrulation
  • Which part of the ectoderm thickens to form the neural plate during neurulation?

  • Mesoderm
  • Lateral margins of the ectoderm
  • Central ectoderm (correct)
  • Peripheral ectoderm
  • What closes on the 27th day of development during neurulation?

  • Neural plate
  • Caudal neuropore (correct)
  • Cranial neuropore
  • Neural tube
  • Which of the following structures develops from the neural crest cells?

    <p>Ganglia (A)</p> Signup and view all the answers

    Which anomaly is caused by the failure of closure of the cranial neuropore?

    <p>Anencephaly (B)</p> Signup and view all the answers

    What is the effect of folic acid supplementation during pregnancy related to neural tube defects?

    <p>Prevents 70% of defects (B)</p> Signup and view all the answers

    What is the main driving force behind embryonic folding during the fourth week?

    <p>Rapid growth of the neural tube (C)</p> Signup and view all the answers

    Which diagnostic methods are used to identify neural tube defects?

    <p>Alpha-fetoprotein levels and ultrasound (D)</p> Signup and view all the answers

    What role does the notochord play during neurulation?

    <p>It induces the formation of the neural plate. (A)</p> Signup and view all the answers

    Which structure is formed when neural folds fuse during neural development?

    <p>Neural tube (A)</p> Signup and view all the answers

    What characterizes spina bifida occulta among the types of spina bifida?

    <p>It is typically asymptomatic. (A)</p> Signup and view all the answers

    At what stage does the cranial neuropore closure occur?

    <p>On the 25th day (D)</p> Signup and view all the answers

    Which neural crest cell derivative is involved in pigment production?

    <p>Melanocytes (B)</p> Signup and view all the answers

    What is the primary consequence of anencephaly resulting from neural tube defects?

    <p>Absent skull and most brain parts (D)</p> Signup and view all the answers

    What triggers the rapid growth that leads to embryonic folding during the fourth week?

    <p>Development of the neural tube and mesoderm (B)</p> Signup and view all the answers

    Which of the following conditions is known to help prevent neural tube defects during pregnancy?

    <p>Folic acid supplementation (C)</p> Signup and view all the answers

    Explain the role of the notochord in the process of neurulation.

    <p>The notochord acts as an inducer for neurulation, signaling the ectoderm to thicken and form the neural plate.</p> Signup and view all the answers

    Describe one key structural change that occurs during the fusion of neural folds.

    <p>During the fusion, the elevated edges of the neural plate converge and form the neural tube.</p> Signup and view all the answers

    What is a critical time frame for the closure of the caudal neuropore and its significance?

    <p>The caudal neuropore closes on the 27th day, and its closure is crucial to prevent defects in the lower spinal cord.</p> Signup and view all the answers

    Identify the types of spina bifida and their primary distinction.

    <p>Spina bifida can be classified as occulta, meningocele, or meningomyelocele, with occulta being asymptomatic.</p> Signup and view all the answers

    Which nutrients are suggested to help mitigate neural tube defects, and how do they function?

    <p>Folic acid (vitamin B9) supplementation helps prevent neural tube defects by promoting proper neural tube closure.</p> Signup and view all the answers

    Summarize the consequences of anencephaly and its developmental basis.

    <p>Anencephaly results in the absence of a skull and brain parts due to the failure of cranial neuropore closure.</p> Signup and view all the answers

    Discuss how embryonic folding occurs and its significance in development.

    <p>Embryonic folding occurs as the trilaminar embryo folds ventrally due to the rapid growth of the neural tube and mesoderm.</p> Signup and view all the answers

    What are the derivatives of the neural crest cells and their functions?

    <p>Neural crest cells give rise to ganglia, Schwann cells, and melanocytes, serving functions such as nerve signal transmission and pigmentation.</p> Signup and view all the answers

    What role do neural crest cells play during embryonic development?

    <p>Neural crest cells give rise to various structures, including ganglia, Schwann cells, and melanocytes.</p> Signup and view all the answers

    What anatomical change occurs during the process of neurulation?

    <p>During neurulation, the neural plate elevates to form neural folds and creates a neural groove.</p> Signup and view all the answers

    How does spina bifida manifest, and what are its causes?

    <p>Spina bifida is characterized by incomplete closure of the caudal neuropore, leading to spinal cord defects.</p> Signup and view all the answers

    What condition results from the failure of the cranial neuropore to close?

    <p>Anencephaly results from this failure, leading to the absence of most of the brain.</p> Signup and view all the answers

    What is the significance of the notochord during neurulation?

    <p>The notochord acts as an inducer for neurulation, signaling the ectoderm to thicken and form the neural plate.</p> Signup and view all the answers

    In what time frame does the cranial neuropore close, and why is this significant?

    <p>The cranial neuropore closes on the 25th day of development, marking the completion of an essential stage in neural development.</p> Signup and view all the answers

    What role does folic acid play in preventing neural tube defects?

    <p>Folic acid supplementation during pregnancy can prevent approximately 70% of neural tube defects.</p> Signup and view all the answers

    Describe one potential outcome of a neural tube defect detected during pregnancy.

    <p>One outcome could be the diagnosis of spina bifida through elevated alpha-fetoprotein levels.</p> Signup and view all the answers

    Flashcards

    Neurulation

    The development of the nervous system, guided by the notochord, where the ectoderm thickens to form the neural tube and neural crest.

    Neural Tube Formation

    The central ectoderm elevates to form neural folds, which fuse to become the neural tube forming neural tissue.

    Neural Crest

    A collection of cells that migrate and differentiate into various tissues like neurons, connective tissues, and pigment cells.

    Neural Tube Derivatives

    The neural tube forms the brain and spinal cord.

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    Neural Tube Defects

    Birth defects caused by incomplete closure of the neural tube during embryonic development.

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    Anencephaly

    A neural tube defect that leads to the absence of the brain and parts of the skull.

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    Spina Bifida

    A neural tube defect characterized by incomplete closure of the caudal neuropore, often affecting the spinal column.

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    Notochord

    A rod-like structure that induces the formation of the neural tube during neurulation.

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    Neural Plate

    The central part of the ectoderm thickens to form a neural plate, which is the precursor to the nervous system.

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    Neural Fold

    The edges of the neural plate elevate and bend upwards to create neural folds, which eventually fuse together.

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    Neural Groove

    The central depressed area between the neural folds forms the neural groove.

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    Neural Tube

    From the fusion of the neural folds, the neural tube is formed. This structure will develop into the brain and spinal cord.

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    Neural Crest Cells

    These cells originate from the lateral edges of the neural plate at its junction with the rest of the ectoderm. They migrate and differentiate to form a variety of tissues throughout the body.

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    Folic Acid's Role

    Folic acid (vitamin B9) supplementation during pregnancy can prevent 70% of neural tube defects.

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    What is neurulation?

    The process of forming the nervous system from the ectoderm, guided by the notochord. It involves the neural plate, folds, and tube development.

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    What is the notochord's role in neurulation?

    The notochord is the inducer that signals the ectoderm to thicken and form the neural plate, leading to neural tube formation.

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    What does the neural crest become?

    The neural crest, located at the edges of the neural plate, gives rise to various cell types like neurons, pigment cells, and connective tissues.

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    What happens if the neural tube doesn't close completely?

    Incomplete closure of the neural tube during embryonic development can lead to birth defects like anencephaly and spina bifida.

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    What is anencephaly?

    A severe neural tube defect where the brain and parts of the skull are absent, resulting in incompatibility with life.

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    What is spina bifida?

    A neural tube defect where the spinal column doesn't close completely, leading to different types of severity.

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    How can neural tube defects be prevented?

    Folic acid (vitamin B9) supplementation during pregnancy can reduce the risk of neural tube defects by 70%.

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    What is embryonic folding?

    The bending of the trilaminar embryo upon itself ventrally, occurring in the 4th week due to rapid growth of the neural tube and mesoderm.

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    Folic Acid Prevention

    Folic acid (vitamin B9) supplementation during pregnancy can reduce the risk of neural tube defects by 70%.

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    Embryonic Folding

    The bending of the trilaminar embryo upon itself ventrally, occurring in the 4th week due to rapid growth of the neural tube and mesoderm.

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    Study Notes

    Neurulation and Folding

    • Neurulation is the development of the nervous system
    • The notochord induces neurulation
    • Primitive streak formation occurs between days 15 and 16
    • Gastrulation follows primitive streak formation
    • Notochord forms
    • Three germ layers differentiate
    • Ectoderm thickens to form neural plate
    • Neural folds form from the edges of the neural plate
    • Neural folds fuse in the craniocaudal direction to form neural tube
    • Neural crest is a lateral portion of the neural plate

    Fate of Neural tube

    • Cranial neuropore closes on day 25
    • Caudal neuropore closes on day 27
    • Upper part of the neural tube forms brain vesicles
    • Lower part elongates to form spinal cord

    Neural Crest Cells

    • Form various structures including ganglia, pia and arachnoid mater, Schwann cells, chromaffin cells, and melanocytes

    Neurulation Anomalies

    • Anencephaly: Failure of the cranial neuropore to close, resulting in absent skull and brain parts. Incompatible with life.
    • Spina Bifida: Incomplete closure of the caudal neuropore. Classified into occulta (asymptomatic), meningocele, and meningomyelocele.
    • Diagnosis: Elevated alpha-fetoprotein levels and ultrasound.
    • Prevention: Folic acid (vitamin B9) supplementation during pregnancy can prevent 70% of neural tube defects.

    Embryonic Folding

    • Occurs during the fourth week
    • The cause is rapid growth of the developing neural tube and paraxial mesoderm
    • The amniotic cavity expands and surrounds the embryo
    • The yolk sac is constricted into the primitive gut and definitive yolk sac
    • The connection between the primitive gut and definitive yolk sac is the vitellointestinal duct
    • Results:
      • Foregut develops in head folds
      • Midgut develops in lateral folds
      • Hindgut develops in tail folds
      • Yolk sac and Vitello intestinal duct degenerate
      • Lateral body folds fuse to form ventral abdominal wall.

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