Podcast
Questions and Answers
What is the process that leads to the development of the nervous system during the third week of development?
What is the process that leads to the development of the nervous system during the third week of development?
Which part of the ectoderm thickens to form the neural plate during neurulation?
Which part of the ectoderm thickens to form the neural plate during neurulation?
What closes on the 27th day of development during neurulation?
What closes on the 27th day of development during neurulation?
Which of the following structures develops from the neural crest cells?
Which of the following structures develops from the neural crest cells?
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Which anomaly is caused by the failure of closure of the cranial neuropore?
Which anomaly is caused by the failure of closure of the cranial neuropore?
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What is the effect of folic acid supplementation during pregnancy related to neural tube defects?
What is the effect of folic acid supplementation during pregnancy related to neural tube defects?
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What is the main driving force behind embryonic folding during the fourth week?
What is the main driving force behind embryonic folding during the fourth week?
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Which diagnostic methods are used to identify neural tube defects?
Which diagnostic methods are used to identify neural tube defects?
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What role does the notochord play during neurulation?
What role does the notochord play during neurulation?
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Which structure is formed when neural folds fuse during neural development?
Which structure is formed when neural folds fuse during neural development?
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What characterizes spina bifida occulta among the types of spina bifida?
What characterizes spina bifida occulta among the types of spina bifida?
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At what stage does the cranial neuropore closure occur?
At what stage does the cranial neuropore closure occur?
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Which neural crest cell derivative is involved in pigment production?
Which neural crest cell derivative is involved in pigment production?
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What is the primary consequence of anencephaly resulting from neural tube defects?
What is the primary consequence of anencephaly resulting from neural tube defects?
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What triggers the rapid growth that leads to embryonic folding during the fourth week?
What triggers the rapid growth that leads to embryonic folding during the fourth week?
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Which of the following conditions is known to help prevent neural tube defects during pregnancy?
Which of the following conditions is known to help prevent neural tube defects during pregnancy?
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Explain the role of the notochord in the process of neurulation.
Explain the role of the notochord in the process of neurulation.
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Describe one key structural change that occurs during the fusion of neural folds.
Describe one key structural change that occurs during the fusion of neural folds.
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What is a critical time frame for the closure of the caudal neuropore and its significance?
What is a critical time frame for the closure of the caudal neuropore and its significance?
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Identify the types of spina bifida and their primary distinction.
Identify the types of spina bifida and their primary distinction.
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Which nutrients are suggested to help mitigate neural tube defects, and how do they function?
Which nutrients are suggested to help mitigate neural tube defects, and how do they function?
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Summarize the consequences of anencephaly and its developmental basis.
Summarize the consequences of anencephaly and its developmental basis.
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Discuss how embryonic folding occurs and its significance in development.
Discuss how embryonic folding occurs and its significance in development.
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What are the derivatives of the neural crest cells and their functions?
What are the derivatives of the neural crest cells and their functions?
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What role do neural crest cells play during embryonic development?
What role do neural crest cells play during embryonic development?
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What anatomical change occurs during the process of neurulation?
What anatomical change occurs during the process of neurulation?
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How does spina bifida manifest, and what are its causes?
How does spina bifida manifest, and what are its causes?
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What condition results from the failure of the cranial neuropore to close?
What condition results from the failure of the cranial neuropore to close?
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What is the significance of the notochord during neurulation?
What is the significance of the notochord during neurulation?
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In what time frame does the cranial neuropore close, and why is this significant?
In what time frame does the cranial neuropore close, and why is this significant?
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What role does folic acid play in preventing neural tube defects?
What role does folic acid play in preventing neural tube defects?
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Describe one potential outcome of a neural tube defect detected during pregnancy.
Describe one potential outcome of a neural tube defect detected during pregnancy.
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Flashcards
Neurulation
Neurulation
The development of the nervous system, guided by the notochord, where the ectoderm thickens to form the neural tube and neural crest.
Neural Tube Formation
Neural Tube Formation
The central ectoderm elevates to form neural folds, which fuse to become the neural tube forming neural tissue.
Neural Crest
Neural Crest
A collection of cells that migrate and differentiate into various tissues like neurons, connective tissues, and pigment cells.
Neural Tube Derivatives
Neural Tube Derivatives
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Neural Tube Defects
Neural Tube Defects
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Anencephaly
Anencephaly
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Spina Bifida
Spina Bifida
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Notochord
Notochord
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Neural Plate
Neural Plate
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Neural Fold
Neural Fold
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Neural Groove
Neural Groove
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Neural Tube
Neural Tube
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Neural Crest Cells
Neural Crest Cells
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Folic Acid's Role
Folic Acid's Role
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What is neurulation?
What is neurulation?
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What is the notochord's role in neurulation?
What is the notochord's role in neurulation?
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What does the neural crest become?
What does the neural crest become?
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What happens if the neural tube doesn't close completely?
What happens if the neural tube doesn't close completely?
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What is anencephaly?
What is anencephaly?
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What is spina bifida?
What is spina bifida?
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How can neural tube defects be prevented?
How can neural tube defects be prevented?
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What is embryonic folding?
What is embryonic folding?
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Folic Acid Prevention
Folic Acid Prevention
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Embryonic Folding
Embryonic Folding
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Study Notes
Neurulation and Folding
- Neurulation is the development of the nervous system
- The notochord induces neurulation
- Primitive streak formation occurs between days 15 and 16
- Gastrulation follows primitive streak formation
- Notochord forms
- Three germ layers differentiate
- Ectoderm thickens to form neural plate
- Neural folds form from the edges of the neural plate
- Neural folds fuse in the craniocaudal direction to form neural tube
- Neural crest is a lateral portion of the neural plate
Fate of Neural tube
- Cranial neuropore closes on day 25
- Caudal neuropore closes on day 27
- Upper part of the neural tube forms brain vesicles
- Lower part elongates to form spinal cord
Neural Crest Cells
- Form various structures including ganglia, pia and arachnoid mater, Schwann cells, chromaffin cells, and melanocytes
Neurulation Anomalies
- Anencephaly: Failure of the cranial neuropore to close, resulting in absent skull and brain parts. Incompatible with life.
- Spina Bifida: Incomplete closure of the caudal neuropore. Classified into occulta (asymptomatic), meningocele, and meningomyelocele.
- Diagnosis: Elevated alpha-fetoprotein levels and ultrasound.
- Prevention: Folic acid (vitamin B9) supplementation during pregnancy can prevent 70% of neural tube defects.
Embryonic Folding
- Occurs during the fourth week
- The cause is rapid growth of the developing neural tube and paraxial mesoderm
- The amniotic cavity expands and surrounds the embryo
- The yolk sac is constricted into the primitive gut and definitive yolk sac
- The connection between the primitive gut and definitive yolk sac is the vitellointestinal duct
- Results:
- Foregut develops in head folds
- Midgut develops in lateral folds
- Hindgut develops in tail folds
- Yolk sac and Vitello intestinal duct degenerate
- Lateral body folds fuse to form ventral abdominal wall.
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