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Questions and Answers
Which bacterium is primarily responsible for dental caries?
Which bacterium is primarily responsible for dental caries?
What is the primary cause of periodontal disease?
What is the primary cause of periodontal disease?
Which condition is NOT typically treated with antibiotics?
Which condition is NOT typically treated with antibiotics?
What is the common treatment method for a dental abscess?
What is the common treatment method for a dental abscess?
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What causes lactic acid production in the mouth?
What causes lactic acid production in the mouth?
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What is the primary treatment for Actinomyces infections?
What is the primary treatment for Actinomyces infections?
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What condition is specifically associated with an imbalance in the natural microflora of the mouth?
What condition is specifically associated with an imbalance in the natural microflora of the mouth?
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Which of the following organisms is known for causing gastrointestinal infections in humans?
Which of the following organisms is known for causing gastrointestinal infections in humans?
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Which strain of E. coli is known for being enterohaemorrhagic?
Which strain of E. coli is known for being enterohaemorrhagic?
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What is the most common symptom produced by various strains of gastrointestinal pathogens?
What is the most common symptom produced by various strains of gastrointestinal pathogens?
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Which type of infections are typically resistant to prokaryotic-targeting antibiotics?
Which type of infections are typically resistant to prokaryotic-targeting antibiotics?
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In which type of patients is oral thrush most commonly observed?
In which type of patients is oral thrush most commonly observed?
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How many different strains of Escherichia coli are known to exist?
How many different strains of Escherichia coli are known to exist?
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What is the main characteristic of the diarrhoea caused by Enterotoxigenic (ETEC) E.coli?
What is the main characteristic of the diarrhoea caused by Enterotoxigenic (ETEC) E.coli?
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Which bacterial species is known to cause typhoid fever?
Which bacterial species is known to cause typhoid fever?
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What is a common source of Campylobacter infections in humans?
What is a common source of Campylobacter infections in humans?
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How do bacterial toxins from food cause illness?
How do bacterial toxins from food cause illness?
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Which of the following best describes Clostridium botulinum?
Which of the following best describes Clostridium botulinum?
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What is the typical treatment for self-limiting diarrhoea caused by Salmonella enterica?
What is the typical treatment for self-limiting diarrhoea caused by Salmonella enterica?
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What is a potential outcome of E.coli O157:H7 infection?
What is a potential outcome of E.coli O157:H7 infection?
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Which of the following bacteria is the most common cause of diarrhoea in the UK?
Which of the following bacteria is the most common cause of diarrhoea in the UK?
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What is the primary cause of antibiotic-associated diarrhoea?
What is the primary cause of antibiotic-associated diarrhoea?
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Which of the following correctly describes Clostridioides difficile?
Which of the following correctly describes Clostridioides difficile?
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What severe condition can result from a Clostridioides difficile infection?
What severe condition can result from a Clostridioides difficile infection?
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What type of meningitis is most common and typically less severe?
What type of meningitis is most common and typically less severe?
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Which bacterial species is commonly associated with meningitis in children under 5?
Which bacterial species is commonly associated with meningitis in children under 5?
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What is a significant risk factor associated with Clostridioides difficile infections?
What is a significant risk factor associated with Clostridioides difficile infections?
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What is the mortality rate associated with treating infections from Streptococcus pneumoniae in certain age groups?
What is the mortality rate associated with treating infections from Streptococcus pneumoniae in certain age groups?
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Which of the following diseases is NOT caused by Clostridioides difficile?
Which of the following diseases is NOT caused by Clostridioides difficile?
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What percentage of patients are affected by respiratory tract infections related to Haemophilus influenza (Type B)?
What percentage of patients are affected by respiratory tract infections related to Haemophilus influenza (Type B)?
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Which organism is commonly known for causing severe diarrhoea and can remain dormant in a hospital setting?
Which organism is commonly known for causing severe diarrhoea and can remain dormant in a hospital setting?
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What is the main complication associated with E.coli in healthcare settings?
What is the main complication associated with E.coli in healthcare settings?
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Which of the following infections can Klebsiella pneumonia cause?
Which of the following infections can Klebsiella pneumonia cause?
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What is a significant characteristic of MRSA as mentioned in the content?
What is a significant characteristic of MRSA as mentioned in the content?
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Pseudomonas aeruginosa is of concern in healthcare settings primarily due to its association with which type of infection?
Pseudomonas aeruginosa is of concern in healthcare settings primarily due to its association with which type of infection?
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What is one of the biggest killers related to healthcare-associated infections (HAI) in developed countries?
What is one of the biggest killers related to healthcare-associated infections (HAI) in developed countries?
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What is a common infection risk associated with patients on long-term antibiotics?
What is a common infection risk associated with patients on long-term antibiotics?
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Study Notes
Bacterial Infections
- Respiratory tract infections
- Urinary tract infections
- Sexually transmitted diseases
- Gastrointestinal tract infections
- Mouth infections
- Gastrointestinal (GI) tract infections
- Infections
- Food poisoning
- Antibiotic-associated C. difficile infections
- Central nervous system infections (e.g., meningitis)
- Skin, bone, and soft tissue infections (e.g., cellulitis)
- Blood and heart infections (e.g., endocarditis, sepsis)
- Hospital-acquired infections (HAIs) are a significant problem
- HAIs affect a high proportion of patients and hospital staff.
GI Tract Infections (Mouth)
- Caries (Tooth Decay): Caused by Streptococcus mutans which produces lactic acid, leading to tooth decay. Treatment involves fillings or extractions (not antibiotics).
- Abscess: Infection from tooth decay spreading to underlying tissue. Treated with antibiotics and dental treatment.
- Periodontal disease (Gum Disease): Caused by bacteria like Bacteroides and Actinomyces, which colonize the crevice between teeth and gums. Gums become inflamed and bleed, teeth may fall out. Treatment involves good oral hygiene (not antibiotics).
Opportunistic Superinfections of the Mouth
- Oral thrush (Candidiasis): Caused by Candida albicans, an imbalance in the mouth's natural microflora. Seen in immunocompromised patients after antibiotic treatment.
Gastrointestinal Tract Infections
- Viral infections (e.g., rotavirus)
- Protozoa
- Parasites
- Bacterial infections (many species)
- Common examples are Escherichia coli, Salmonella enterica, Shigella, and Campylobacter—Campylobacter being the most common bacterial cause
- Symptoms often include diarrhea (most common symptom)
E. Coli
- 700 different strains
- Commonly lives in the digestive tract and doesn't cause disease
- 200 strains can cause GI disease
- Classified into 6 groups based on how they cause infections
- Enterohaemorrhagic E. coli (EHEC), e.g., H7 and 0157:H7
- Binds to large intestine epithelial cells
- Produces toxins acting directly on cells, excreting fluids, and causing diarrhea
- Can cause hemorrhagic colitis and hemolytic-uremic syndrome (severe)
- Enterotoxigenic E. coli (ETEC)
- Binds to small intestine epithelial cells
- Produces plasmid-associated toxins causing diarrhea (self-limiting)
- Commonly referred to as "traveler's diarrhea"
- Enterohaemorrhagic E. coli (EHEC), e.g., H7 and 0157:H7
Salmonella enterica
- (i) Self-limiting diarrhea
- Sources: raw meat, poultry, eggs, unprocessed milk
- Types: S. enterica Enteritidis and S. enterica Typhimurium
- Bacteria invade small intestine epithelial cells, causing inflammation and diarrhea.
- (ii) Systemic disease: Typhoid fever
- Sources: Contaminated water
- Types: S. enterica serovar Typhi and S. enterica serovar Paratyphi
- Bacteria penetrate gut mucosa, spread to lymph nodes and bloodstream, causing fever and malaise, leading to acute illness
Campylobacter
- Most common cause of diarrhea in humans (from poultry, milk, or water)
- Similar symptoms to salmonellosis, but incubation period may be longer
- Treated with rehydration and antibiotics (e.g., erythromycin)
Food Poisoning
- Bacterial toxins (not bacteria themselves) causing illness.
- Bacteria are often destroyed by cooking but toxins can persist.
- Toxins cause symptoms after reaching the small intestine (diarrhea and vomiting)
- Common causes include:
- Campylobacter jejuni
- Salmonella enterica
- E. coli O157:H7
- Clostridium botulinum
- Bacillus cereus
- S. aureus
Antibiotic-Associated Diarrhea
- Opportunistic superinfection following broad-spectrum antibiotic use
- Overgrowth of Candida albicans or Clostridioides difficile
Clostridioides difficile
- Obligate anaerobic, spore-forming bacteria, resistant to many antibiotics
- Spores are resistant to many disinfectants
- Can overgrow in the gut after broad-spectrum antibiotic use
- Produces toxins causing severe diarrhea, colitis, and toxic megacolon
- A significant concern due to increasing prevalence
Infections of the CNS (Central Nervous System)
- Meningitis (inflammation of meninges)
- Causes include:
- Neisseria meningitidis (most common in children and young adults)
- Streptococcus pneumoniae (most common in young children and adults over 60 with compromised immune systems)
- Haemophilus influenzae (type B) (rare due to vaccine availability)
Infections of the Skin
- Opportunistic infections by skin microflora like Staphylococcus aureus (including MRSA) resulting in:
- Impetigo (spreading infection in epidermis)
- Erysipelas (spreading infection in dermis)
- Boils and folliculitis (infection in or around hair follicles)
- Cellulitis (spreading infection in underlying connective tissue)
- Gangrene (tissue death due to lack of blood flow, often with bacterial involvement)
- Lyme disease (caused by Borrelia burgdorferi, a bacteria transmitted by ticks)
- Causes a red "bullseye" rash along with systemic infection, muscle weakness, arthritis
Infections of Bone and Joints
- Osteomyelitis (S. aureus) - infection located in the growing end of long bones
- Signs: pain, fever, pus in blood vessels
- Slow blood flow (dead areas), biofilms may form
- Septic arthritis (S. aureus) involving joint inflammation
- Signs: pain, swelling, redness, fever
- May follow skin infections (e.g. cellulitis)
Infections of the Heart
- Endocarditis- biofilm infection of inner layers of heart valves
- Caused by Streptococci, Staphylococci, and Enterococci
- Symptoms include temperature, heart murmur
- Diagnosis through electrocardiography, and blood cultures frequently negative.
- Treatment includes penicillin and vancomycin or aminoglycoside.
Sepsis
- Life-threatening condition resulting from a severe bacterial or viral infection in the blood followed by an immune response
- Causes: organ failure, mental health issues, limb loss
- Symptoms: high temp (not always), shivering, slurred speech/confusion, shortness of breath, rapid heart rate, extreme pain, erythrorematous rash
- Treatment: IV antibiotics every hour, quick actions vital
Hospital-Acquired Infections (HAIs)
- 2016-2017: 834,000 HAIs in England, 28,500 deaths.
- HAI: is among the most common causes of preventable death
- 6 most common sites of infection: Bloodstream, GI, respiratory, urinary tract, surgical sites, clinical sepsis.
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Test your knowledge about dental health with this quiz focused on bacteria, diseases, and treatment methods. Explore topics like dental caries, periodontal disease, and dental abscesses. See how much you really know about maintaining a healthy smile!