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Questions and Answers
What is cyclobenzaprine classified as?
What is cyclobenzaprine classified as?
What is the pharmacologic class of cyclobenzaprine?
What is the pharmacologic class of cyclobenzaprine?
Catecholamine reuptake inhibitor
What action does cyclobenzaprine have on muscle activity?
What action does cyclobenzaprine have on muscle activity?
Reduces tonic somatic muscle activity at the level of the brainstem without interfering with general muscle function.
Cyclobenzaprine is indicated for the treatment of muscle spasm associated with acute, painful musculoskeletal conditions for a short-term use of _____ weeks.
Cyclobenzaprine is indicated for the treatment of muscle spasm associated with acute, painful musculoskeletal conditions for a short-term use of _____ weeks.
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List some contraindications for cyclobenzaprine.
List some contraindications for cyclobenzaprine.
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What are some common side effects of cyclobenzaprine?
What are some common side effects of cyclobenzaprine?
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What is the suggested dosing for cyclobenzaprine?
What is the suggested dosing for cyclobenzaprine?
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What should patients be warned about regarding the use of cyclobenzaprine?
What should patients be warned about regarding the use of cyclobenzaprine?
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To enhance therapeutic effects of cyclobenzaprine, patients should consider _____ and physical therapy.
To enhance therapeutic effects of cyclobenzaprine, patients should consider _____ and physical therapy.
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Name a few drug interactions associated with cyclobenzaprine.
Name a few drug interactions associated with cyclobenzaprine.
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Study Notes
Cyclobenzaprine Overview
- Brand names include Amrix®, Fexmid®, and Flexeril®.
- Classified as a centrally acting skeletal muscle relaxant.
Pharmacologic Class
- Functions as a catecholamine reuptake inhibitor.
Mechanism of Action
- Reduces tonic somatic muscle activity primarily at the brainstem level.
- Maintains normal muscle function; shares action similarities with tricyclic antidepressants (TCAs).
Indications for Use
- Prescribed for muscle spasms linked to acute painful musculoskeletal conditions.
- Recommended for short-term use, typically 2-3 weeks.
Contraindications
- Not suitable for those with hypersensitivity to cyclobenzaprine or its components.
- Avoid use during or within 14 days after MAO inhibitor therapy.
- Contraindicated in patients with hyperthyroidism, congestive heart failure, arrhythmias, heart blocks, or during the acute recovery phase of a myocardial infarction (MI).
Side Effects
- Common side effects include palpitations, dry mouth, constipation, nausea, and dizziness.
- Other noted effects: headache, blurred vision, confusion, somnolence, and feelings of nervousness.
- Rare but severe side effects may include cholestasis, hepatitis, jaundice, and anaphylaxis.
Dosing Information
- Extended-release (ER) dosage is 15 mg once daily.
- Initial dosing for immediate-release form is 5 mg administered three times a day (tid).
Patient Education
- Significant drowsiness can occur; patients should avoid driving and hazardous activities.
- Short-term use recommended due to risk of physical dependence.
- Advisable to avoid alcohol and to warn against abrupt discontinuation.
Enhancing Therapeutic Effects
- Suggested measures include immobilizing the affected muscle, applying cold compresses, engaging in whirlpool baths, and undergoing physical therapy.
Drug Interactions
- Contraindicated with MAO inhibitors, anticholinergics, and certain CYP inducers/inhibitors.
- Caution against co-administration with alcohol and serotonin-inducing medications like SSRIs, TCAs, and SNRIs due to the risk of serotonin syndrome.
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Description
Test your knowledge on cyclobenzaprine with these flashcards. Each card covers important aspects such as its pharmacologic class, actions, and brand names. Perfect for students or healthcare professionals looking to enhance their understanding of this muscle relaxant.
