Cyclobenzaprine Flashcards

Study Notes

Cyclobenzaprine Overview

Generic name for the medication is cyclobenzaprine.
Brand names include Amrix and Flexeril.

Medication Classification

Classified therapeutically as a skeletal muscle relaxant.
Pharmacologically categorized as a centrally acting norepinephrine-releasing agent.

Drug Interactions

Concurrent use with CNS depressants or tricyclic antidepressants (TCAs) may lead to enhanced sedative effects.
Combination with phenothiazines and anticholinergic agents can intensify adverse anticholinergic effects.
Risk of fatal hypertensive crisis when used with monoamine oxidase inhibitors (MAOIs).

Uses

Primarily prescribed for short-term management of acute musculoskeletal conditions unrelated to central nervous system (CNS) diseases.
Has off-label use for treating fibromyalgia.

Mechanism of Action

Acts at the brainstem and spinal cord level.
Increases norepinephrine activity by inhibiting its synaptic reuptake, leading to an anticholinergic effect.
Displays central action without direct effects on skeletal muscle.

Side Effects

Common adverse effects include drowsiness and dizziness.
Other notable side effects: xerostomia, cardiovascular effects, orthostatic hypotension, tachycardia, and syncope.
Gastrointestinal disturbances such as nausea, vomiting, diarrhea, anorexia, and flatulence may occur.
Potentially serious reactions include hepatitis, alopecia, tongue and facial edema, and coated tongue with discoloration.

Contraindications

Not recommended for individuals with hypersensitivity to TCAs.
Should be avoided in patients with prolonged QT intervals or those in the recovery stage following a myocardial infarction.

Nursing Considerations

Conduct thorough medical history and physical examination, including vital signs.
Establish baseline neurological status and assess pain levels.
Monitor patients for drowsiness-related injury risk and implement fall precautions.
Check for dermatological reactions such as urticaria, rash, or pruritus.
Advise patients against driving or operating heavy machinery.

Description

This quiz features flashcards about cyclobenzaprine, covering its generic and brand names, classification, and interactions. It is a useful tool for students and healthcare professionals looking to enhance their understanding of this medication.