Podcast
Questions and Answers
Which virus is a member of the Picornaviridae family and is a common etiological agent of the common cold?
Which virus is a member of the Picornaviridae family and is a common etiological agent of the common cold?
What is the primary cell receptor for viral attachment in the pathogenesis of the common cold?
What is the primary cell receptor for viral attachment in the pathogenesis of the common cold?
Which virus can lead to secondary bacterial infections causing mucopurulent secretions in the common cold?
Which virus can lead to secondary bacterial infections causing mucopurulent secretions in the common cold?
Which symptom is less likely to occur with a viral upper respiratory infection?
Which symptom is less likely to occur with a viral upper respiratory infection?
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What can result from the severe blockage of the Sinus ostia or the Eustachian tube in the common cold?
What can result from the severe blockage of the Sinus ostia or the Eustachian tube in the common cold?
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Which family of viruses is the most frequent cause of bronchiolitis?
Which family of viruses is the most frequent cause of bronchiolitis?
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During which seasons do outbreaks of bronchiolitis occur?
During which seasons do outbreaks of bronchiolitis occur?
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How long does viral shedding typically last in immuno-competent individuals?
How long does viral shedding typically last in immuno-competent individuals?
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Which individuals are recommended for perinatal RSV prophylaxis after discharge?
Which individuals are recommended for perinatal RSV prophylaxis after discharge?
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Which age group is at an increased risk of severe infection from bronchiolitis?
Which age group is at an increased risk of severe infection from bronchiolitis?
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What is the mechanism by which Adenovirus interferes with the host antiviral response?
What is the mechanism by which Adenovirus interferes with the host antiviral response?
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What are the clinical manifestations of Adenovirus upper respiratory syndromes?
What are the clinical manifestations of Adenovirus upper respiratory syndromes?
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How is Rhinovirus genomic RNA translated into mature proteins?
How is Rhinovirus genomic RNA translated into mature proteins?
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How does Rhinovirus cause pathogenesis in the upper airways?
How does Rhinovirus cause pathogenesis in the upper airways?
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How is the replication cycle of Rhinovirus initiated?
How is the replication cycle of Rhinovirus initiated?
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Which viral protein of Parainfluenza mediates attachment to host cells through sialic acid?
Which viral protein of Parainfluenza mediates attachment to host cells through sialic acid?
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What is the primary mode of spread of Parainfluenza?
What is the primary mode of spread of Parainfluenza?
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Which age group experiences a peak in RSV infections?
Which age group experiences a peak in RSV infections?
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What is the recommended prophylactic treatment for premature babies at risk of RSV?
What is the recommended prophylactic treatment for premature babies at risk of RSV?
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Which characteristic manifestation helps in diagnosing Croup, a manifestation of Parainfluenza infection?
Which characteristic manifestation helps in diagnosing Croup, a manifestation of Parainfluenza infection?
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Which cellular receptors does Adenovirus use in the respiratory system?
Which cellular receptors does Adenovirus use in the respiratory system?
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What is the characteristic of Adenovirus infection in an infected epithelial cell?
What is the characteristic of Adenovirus infection in an infected epithelial cell?
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Which cells can Adenovirus produce lytic, latent, and transforming infections in?
Which cells can Adenovirus produce lytic, latent, and transforming infections in?
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What is the size range of Adenovirus capsid virus?
What is the size range of Adenovirus capsid virus?
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Which receptors are involved in the activation of type I interferons and inflammatory cytokines by Adenovirus?
Which receptors are involved in the activation of type I interferons and inflammatory cytokines by Adenovirus?
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Which virus causes diseases such as common cold, hand-foot-and-mouth disease, aseptic meningitis, and meningoencephalitis?
Which virus causes diseases such as common cold, hand-foot-and-mouth disease, aseptic meningitis, and meningoencephalitis?
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Which anti-viral drug targets different stages of Coxsackie A virus replication?
Which anti-viral drug targets different stages of Coxsackie A virus replication?
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Which type of coronaviruses contribute to about 10-15% of upper respiratory tract infections and mainly affect infants and children?
Which type of coronaviruses contribute to about 10-15% of upper respiratory tract infections and mainly affect infants and children?
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What is the unique feature that allows Coronaviruses to withstand gastrointestinal conditions and be spread by the fecal-oral route, in addition to the respiratory route?
What is the unique feature that allows Coronaviruses to withstand gastrointestinal conditions and be spread by the fecal-oral route, in addition to the respiratory route?
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What is the incubation period for human coronavirus infections?
What is the incubation period for human coronavirus infections?
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Study Notes
Comparison of Coxsackie A Virus and Human Coronaviruses
- Coxsackie A virus belongs to the Picornavirus family, has a naked, small icosahedral capsid, and causes diseases such as common cold, hand-foot-and-mouth disease, aseptic meningitis, and meningoencephalitis.
- Anti-viral drugs like Arildone, dioxarile, Pleconaril, and ribavirin target different stages of Coxsackie A virus replication.
- Human Coronaviruses have a spherical virion with petal-shaped spikes, and cause diseases similar to the common cold with specific receptors for attachment and entry.
- Coronaviruses interact with the host through non-lytic release by exocytosis and have a strict species specificity for host cell range.
- Human Coronaviruses such as HCoV-229E, HCoV-NL43, HCoV-OC43, and HCoV-HKU1 contribute to about 10-15% of upper respiratory tract infections and mainly affect infants and children.
- The replication cycle of Coronaviruses involves attachment to receptors, entry/fusion, translation of nonstructural proteins, genome transcription and replication, translation of structural proteins, and virion assembly and release.
- The unique "corona" formed by glycoproteins allows Coronaviruses to withstand gastrointestinal conditions and be spread by the fecal-oral route, in addition to the respiratory route.
- Human Coronaviruses prefer an optimum temperature of 33°C-35°C for growth, causing localized upper respiratory tract infections, while zoonotic coronaviruses like SARS-CoV and MERS-CoV can cause systemic disease.
- The incubation period for human coronavirus infections is about 3 days, with the illness lasting between 2 and 18 days, and reinfection is common even in the presence of antibodies.
- Coronaviruses like SARS-CoV2, which cause severe respiratory disease, are zoonotic and can replicate at higher temperatures, leading to systemic disease.
- The replication cycle of Coxsackie A virus involves blocking uncoating of the virus and preventing disassembly of the capsid, while Coronaviruses synthesize 6 individual mRNAs from a minus strand template and assemble virions in the rough endoplasmic reticulum.
- Coxsackie A virus and Coronaviruses have distinct virion structures, genomic architectures, and replication cycles, with differences in disease transmission, host range, and disease epidemiology.
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Description
Test your knowledge of Coxsackie A virus and human coronaviruses with this informative quiz. Explore their virology, replication cycles, diseases, and unique characteristics, and compare their differences in structure, transmission, and epidemiology.
