Inflammatory II
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Questions and Answers

Which one of the following is a chemical mediator of acute inflammation?

  • Vasoactive amines (correct)
  • Free radicals
  • Cytokines
  • Neuropeptides

Which one of the following is a systemic mediator associated with acute inflammation?

  • Lysosomal enzymes
  • Fibrinolytic cascade
  • Complement cascade (correct)
  • Kinin cascade

Which one of the following is a product of the arachidonic acid cascade and functions in an inflammatory response?

  • Nitric oxide
  • Chemokines
  • Inflammatory cytokines
  • Platelet-activating factor (correct)

Which complement component is cleaved into C3a and C3b?

<p>C3 (D)</p> Signup and view all the answers

Which complement component acts as an opsonin on microbial surfaces with specific binding to C3b receptors on macrophages and neutrophils?

<p>C3b (C)</p> Signup and view all the answers

Which complement component induces mast cell release of histamine that contributes to vasodilation and increased vascular permeability?

<p>C5a (A)</p> Signup and view all the answers

Which preformed mediator is widely distributed and is present in the preformed granules of mast cells near vessels, basophils, and platelets?

<p>Histamine (B)</p> Signup and view all the answers

Which enzyme is responsible for the synthesis of prostaglandins and thromboxane from arachidonic acid?

<p>Cyclooxygenase (B)</p> Signup and view all the answers

Which of the following is NOT a product of the lipoxygenase pathway?

<p>Prostacyclin (C)</p> Signup and view all the answers

Which enzyme is inhibited by steroids, thereby preventing the formation of arachidonic acid?

<p>Phospholipase (B)</p> Signup and view all the answers

Which isoform of cyclooxygenase has a beneficial role in protecting the gastric mucosa from acid damage?

<p>Cox 1 (A)</p> Signup and view all the answers

Which of the following is a role of alpha-1 antitrypsin in acute inflammation?

<p>It protects tissue from non-specific digestion (B)</p> Signup and view all the answers

Which cascade produces bradykinin, a potent vasoactive mediator in acute inflammation?

<p>Kinin cascade (D)</p> Signup and view all the answers

What is the purpose of the Coagulation cascade in acute inflammation?

<p>To form a permanent clot in hemostasis (D)</p> Signup and view all the answers

Which cascade counter-regulates the clotting process by degrading fibrin in acute inflammation?

<p>Fibrinolytic cascade (B)</p> Signup and view all the answers

Which cells produce Tumor Necrosis Factor (TNF) and IL-1?

<p>Macrophages, endothelial cells, and mast cells (B)</p> Signup and view all the answers

What is the role of TNF and IL-1 in acute inflammatory events?

<p>All of the above (D)</p> Signup and view all the answers

What are the effects of IL-1, TNF, and IL-6 in the acute-phase reactions?

<p>All of the above (D)</p> Signup and view all the answers

What is the role of chemokines in inflammation?

<p>Mediate chemotaxis of subsets of leukocytes (B)</p> Signup and view all the answers
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