Inflammatory II
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Questions and Answers

Which one of the following is a chemical mediator of acute inflammation?

  • Vasoactive amines (correct)
  • Free radicals
  • Cytokines
  • Neuropeptides
  • Which one of the following is a systemic mediator associated with acute inflammation?

  • Lysosomal enzymes
  • Fibrinolytic cascade
  • Complement cascade (correct)
  • Kinin cascade
  • Which one of the following is a product of the arachidonic acid cascade and functions in an inflammatory response?

  • Nitric oxide
  • Chemokines
  • Inflammatory cytokines
  • Platelet-activating factor (correct)
  • Which complement component is cleaved into C3a and C3b?

    <p>C3</p> Signup and view all the answers

    Which complement component acts as an opsonin on microbial surfaces with specific binding to C3b receptors on macrophages and neutrophils?

    <p>C3b</p> Signup and view all the answers

    Which complement component induces mast cell release of histamine that contributes to vasodilation and increased vascular permeability?

    <p>C5a</p> Signup and view all the answers

    Which preformed mediator is widely distributed and is present in the preformed granules of mast cells near vessels, basophils, and platelets?

    <p>Histamine</p> Signup and view all the answers

    Which enzyme is responsible for the synthesis of prostaglandins and thromboxane from arachidonic acid?

    <p>Cyclooxygenase</p> Signup and view all the answers

    Which of the following is NOT a product of the lipoxygenase pathway?

    <p>Prostacyclin</p> Signup and view all the answers

    Which enzyme is inhibited by steroids, thereby preventing the formation of arachidonic acid?

    <p>Phospholipase</p> Signup and view all the answers

    Which isoform of cyclooxygenase has a beneficial role in protecting the gastric mucosa from acid damage?

    <p>Cox 1</p> Signup and view all the answers

    Which of the following is a role of alpha-1 antitrypsin in acute inflammation?

    <p>It protects tissue from non-specific digestion</p> Signup and view all the answers

    Which cascade produces bradykinin, a potent vasoactive mediator in acute inflammation?

    <p>Kinin cascade</p> Signup and view all the answers

    What is the purpose of the Coagulation cascade in acute inflammation?

    <p>To form a permanent clot in hemostasis</p> Signup and view all the answers

    Which cascade counter-regulates the clotting process by degrading fibrin in acute inflammation?

    <p>Fibrinolytic cascade</p> Signup and view all the answers

    Which cells produce Tumor Necrosis Factor (TNF) and IL-1?

    <p>Macrophages, endothelial cells, and mast cells</p> Signup and view all the answers

    What is the role of TNF and IL-1 in acute inflammatory events?

    <p>All of the above</p> Signup and view all the answers

    What are the effects of IL-1, TNF, and IL-6 in the acute-phase reactions?

    <p>All of the above</p> Signup and view all the answers

    What is the role of chemokines in inflammation?

    <p>Mediate chemotaxis of subsets of leukocytes</p> Signup and view all the answers

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