COPY: Coagulation Disorders - Platelet Disorders Overview

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What is one example of an inherited platelet disorder?

Drug-induced platelet dysfunction

Chronic renal failure

Myeloproliferative disorders

Glanzmann’s Thrombasthenia (correct)

Which of the following is an acquired platelet disorder?

GATA1 mutations

Bernard-Soulier Syndrome

Immune thrombocytopenia (ITP) (correct)

Storage Pool Diseases

What is a distinguishing feature of inherited platelet disorders?

They do not have a genetic basis.

They are only caused by environmental factors.

They primarily affect platelet function.

They always affect platelet numbers. (correct)

Which coud contribute to drug-induced platelet dysfunction?

Specific medication interactions Signup and view all the answers

Which disorder is characterized by a deficiency in ADAMTS13?

Thrombotic Thrombocytopenic Purpura (TTP) Signup and view all the answers

What can be the effect of Glanzmann’s Thrombasthenia on patients?

Excessive bleeding. Signup and view all the answers

Which of the following is NOT a treatment typically available to patients with platelet disorders?

Surgery Signup and view all the answers

What does severe bleeding NOT include?

Mild nosebleeds that resolve quickly Signup and view all the answers

Which of the following describes Idiopathic Thrombocytopenic Purpura (ITP)?

Resulting from the body's immune system destroying platelets Signup and view all the answers

What is a potential major effect of severe bleeding on a patient’s daily life?

Impaired mobility due to bleeding into joints Signup and view all the answers

Which of the following can be a symptom of severe bleeding?

Bleeding episodes occurring multiple times a week Signup and view all the answers

What is the primary genetic cause of Glanzmann’s Thrombasthenia?

Mutations in ITGA2B and ITGB3 Signup and view all the answers

Which test would show no visible platelet aggregation in a patient with Glanzmann’s Thrombasthenia?

Lumi-aggregometry test Signup and view all the answers

What is a notable symptom of Bernard-Soulier Syndrome?

Giant platelets and thrombocytopenia Signup and view all the answers

What does the flow cytometry test reveal in patients with Bernard-Soulier Syndrome?

Decreased levels of GPIb-IX-V complex receptors Signup and view all the answers

Which treatment is approved for Glanzmann’s Thrombasthenia during severe bleeding?

NovoSeven® Signup and view all the answers

What is the approximate platelet count range in patients with Bernard-Soulier Syndrome?

10-100 x 10^9/L Signup and view all the answers

Which genetic mutations cause Bernard-Soulier Syndrome?

Mutations in GPIBA, GPIBB, and GP9 Signup and view all the answers

What condition is characterized by severe bruising and bleeding with normal platelet count?

Glanzmann’s Thrombasthenia Signup and view all the answers

In Glanzmann's Thrombasthenia, how do platelets behave due to the condition?

Platelets fail to bind to each other Signup and view all the answers

What other support is provided for women suffering from Glanzmann's Thrombasthenia?

Hormonal treatment Signup and view all the answers