Platelet and Bleeding Disorders Quiz

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Questions and Answers

Which platelet disorder is characterized by a lighter staining peripheral zone and maintains platelet's discoid shape?

  • Delta granulomere
  • Alpha granulomere
  • Hyalomere (correct)
  • Lambda granulomere

In which stage of hemostasis does the platelet plug occur?

  • Secondary stage
  • Quaternary stage
  • Tertiary stage
  • Primary stage (correct)

What is the range for severe thrombocytopenia?

  • <50,000 (correct)
  • >150,000
  • 100,000-150,000
  • 50,000-99,000

Which condition is characterized by autoantibodies attacking megakaryocytes and platelets?

<p>Immune Thrombocytopenia (C)</p> Signup and view all the answers

Which type of Immune Thrombocytopenia is exclusively found in children?

<p>Acute (D)</p> Signup and view all the answers

What is the primary etiology of Thrombotic Thrombocytopenic Purpura (TTP)?

<p>Deficiency of Metalloprotease ADAMTS13 (B)</p> Signup and view all the answers

Which condition is characterized by microthrombi in affected organs and is different from Hemolytic Uremic syndrome?

<p>Thrombotic Thrombocytopenic Purpura (TTP) (C)</p> Signup and view all the answers

Which infection is associated with the pathologic process of RBC fragmentation in Thrombotic Thrombocytopenic Purpura (TTP)?

<p>Infection of Shigella (D)</p> Signup and view all the answers

Which platelet disorder is characterized by a lighter staining peripheral zone and maintains platelet's discoid shape?

<p>Lambda granule (A)</p> Signup and view all the answers

In which stage of hemostasis does the platelet plug occur?

<p>Primary stage (C)</p> Signup and view all the answers

Which condition is characterized by microthrombi in affected organs and is different from Hemolytic Uremic syndrome?

<p>Thrombotic Thrombocytopenic Purpura (TTP) (C)</p> Signup and view all the answers

Which type of Immune Thrombocytopenia is exclusively found in children?

<p>Acute (B)</p> Signup and view all the answers

Which condition is characterized by autoantibodies attacking megakaryocytes and platelets?

<p>Immune Thrombocytopenia (C)</p> Signup and view all the answers

What is the primary etiology of Thrombotic Thrombocytopenic Purpura (TTP)?

<p>Deficiency of Metalloprotease ADAMTS13 (A)</p> Signup and view all the answers

Which platelet disorder is associated with weaker vessel walls due to perivascular amyloidosis?

<p>Hyalomere (B)</p> Signup and view all the answers

Which type of Immune Thrombocytopenia is common in adult women?

<p>Chronic (B)</p> Signup and view all the answers

Which type of Thrombocytopenia presents within the first 2 days after exposure to heparin?

<p>Type I (A)</p> Signup and view all the answers

Which infection is associated with the pathologic process of RBC fragmentation in Thrombotic Thrombocytopenic Purpura (TTP)?

<p>Shigella (D)</p> Signup and view all the answers

At what platelet count does surgical bleeding typically occur?

<p>$&lt;10,000$ (A)</p> Signup and view all the answers

Which type of Immune Thrombocytopenia is characterized by reduced platelet count and megakaryocytes hyperplasia in bone marrow?

<p>Acute (A)</p> Signup and view all the answers

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Study Notes

Platelet Disorders

  • Grey platelet syndrome is characterized by a lighter staining peripheral zone and maintains platelet's discoid shape.

Hemostasis

  • Platelet plug occurs in the primary hemostasis stage.

Thrombocytopenia

  • Severe thrombocytopenia is characterized by a platelet count of < 20,000/μL.
  • Autoimmune thrombocytopenia is characterized by autoantibodies attacking megakaryocytes and platelets.

Immune Thrombocytopenia

  • Acute Immune Thrombocytopenia is exclusively found in children.
  • Chronic Immune Thrombocytopenia is common in adult women.

Thrombotic Thrombocytopenic Purpura (TTP)

  • Primary etiology of TTP is abnormal processing of von Willebrand factor.
  • Characterized by microthrombi in affected organs and is different from Hemolytic Uremic syndrome.
  • Associated with Escherichia coli (E. coli) infection, which leads to RBC fragmentation.

Other Conditions

  • Amyloid thrombocytopenia is associated with weaker vessel walls due to perivascular amyloidosis.
  • Heparin-induced thrombocytopenia (HIT) presents within the first 2 days after exposure to heparin.
  • Surgical bleeding typically occurs at a platelet count of < 50,000/μL.
  • Idiopathic thrombocytopenic purpura (ITP) is characterized by reduced platelet count and megakaryocytes hyperplasia in bone marrow.

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