24 Questions
Which virus causes paralytic disease mainly targeting anterior horn cells?
Poliovirus
What is the transmission route mainly associated with Poliovirus?
Faeco-oral
Which of the following viruses causes symptoms such as urinary retention, dysaesthesia, paraesthesiae, neuralgia, and motor weakness?
Herpes simplex virus (HSV)
What is the family to which Poliovirus belongs?
Picornaviridae
Which age group is most commonly affected by Poliovirus infection?
Children aged 5-9 years
What is the main target tissue of Poliovirus during epidemics?
Nervous system tissues
Where does the CNS become infected in poliovirus cases?
Medulla and pons
What is the incubation period for poliovirus from acquisition to prodrome?
8-12 days
What are the risk factors for paralysis in poliovirus cases?
Tonsillectomy
What percentage of poliovirus infections experience just the prodrome before becoming non-paralytic polio?
4-8%
Which part of the body is most at risk for paralysis following IM injections in poliovirus cases?
Limb injected or injured
What determines the clinical disease severity in cases of poliovirus infection?
Distribution of lesions
Which of the following is a common clinical feature of aseptic meningitis?
Headache and neck stiffness
What is the main characteristic of CSF findings in bacterial meningitis?
Neutrophil-predominant WBCs
Which virus is not commonly associated with causing viral meningitis?
Influenza virus
What is a distinguishing feature of aseptic meningitis compared to bacterial meningitis?
Presence of rash
What is a common feature of viral meningitis caused by Picornaviridae viruses?
Mononuclear-predominant WBCs in CSF
Which age group is more likely to present with insidious symptoms of bacterial meningitis?
Elderly
What is the gold standard for diagnosing Polio?
CSF viral identification by PCR or culture
Why is it important to identify the viral strain in areas of low Polio incidence?
To differentiate between wild-type and vaccine-related strains
What is the most appropriate management for Polio?
Supportive care
Which of the following symptoms is NOT associated with Polio?
Respiratory centre hyperactivity
What is a common complication of Polio involving paralysis of the diaphragm and intercostal muscles?
Respiratory compromise
In Polio diagnosis, where is the virus most likely to be detected in the first week of illness?
Throat sample
Test your knowledge on common causes of bacterial vs viral meningitis, viral structure, clinical effects, transmission, patient populations, available vaccines, and the characteristics of acute meningitis syndrome.
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