CNS Development Quiz

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Questions and Answers

What is the initial, primary development of the CNS that occurs?

  • Axon growth
  • Neural proliferation
  • Induction of the neural plate (correct)
  • Synapse formation

Consider the development of the CNS. What is the correct order of these stages?

  • Induction of the neural plate, neural proliferation, neural tube formation, axon growth
  • Neural tube formation, induction of the neural plate, neural proliferation, axon growth
  • Induction of the neural plate, neural tube formation, neural proliferation, axon growth (correct)
  • Neural proliferation, neural tube formation, induction of the neural plate, axon growth

Which of the following is NOT a critical step in the development of neurons once they are formed?

  • Migration to the appropriate location
  • Mitotic division (correct)
  • Differentiation
  • Synapse formation

Gene and environmental influences are important to the development of the CNS, but what is especially emphasized in the case of “Genie”?

<p>Environmental factors have a disproportionate impact (B)</p> Signup and view all the answers

What does the example of “Genie” illustrate regarding the role of genes and the environment in the development of the CNS?

<p>Early experiences are critical, and genes have a significant but limited impact. (B)</p> Signup and view all the answers

What are the two key factors that continuously interact throughout the development of the CNS?

<p>Genes and environment (D)</p> Signup and view all the answers

What is a key concept that challenges the traditional view of the brain as a stable organ after childhood?

<p>Brain plasticity (A)</p> Signup and view all the answers

When the neural plate develops, where does the initial signal for the induction come from?

<p>Mesoderm (B)</p> Signup and view all the answers

What is the primary purpose of gastrulation in embryonic development?

<p>To create the three germ layers: ectoderm, mesoderm, and endoderm (D)</p> Signup and view all the answers

What technique is used in the study of zebrafish embryos, as mentioned in the provided references?

<p>Light-sheet fluorescence microscopy (B)</p> Signup and view all the answers

Which of the following is NOT a key factor contributing to the development of the central nervous system (CNS)?

<p>Hormonal regulation (A)</p> Signup and view all the answers

Which of the following is an example of a technique used to visualize neural structures, as mentioned in the references?

<p>All of the above (D)</p> Signup and view all the answers

According to the provided references, what is a major challenge in understanding the development of the CNS?

<p>The complex interaction between genetic and environmental influences on the CNS (A)</p> Signup and view all the answers

During neuronal development, which of the following is NOT a reason for neuronal death?

<p>Insufficient supply of oxygen (C)</p> Signup and view all the answers

Which of the following is NOT a function of neurotrophins?

<p>Trigger the production of myelin (A)</p> Signup and view all the answers

What is the main function of the process of neuronal cell death during development?

<p>To ensure the survival of neurons that form the most accurate connections (D)</p> Signup and view all the answers

Which type of cell death is characterized as a 'clean' process?

<p>Apoptosis (A)</p> Signup and view all the answers

Why are developing neurons considered 'promiscuous' in terms of connections?

<p>They form a large number of connections, some of which may not be essential (C)</p> Signup and view all the answers

Which of the following is NOT a neurotrophin?

<p>Epinephrine (B)</p> Signup and view all the answers

During neuronal development, what is the main outcome of competition for target-supplied neurotrophins?

<p>The stronger neurons survive and refine their connections (A)</p> Signup and view all the answers

What is the significance of the fact that developing neurons make more focused synapses?

<p>It increases the overall accuracy of synaptic connections (B)</p> Signup and view all the answers

According to the Chemoaffinity Hypothesis, how do axons find their target?

<p>Axons grow towards a higher concentration of target-specific chemical labels. (D)</p> Signup and view all the answers

What type of evidence contradicts the Chemoaffinity Hypothesis?

<p>Axons can be successfully guided to their target even when the target is transplanted to a new location. (B)</p> Signup and view all the answers

What is the role of fasciculation in axonal guidance?

<p>Fasciculation is the tendency of axons to follow previously established pathways. (B)</p> Signup and view all the answers

Which of these is NOT an example of evidence supporting the Topographic Gradient Hypothesis?

<p>The hypothesis is supported by in vitro studies examining axonal growth without spatial cues. (A)</p> Signup and view all the answers

Which of these is NOT part of the revised Chemoaffinity Hypothesis?

<p>Axons always form a direct pathway to their target. (D)</p> Signup and view all the answers

What type of cell is crucial for synapse formation?

<p>Glial cell (astrocyte). (D)</p> Signup and view all the answers

Which of the following is a key point in the Topographic Gradient Hypothesis?

<p>It proposes that axonal growth is guided by two intersecting gradients of chemicals. (B)</p> Signup and view all the answers

What is the significance of the fact that the frog optic tectum is homologous to the mammalian superior colliculus?

<p>It suggests that these structures share a common evolutionary origin. (C)</p> Signup and view all the answers

Which of these cell types is considered pluripotent?

<p>Cells from the blastula to the embryonic disk stage (D)</p> Signup and view all the answers

Which of the following is NOT a characteristic of totipotent stem cells?

<p>Can differentiate into multiple cell types within a class of cells (C)</p> Signup and view all the answers

What type of stem cell is responsible for the development of neurons and glia of the peripheral nervous system (PNS)?

<p>Multipotent (A)</p> Signup and view all the answers

Which of the following cell types is NOT a derivative of the neural crest?

<p>Muscle cells (C)</p> Signup and view all the answers

What is the significance of the mesoderm in the development of the neural plate?

<p>The mesoderm triggers the development of the neural plate (D)</p> Signup and view all the answers

What is the main difference between totipotent and pluripotent stem cells?

<p>Totipotent cells can differentiate into any cell type of the body, while pluripotent cells can only differentiate into a limited number of cell types. (A)</p> Signup and view all the answers

Which of the following is an example of a multipotent stem cell?

<p>A cell in the bone marrow that can differentiate into different types of blood cells (C)</p> Signup and view all the answers

What is the significance of a chicken with teeth?

<p>It demonstrates that transplanted mesoderm cells can trigger the development of new tissues. (C)</p> Signup and view all the answers

Which of the following is NOT a type of neural migration?

<p>Horizontal (D)</p> Signup and view all the answers

What is the primary function of cell adhesion molecules (CAMs) in neural development?

<p>Facilitating neuronal migration and adhesion (C)</p> Signup and view all the answers

What is the defining characteristic of "smooth brain" or lissencephaly?

<p>Defects in the cytoskeleton necessary for neuronal migration (C)</p> Signup and view all the answers

What is the primary role of the floor plate and roof plate in neural proliferation?

<p>Providing chemical signals to regulate proliferation (D)</p> Signup and view all the answers

Which disorder is linked to a faulty cell adhesion molecule (CAM) protein?

<p>Kallmann Syndrome (A)</p> Signup and view all the answers

What is the main role of the growth cone in axonal growth?

<p>Extension and retraction of filopodia (D)</p> Signup and view all the answers

Which of the following statements accurately describes how the chemoaffinity hypothesis explains axonal growth?

<p>Axons grow towards target cells that release specific chemical attractants. (D)</p> Signup and view all the answers

What is the correct order of events in neural development, from early to late?

<p>Proliferation, migration, aggregation, axon growth and synapse formation (A)</p> Signup and view all the answers

Flashcards

Prenatal Development

The stage of CNS development that occurs before birth.

Postnatal Development

CNS development that occurs after birth, through childhood to adulthood.

Brain Plasticity

The ability of the brain to change throughout life.

Gametogenesis

The process through which gametes (egg and sperm) are formed.

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Neural Plate Induction

The initial formation of the neural plate from ectoderm due to mesoderm signals.

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Neural Tube

The structure formed from the neural plate that develops into the CNS.

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Neurodevelopment Disorders

Disorders that impact the development of the nervous system, such as Autism and Williams Syndrome.

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Neuron Migration

The process by which neurons move to their designated locations in the brain.

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Neural Crest

A group of cells in embryonic development that can differentiate into various structures, including neurons and glial cells.

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Cellular Differentiation

The process by which stem cells become specialized cell types through specific signals and conditions.

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Stem Cells

Undifferentiated cells with the ability to divide indefinitely and generate different cell types.

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Totipotent Stem Cells

Cells that can differentiate into any cell type and form a complete organism, found in early embryos.

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Pluripotent Stem Cells

Cells that can differentiate into many, but not all, cell types, typically from the inner cell mass of the blastocyst.

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Multipotent Stem Cells

Specialized cells that can develop into multiple cell types within a specific lineage, like blood or nerve cells.

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Unipotent Stem Cells

The most specialized stem cells that can only differentiate into one specific cell type.

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Embryonic Stages

Developmental phases that include the totipotent, pluripotent, and multipotent stages of stem cells before specialization.

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Neural Proliferation

The process by which neural cells multiply and develop, particularly in the neural tube.

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Vesicles Formation

The neural tube initially forms 3 vesicles at 40 days, then 5 vesicles around 50 days.

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Ventricular Zone Proliferation

Most neural cell proliferation occurs in the ventricular zone of the neural tube.

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Chemical Signals in Neural Development

Neural development is regulated by signals from floor and roof plates of the neural tube.

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Types of Neural Migration

Neurons migrate radially, tangentially, or multipolar, guided by chemical signals.

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Cell Adhesion Molecules (CAMs)

Surface proteins on neurons and glia involved in migration and adhesion processes.

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Kallmann Syndrome

A disorder caused by failed neuron migration, leading to abnormal genitals and sense of smell issues.

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Axon Growth Cone

The structure at the tip of a growing axon that helps in finding its target.

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Chemoaffinity Hypothesis

The idea that axons grow towards specific chemical labels in a target area.

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Sperry’s Study

Research demonstrating the chemoaffinity hypothesis through eye rotation in frogs.

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Target Incorrect Innervation

When neurons mistakenly connect to the wrong target after surgical displacement.

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Fasciculation

The tendency of growing axons to follow the paths established by pioneering axons.

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Topographic Gradient Hypothesis

Axonal growth is guided by intersecting chemical gradients on tissues.

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Synaptogenesis

The process of synapse formation between neurons.

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Role of Astrocytes

Glial cells that facilitate synapse formation and support neurons.

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Pioneer Growth Cones

Initial growth cones that navigate using chemical trails towards their targets.

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In vivo studies

Research conducted in living organisms, often using KO mice to study cell signaling.

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Neuron death reasons

Neurons may die due to genetic programming or competition for neurotrophins.

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Apoptosis

Active, clean form of programmed cell death in neurons.

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Necrosis

Passive, dirty form of cell death caused by injury or distress.

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Neurotrophins

Proteins that promote neuron growth and survival, influencing synaptogenesis.

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Neuron connection surplus

Approximately 50% more neurons develop than needed; excess neurons die.

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Synaptic accuracy

Cell death enhances the precision of synapse connections among surviving neurons.

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Functions of neurotrophins

They promote growth, survival, axon guidance, and can trigger synaptogenesis.

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Gastrulation

A critical phase in embryonic development where the embryo reorganizes into three primary cell layers.

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Acetylated α-tubulin

A modified form of tubulin that contributes to the structure of microtubules in cells.

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Zebrafish Embryo

A model organism often used in research for studying developmental processes.

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Light-sheet Fluorescence Microscopy

A microscopy technique that captures images of living specimens with minimal damage.

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Immunostaining

A method used to detect specific proteins in cells or tissues using antibodies.

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