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Questions and Answers
Which of these brain regions has the longest developmental period during postnatal development?
Which of these brain regions has the longest developmental period during postnatal development?
What is the primary event occurring during postnatal development that contributes to the doubling in brain volume?
What is the primary event occurring during postnatal development that contributes to the doubling in brain volume?
Which of these developmental events is NOT considered a key contributor to the development of the CNS after birth?
Which of these developmental events is NOT considered a key contributor to the development of the CNS after birth?
Which of the following executive functions is NOT directly associated with the development of the prefrontal cortex?
Which of the following executive functions is NOT directly associated with the development of the prefrontal cortex?
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What is the relationship between myelination and functional development?
What is the relationship between myelination and functional development?
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Which statement BEST describes the relationship between dendritic branching and neuronal migration?
Which statement BEST describes the relationship between dendritic branching and neuronal migration?
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Which of these brain regions experiences peak synaptogenesis in the first year of life?
Which of these brain regions experiences peak synaptogenesis in the first year of life?
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During postnatal development, what is the primary outcome of pruning or regressive changes?
During postnatal development, what is the primary outcome of pruning or regressive changes?
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Which of these is NOT a known potential function of neurogenesis in adults?
Which of these is NOT a known potential function of neurogenesis in adults?
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Which of these factors listed is NOT considered an extrinsic factor promoting adult neurogenesis?
Which of these factors listed is NOT considered an extrinsic factor promoting adult neurogenesis?
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Which of the following examples, related to experience-induced cortical reorganization, is NOT correlational?
Which of the following examples, related to experience-induced cortical reorganization, is NOT correlational?
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What is the main difference between the examples of cortical reorganization mentioned in the article about the London Taxi drivers and the Violinists, and the example of Phantom Limb Sensation?
What is the main difference between the examples of cortical reorganization mentioned in the article about the London Taxi drivers and the Violinists, and the example of Phantom Limb Sensation?
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Which of the following examples of cortical reorganization directly relates to the brain's ability to adapt to changes in sensory input?
Which of the following examples of cortical reorganization directly relates to the brain's ability to adapt to changes in sensory input?
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What characterizes the changes in the adolescent brain during development?
What characterizes the changes in the adolescent brain during development?
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What is indicated by the term 'neuronal gawkiness' in adolescents?
What is indicated by the term 'neuronal gawkiness' in adolescents?
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Which hormone sensitivity increases in adolescents and plays a role in social bonding?
Which hormone sensitivity increases in adolescents and plays a role in social bonding?
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What developmental direction do changes in the adolescent brain primarily follow?
What developmental direction do changes in the adolescent brain primarily follow?
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Why are adolescents more prone to risk-taking behaviors?
Why are adolescents more prone to risk-taking behaviors?
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Which brain structure undergoes progressive thickening during adolescence?
Which brain structure undergoes progressive thickening during adolescence?
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What social behavior develops significantly during adolescence according to the content?
What social behavior develops significantly during adolescence according to the content?
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What describes the adolescent period in terms of learning and experiences?
What describes the adolescent period in terms of learning and experiences?
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What effect does blindfolding both eyes have on cortical development?
What effect does blindfolding both eyes have on cortical development?
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What was the main finding from the study by Roe et al. (1993) on ferrets?
What was the main finding from the study by Roe et al. (1993) on ferrets?
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How did raising barn owls with prisms affect cortical development?
How did raising barn owls with prisms affect cortical development?
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What was the significance of the study by Li et al. (2017) regarding ocular development?
What was the significance of the study by Li et al. (2017) regarding ocular development?
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What effect does early music training have on the auditory cortex according to Margulis et al. (2009)?
What effect does early music training have on the auditory cortex according to Margulis et al. (2009)?
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What are the implications of axonal pruning during adolescence?
What are the implications of axonal pruning during adolescence?
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Which neurotransmitter-related process is implicated in developmental mechanisms?
Which neurotransmitter-related process is implicated in developmental mechanisms?
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What characteristics are associated with adolescent behavior during brain development?
What characteristics are associated with adolescent behavior during brain development?
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What does high myelination in the brain lead to?
What does high myelination in the brain lead to?
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What role does the subventricular zone play in adult neurogenesis?
What role does the subventricular zone play in adult neurogenesis?
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Which of the following statements about adult neurogenesis is true?
Which of the following statements about adult neurogenesis is true?
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What is the potential function of new cells produced in the dentate gyrus?
What is the potential function of new cells produced in the dentate gyrus?
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What was a significant discovery made by Fernando Nottebohm in 1983?
What was a significant discovery made by Fernando Nottebohm in 1983?
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Why do most newly generated cells in the dentate gyrus die?
Why do most newly generated cells in the dentate gyrus die?
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How does experience-induced cortical reorganization relate to adult neuroplasticity?
How does experience-induced cortical reorganization relate to adult neuroplasticity?
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Which region is responsible for generating new granule cells in adults?
Which region is responsible for generating new granule cells in adults?
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What is the primary factor hindering a 7-12 month old infant's ability to inhibit incorrect responses in an "A not B" task?
What is the primary factor hindering a 7-12 month old infant's ability to inhibit incorrect responses in an "A not B" task?
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In the Wisconsin Card Sorting Test, what task are participants asked to perform?
In the Wisconsin Card Sorting Test, what task are participants asked to perform?
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What is the key outcome observed in adult monkeys with lesions in the prefrontal cortex regarding error perseveration?
What is the key outcome observed in adult monkeys with lesions in the prefrontal cortex regarding error perseveration?
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Which of the following is considered a characteristic of the "use it or lose it" principle in brain development?
Which of the following is considered a characteristic of the "use it or lose it" principle in brain development?
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In the context of early sensory deprivation, what effect is observed on the visual cortex of animals reared in darkness?
In the context of early sensory deprivation, what effect is observed on the visual cortex of animals reared in darkness?
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Which of the following is NOT a characteristic of "permissive experience" in neurodevelopment?
Which of the following is NOT a characteristic of "permissive experience" in neurodevelopment?
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What is a "sensitive period" in neurodevelopment?
What is a "sensitive period" in neurodevelopment?
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What is a key characteristic of a "critical period" in neurodevelopment?
What is a key characteristic of a "critical period" in neurodevelopment?
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Flashcards
Error Perseveration
Error Perseveration
Failure to inhibit an original, learned response that is now incorrect.
A not B Error
A not B Error
A cognitive error where infants search for an object in its original hiding place despite seeing it moved.
Prefrontal Cortex (PFC)
Prefrontal Cortex (PFC)
Brain region involved in planning, decision making, and inhibiting inappropriate responses.
Wisconsin Card Sorting Test
Wisconsin Card Sorting Test
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Permissive Experience
Permissive Experience
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Instructive Experience
Instructive Experience
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Critical Period
Critical Period
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Sensitive Period
Sensitive Period
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Postnatal CNS Development
Postnatal CNS Development
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Synaptogenesis
Synaptogenesis
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Dendritic Branching
Dendritic Branching
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Myelination
Myelination
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Prefrontal Cortex (PFC) Development
Prefrontal Cortex (PFC) Development
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Pruning
Pruning
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Working Memory
Working Memory
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Executive Functions
Executive Functions
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Congenital Bilateral Cataracts
Congenital Bilateral Cataracts
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Cortical Degeneration
Cortical Degeneration
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Medial Geniculate Nucleus
Medial Geniculate Nucleus
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Visual Cortex Reorganization
Visual Cortex Reorganization
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Prism Experiment (Barn Owls)
Prism Experiment (Barn Owls)
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Adolescent Risk-Taking
Adolescent Risk-Taking
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Axonal Pruning
Axonal Pruning
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Neurogenesis
Neurogenesis
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Factors promoting neurogenesis
Factors promoting neurogenesis
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Cortical reorganization
Cortical reorganization
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Transit amplifying cells
Transit amplifying cells
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Pattern separation
Pattern separation
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Axonal Transmission
Axonal Transmission
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Dendritic Pruning
Dendritic Pruning
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Synaptic Strengthening
Synaptic Strengthening
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Cortex Thinning
Cortex Thinning
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Corpus Callosum Thickening
Corpus Callosum Thickening
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Novelty-Seeking
Novelty-Seeking
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Peer Influence
Peer Influence
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Dopamine Sensitivity
Dopamine Sensitivity
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Plasticity in Adolescence
Plasticity in Adolescence
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Adult Neurogenesis
Adult Neurogenesis
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Regions of Neurogenesis
Regions of Neurogenesis
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Olfactory Bulb Function
Olfactory Bulb Function
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Dentate Gyrus Growth
Dentate Gyrus Growth
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Neuroblast Migration
Neuroblast Migration
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Apoptosis of New Neurons
Apoptosis of New Neurons
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Neuroplasticity in Adulthood
Neuroplasticity in Adulthood
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Study Notes
Postnatal Development of the CNS
- The central nervous system (CNS) continues to develop after birth, with significant changes occurring throughout childhood and adolescence.
- Studies of CNS development use nonhuman animals and humans, prenatally and postnatally.
- The brain doubles in volume after birth, but full maturity is not reached until late adolescence.
- The prefrontal cortex (PFC) is the last brain region to develop fully.
- Key postnatal brain developmental processes include synaptogenesis, myelination, dendritic branching, axonal growth, and neurogenesis.
Timeline of Postnatal Brain Development
- Postnatal brain development occurs in stages, with different periods of rapid and prolonged development.
- Differentiation and growth of axons and dendrites, along with the production of synapses and neurotransmitters, are key during early stages.
- Glial cell development and myelination follow, contributing to the speed of neural processes.
- Axon and synapse pruning occur during prolonged development, refining neural connections.
Key Developmental Events
- Dendritic branching follows a pattern of migration, with deeper layers of the brain developing first.
- Synaptogenesis peaks after birth, primarily in the primary visual and auditory cortices within the first year, with the prefrontal cortex developing later.
- Myelination roughly parallels functional development. Sensory areas myelinate first, followed by motor areas, and finally, the prefrontal cortex in adolescence.
- Regressive changes, or pruning, involve synaptic loss and refinement for optimizing function.
Postnatal Development of the Prefrontal Cortex
- Prefrontal cortex development is relatively slow, continuing into late adolescence.
- Its development is linked to the development of higher-level cognitive executive functions, such as organization, self-monitoring, emotional control, flexible thinking, planning, prioritizing, working memory, and task initiation.
Executive Functions of the PFC
- Executive functions of the PFC include working memory, planning, and carrying out sequences of actions, following rules for social behaviours, and context-dependent inhibition of inappropriate responses.
- Deficits in these executive functions can be observed in infants, such as error perseveration.
- Error perseveration in 7–12-month-old infants, often observed in Piaget's "A not B" error, illustrates challenges in inhibiting learned responses that are no longer appropriate in a changed context.
Diamond's Primate Studies
- Studies using infant and adult rhesus macaques reveal that infants, but not adults, show perseverative errors.
- Adult monkeys with prefrontal cortex lesions show similar levels of perseverative errors as infant monkeys, highlighting the PFC's role.
- Wisconsin Card Sorting Test is used with adults to assess frontal lobe function demonstrating perseveration errors in those with frontal lobe damage.
Experience and Neurodevelopment
- Type of experience (permissive versus instructive) and timing (critical versus sensitive periods) influence neurodevelopment.
- Early experiences, such as sensory deprivation or enrichment, directly influence synaptic development and brain structure and function.
- Experience and neurodevelopment can compete. For example, blindfolding one eye can accelerate cortical degeneration in that area.
Early Studies of Experience and Neurodevelopment
- Neurons and synapses that remain unused may not survive.
- Animals raised in the dark show impaired vision and fewer synapses in the visual cortex.
- Enriched environments promote thicker cortices, more synapses, and more dendritic spines in rats.
- Babies with congenital bilateral cataracts often show rapid improvement in vision after removal but may still have some residual deficits.
Experience-induced Cortical Reorganization
- Experience leads to reorganization of sensory and motor maps in the brain.
- Examples include enlarged hand areas in musicians (violinists) and enlarged hippocampi in London taxi drivers.
- Phantom limb sensations and ocular dominance column changes further demonstrate cortical reorganization.
Neurogenesis in Adults
- Neurogenesis, the birth of new neurons, occurs in the adult brain in specific regions.
- Notably the hippocampus, which is important in learning, memory, emotion regulation, and social cognition, has been shown to have neurogenesis capabilities.
- Neurogenesis in adults is vital as it is linked to forming new memories, updating old memories, and adapting to complex environments.
Factors Promoting Adult Neurogenesis
- Intrinsic factors, such as hormones, injury, neurotransmitters, neurotrophins, and aging, influence adult brain neurogenesis.
- Extrinsic factors, such as environmental enrichment, social interaction, physical activity, diet, sleep, and stress, also affect neurogenesis.
- These factors are important in maintaining and promoting neuronal growth and adult brain plasticity.
Neuroplasticity in Adults
- Adult brains retain the capacity for plasticity or changes in neural pathways and connections.
- Neuroplasticity is supported by neurogenesis and experience-induced cortical reorganization.
Possible Mechanisms
- Direct gene regulation; regulation of neurotrophin release; regulation of spontaneously active circuits; and effects of specific neurotransmitters on development underpin the observed changes.
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Description
Explore the intricate stages of postnatal brain development, focusing on the central nervous system's growth after birth. This quiz delves into significant processes such as synaptogenesis and myelination, detailing the timeline of brain maturation through childhood to adolescence.