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Clinical Nutrition: Vitamin B1 (Thiamin) Metabolism

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Clinical Nutrition: Vitamin B1 (Thiamin) Metabolism

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Questions and Answers

What is the role of thiamin pyrophosphate in the body?

Stimulating the production of red blood cells

Acting as a cofactor in the metabolism of pyruvate to acetyl coenzyme A (CoA) (correct)

Supporting the breakdown of lipids into fatty acids

Enhancing muscle contraction and relaxation

Why might subclinical thiamin deficiency be unmasked in malnourished patients when their carbohydrate intake is increased rapidly?

Because thiamin is stored more in fat tissues than carbohydrate tissues

Because rapid increase in carbohydrate intake increases the need for thiamin assimilation (correct)

Because carbohydrates inhibit the absorption of thiamin

Because fat-rich diets increase thiamin requirements

What is the most frequent manifestation of vitamin B1 deficiency in the UK?

Cardiac failure

Sensory polyneuropathy

Encephalopathy (correct)

Wernicke encephalopathy

What is the characteristic feature of Wernicke encephalopathy?

Ophthalmoplegia and ataxia Signup and view all the answers

How does Korsakoff psychosis typically manifest?

Memory loss Signup and view all the answers

What therapeutic response can be used to diagnose Wernicke encephalopathy?

Rapid response to thiamin Signup and view all the answers

Which condition is caused by deficiency of vitamin B1?

Dry beriberi Signup and view all the answers

Study Notes

Thiamin Pyrophosphate

Thiamin pyrophosphate is a crucial cofactor for various enzymes involved in energy metabolism.

Thiamin Deficiency

Subclinical thiamin deficiency may be unmasked in malnourished patients when their carbohydrate intake is increased rapidly, as the increased glucose availability enhances the demand for thiamin.

Vitamin B1 Deficiency in the UK

The most frequent manifestation of vitamin B1 deficiency in the UK is peripheral neuropathy.

Wernicke Encephalopathy

The characteristic feature of Wernicke encephalopathy is a triad of symptoms: ophthalmoplegia, ataxia, and confusion.

Korsakoff Psychosis

Korsakoff psychosis typically manifests as a confusion-abstraction-apathy syndrome, with anterograde and retrograde amnesia.

Diagnostic Response to Wernicke Encephalopathy

A rapid therapeutic response to thiamin administration can be used to diagnose Wernicke encephalopathy.

Vitamin B1 Deficiency Condition

Beriberi is a condition caused by a deficiency of vitamin B1.

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Description

Test your knowledge on the role of thiamin pyrophosphate as a cofactor in various metabolic pathways and the impact of different diets on thiamin assimilation. Explore the implications of subclinical thiamin deficiency in the body.