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Questions and Answers
What is the role of thiamin pyrophosphate in the body?
What is the role of thiamin pyrophosphate in the body?
- Stimulating the production of red blood cells
- Acting as a cofactor in the metabolism of pyruvate to acetyl coenzyme A (CoA) (correct)
- Supporting the breakdown of lipids into fatty acids
- Enhancing muscle contraction and relaxation
Why might subclinical thiamin deficiency be unmasked in malnourished patients when their carbohydrate intake is increased rapidly?
Why might subclinical thiamin deficiency be unmasked in malnourished patients when their carbohydrate intake is increased rapidly?
- Because thiamin is stored more in fat tissues than carbohydrate tissues
- Because rapid increase in carbohydrate intake increases the need for thiamin assimilation (correct)
- Because carbohydrates inhibit the absorption of thiamin
- Because fat-rich diets increase thiamin requirements
What is the most frequent manifestation of vitamin B1 deficiency in the UK?
What is the most frequent manifestation of vitamin B1 deficiency in the UK?
- Cardiac failure
- Sensory polyneuropathy
- Encephalopathy (correct)
- Wernicke encephalopathy
What is the characteristic feature of Wernicke encephalopathy?
What is the characteristic feature of Wernicke encephalopathy?
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How does Korsakoff psychosis typically manifest?
How does Korsakoff psychosis typically manifest?
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What therapeutic response can be used to diagnose Wernicke encephalopathy?
What therapeutic response can be used to diagnose Wernicke encephalopathy?
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Which condition is caused by deficiency of vitamin B1?
Which condition is caused by deficiency of vitamin B1?
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Study Notes
Thiamin Pyrophosphate
- Thiamin pyrophosphate is a crucial cofactor for various enzymes involved in energy metabolism.
Thiamin Deficiency
- Subclinical thiamin deficiency may be unmasked in malnourished patients when their carbohydrate intake is increased rapidly, as the increased glucose availability enhances the demand for thiamin.
Vitamin B1 Deficiency in the UK
- The most frequent manifestation of vitamin B1 deficiency in the UK is peripheral neuropathy.
Wernicke Encephalopathy
- The characteristic feature of Wernicke encephalopathy is a triad of symptoms: ophthalmoplegia, ataxia, and confusion.
Korsakoff Psychosis
- Korsakoff psychosis typically manifests as a confusion-abstraction-apathy syndrome, with anterograde and retrograde amnesia.
Diagnostic Response to Wernicke Encephalopathy
- A rapid therapeutic response to thiamin administration can be used to diagnose Wernicke encephalopathy.
Vitamin B1 Deficiency Condition
- Beriberi is a condition caused by a deficiency of vitamin B1.
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