Clinical Nutrition: Vitamin B1 (Thiamin) Metabolism

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What is the role of thiamin pyrophosphate in the body?

Acting as a cofactor in the metabolism of pyruvate to acetyl coenzyme A (CoA)

Why might subclinical thiamin deficiency be unmasked in malnourished patients when their carbohydrate intake is increased rapidly?

Because rapid increase in carbohydrate intake increases the need for thiamin assimilation

What is the most frequent manifestation of vitamin B1 deficiency in the UK?

Encephalopathy

What is the characteristic feature of Wernicke encephalopathy?

Ophthalmoplegia and ataxia

How does Korsakoff psychosis typically manifest?

Memory loss

What therapeutic response can be used to diagnose Wernicke encephalopathy?

Rapid response to thiamin

Which condition is caused by deficiency of vitamin B1?

Dry beriberi

Study Notes

Thiamin Pyrophosphate

  • Thiamin pyrophosphate is a crucial cofactor for various enzymes involved in energy metabolism.

Thiamin Deficiency

  • Subclinical thiamin deficiency may be unmasked in malnourished patients when their carbohydrate intake is increased rapidly, as the increased glucose availability enhances the demand for thiamin.

Vitamin B1 Deficiency in the UK

  • The most frequent manifestation of vitamin B1 deficiency in the UK is peripheral neuropathy.

Wernicke Encephalopathy

  • The characteristic feature of Wernicke encephalopathy is a triad of symptoms: ophthalmoplegia, ataxia, and confusion.

Korsakoff Psychosis

  • Korsakoff psychosis typically manifests as a confusion-abstraction-apathy syndrome, with anterograde and retrograde amnesia.

Diagnostic Response to Wernicke Encephalopathy

  • A rapid therapeutic response to thiamin administration can be used to diagnose Wernicke encephalopathy.

Vitamin B1 Deficiency Condition

  • Beriberi is a condition caused by a deficiency of vitamin B1.

Test your knowledge on the role of thiamin pyrophosphate as a cofactor in various metabolic pathways and the impact of different diets on thiamin assimilation. Explore the implications of subclinical thiamin deficiency in the body.

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