Clinical Cons of Human Albumin Administration

Questions and Answers

What is the primary concern with human albumin administration?

The parenteral application of albumin is associated with varying degrees of potential hazards

What is the significance of the study by David Solomon-McPhillips, Leonard Nelson, Maximilian Gahr, and Ekaterini T.von Bismarck?

It marked the first use of purified serum albumin

What has changed dramatically over the past nine decades?

The indications for administration of albumin

What is a common problem with human albumin administration in clinical practice?

The cons of albumin administration are commonly disregarded Signup and view all the answers

What is the primary concern with the use of albumin in clinical practice?

The individual risks or benefits of the intervention varying greatly Signup and view all the answers

What is the significance of the observation that only 1 of 114 children treated with albumin exhibited an allergy?

It established the safety of albumin administration in children Signup and view all the answers

What is the main goal of elucidating the pros and cons of human albumin administration?

To inform clinical decisions regarding the use of albumin Signup and view all the answers

What is the main limitation of human albumin administration?

The varying degree of potential hazards associated with parenteral application Signup and view all the answers

What is the primary function of serum albumin in clinical practice?

To compensate for inadequate production or increased losses in critically ill patients Signup and view all the answers

What is the prevalence of allergic reactions in replacement therapy?

16-33% Signup and view all the answers

What is the potential complication of infusing a considerable amount of albumin during fluid resuscitation?

Fluid overload Signup and view all the answers

What is the primary goal of volume resuscitation?

To optimize organ perfusion and function Signup and view all the answers

What is the oncotic effect of albumin?

Every gram of albumin infused retains about 18-20 mL of extravasated fluid Signup and view all the answers

What is the significance of albumin in clinical practice?

It is widely used due to its significant evidence supporting its safety and efficacy Signup and view all the answers

What is the relationship between hypoalbuminemia and excessive albumin administration?

The relationship has not been sufficiently explored Signup and view all the answers

What is the role of albumin in volume expansion?

It is used to enhance the extravasation of interstitial fluid into the vascular lumen Signup and view all the answers

What is the significance of the cutoff value for albumin administration?

It determines the effect of albumin on the cardiovascular system Signup and view all the answers

What is the significance of Tony Startz's discovery?

It showed that albumin can treat polydipsia and polyuria Signup and view all the answers

Study Notes

Clinical Cons of Human Albumin Administration

Human albumin, when administered intravenously, has fewer adverse effects than commonly believed, but its safety is limited by clinical and ethical issues.
The clinical cons of human albumin administration depend on various factors, including the underlying pathology and patient population.

Risk of Allergic Reactions

Human albumin is the most abundant protein in the circulatory system.
Serum albumin is given to compensate for inadequate production or increased losses in critically ill patients.
Allergic reactions to albumin have a prevalence of 16-33% in replacement therapy.
These reactions consist of true allergic reactions and non-immunogenic side effects.

Potential for Fluid Overload

Excess fluid overload can occur due to the accumulation of albumin in circulation during fluid resuscitation.
The rate of infusing albumin should be considered as a potentially causative or contributing factor in fluid overload.
The relationship between hypoalbuminemia and excessive albumin administration has not been sufficiently explored.
Volume expansion can be performed by administering crystalloids or colloids, with albumin being the physiologic natural colloid.
Every gram of albumin infused is able to retain about 18 to 20 mL of extravasated fluid.

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Description

Human albumin administration has fewer adverse effects, but its safety is limited by clinical and ethical issues. Factors like underlying pathology and patient population affect its clinical cons.