Clinical Cons of Human Albumin Administration
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Questions and Answers

What is the primary concern with human albumin administration?

  • The production process of albumin is not standardized
  • The parenteral application of albumin is associated with varying degrees of potential hazards (correct)
  • The albumin molecule itself has potential hazards
  • The storage conditions of albumin affect its safety

    • What is the significance of the study by David Solomon-McPhillips, Leonard Nelson, Maximilian Gahr, and Ekaterini T.von Bismarck?

  • It showed that albumin is contraindicated in malnourished children
  • It established the efficacy of albumin in treating ventilator support
  • It demonstrated the superiority of purified bovine albumin over stored plasma
  • It marked the first use of purified serum albumin (correct)

    • What has changed dramatically over the past nine decades?

  • The production process of albumin
  • The indications for administration of albumin (correct)
  • The molecular structure of albumin
  • The dosage of albumin in clinical practice

    • What is a common problem with human albumin administration in clinical practice?

    <p>The cons of albumin administration are commonly disregarded</p> Signup and view all the answers

    What is the primary concern with the use of albumin in clinical practice?

    <p>The individual risks or benefits of the intervention varying greatly</p> Signup and view all the answers

    What is the significance of the observation that only 1 of 114 children treated with albumin exhibited an allergy?

    <p>It established the safety of albumin administration in children</p> Signup and view all the answers

    What is the main goal of elucidating the pros and cons of human albumin administration?

    <p>To inform clinical decisions regarding the use of albumin</p> Signup and view all the answers

    What is the main limitation of human albumin administration?

    <p>The varying degree of potential hazards associated with parenteral application</p> Signup and view all the answers

    What is the primary function of serum albumin in clinical practice?

    <p>To compensate for inadequate production or increased losses in critically ill patients</p> Signup and view all the answers

    What is the prevalence of allergic reactions in replacement therapy?

    <p>16-33%</p> Signup and view all the answers

    What is the potential complication of infusing a considerable amount of albumin during fluid resuscitation?

    <p>Fluid overload</p> Signup and view all the answers

    What is the primary goal of volume resuscitation?

    <p>To optimize organ perfusion and function</p> Signup and view all the answers

    What is the oncotic effect of albumin?

    <p>Every gram of albumin infused retains about 18-20 mL of extravasated fluid</p> Signup and view all the answers

    What is the significance of albumin in clinical practice?

    <p>It is widely used due to its significant evidence supporting its safety and efficacy</p> Signup and view all the answers

    What is the relationship between hypoalbuminemia and excessive albumin administration?

    <p>The relationship has not been sufficiently explored</p> Signup and view all the answers

    What is the role of albumin in volume expansion?

    <p>It is used to enhance the extravasation of interstitial fluid into the vascular lumen</p> Signup and view all the answers

    What is the significance of the cutoff value for albumin administration?

    <p>It determines the effect of albumin on the cardiovascular system</p> Signup and view all the answers

    What is the significance of Tony Startz's discovery?

    <p>It showed that albumin can treat polydipsia and polyuria</p> Signup and view all the answers

    Study Notes

    Clinical Cons of Human Albumin Administration

    • Human albumin, when administered intravenously, has fewer adverse effects than commonly believed, but its safety is limited by clinical and ethical issues.
    • The clinical cons of human albumin administration depend on various factors, including the underlying pathology and patient population.

    Risk of Allergic Reactions

    • Human albumin is the most abundant protein in the circulatory system.
    • Serum albumin is given to compensate for inadequate production or increased losses in critically ill patients.
    • Allergic reactions to albumin have a prevalence of 16-33% in replacement therapy.
    • These reactions consist of true allergic reactions and non-immunogenic side effects.

    Potential for Fluid Overload

    • Excess fluid overload can occur due to the accumulation of albumin in circulation during fluid resuscitation.
    • The rate of infusing albumin should be considered as a potentially causative or contributing factor in fluid overload.
    • The relationship between hypoalbuminemia and excessive albumin administration has not been sufficiently explored.
    • Volume expansion can be performed by administering crystalloids or colloids, with albumin being the physiologic natural colloid.
    • Every gram of albumin infused is able to retain about 18 to 20 mL of extravasated fluid.

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    Description

    Human albumin administration has fewer adverse effects, but its safety is limited by clinical and ethical issues. Factors like underlying pathology and patient population affect its clinical cons.

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