Cleft Lip and Palate Etiology and Development

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29 Questions

During which weeks of pregnancy does the lip form?

4th and 7th weeks

Which failure of fusion leads to the formation of the primary palate?

Intermaxillary segment with maxillary process

At what stage is cleft lip typically detected on ultrasound?

13th week of pregnancy

What is the cause of cleft palate?

Failure of lateral palatine shelves to fuse

Which structure is affected by a cleft palate?

Roof of the mouth (palate)

What are some common issues associated with cleft lip?

Speech issues, feeding issues, oral hygiene issues

In which stage of pregnancy is the roof of the mouth (palate) formed?

6th and 9th weeks

What structures are formed by the first pharyngeal pouch?

Portions of the inner ear

Which cranial nerve is responsible for sensation in the first pharyngeal arch?

CN V-5

Which gland is formed from the ventral part of the third pharyngeal pouch?

Thymus

What is the main cause of Treacher Collins Syndrome?

Failure of neural crest cell migration

Which cranial nerve is associated with taste in the second pharyngeal arch?

CN VII-7

In Treacher Collins Syndrome, which of the following facial bones are typically underdeveloped?

Mandible and jaw

Which glandular structure is formed by the ultimobranchial body from the fourth pharyngeal pouch?

Calcitonin-producing C-cells

Which of the following is a classic triad associated with DiGeorge Syndrome?

Loss of thymus, loss of parathyroid glands, congenital heart defects

Which pharyngeal pouches are affected in Arytenoid DiGeorge Syndrome?

3rd and 4th pharyngeal pouches

Which structure is derived from the 1st pharyngeal cleft?

External auditory meatus

A mass located below the angle of the mandible and anterior to the sternocleidomastoid muscle is most likely a result of which condition?

Branchial cleft cyst

Which craniofacial malformation is considered the most common?

Cleft lip

What is a distinguishing feature between a Branchial cleft cyst and a thyroglossal duct cyst?

Ability to move with swallowing

Which cranial nerve is primarily involved in innervating the muscles of mastication?

Cranial Nerve V (Trigeminal)

Which embryonic structure is key for the development of the head and neck?

Pharyngeal arches

From which pharyngeal arch does the Mandibular Process give rise to the Mandible?

1st arch

Which nerve is associated with the development of the Muscles of Mastication?

CN V (5)

Which structure is derived from Reichert’s Cartilage of the 2nd Arch?

Stapes

The Posterior Digastric muscle is innervated by which cranial nerve?

CN VII (7)

Which embryonic vessel is involuted in development and does not persist into adulthood?

Stapedial Artery

Which pharyngeal arch gives rise to the Laryngeal muscles?

4th Arch

'Treacher Collins Syndrome' mainly affects which structures in the head and neck?

'1st Arch: forms the face' statement

Explore the multifactorial etiology of cleft lip and palate, including environmental factors, medications, vitamin deficiencies, obesity, and genetic influences. Understand the developmental process of cleft lip and palate formation during pregnancy, involving the failure of fusion of specific facial segments. Learn about ultrasound detection of these conditions in the 13th week of pregnancy.

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