Ciprofloxacin Overview and Applications

Podcast

Play an AI-generated podcast conversation about this lesson

Download our mobile app to listen on the go

Get App

Questions and Answers

What is the primary use of ciprofloxacin in dental applications?

Pain relief during dental procedures
Treatment of systemic infections
Management of periodontal infections (correct)
Relief from tooth sensitivity

Which of the following bacteria is NOT typically treated with ciprofloxacin?

Pseudomonas aeruginosa
Escherichia coli
Methicillin sensitive Staphylococcus aureus (correct)
Streptococcus pneumoniae

Which of the following is a possible adverse effect of ciprofloxacin?

Tachycardia
Excessive salivation
Lowered blood pressure
Photosensitivity (correct)

What is the role of ciprofloxacin in treating urinary tract infections?

Effective against Gram negative organisms (B)

Signup and view all the answers

For which condition is ciprofloxacin combined with metronidazole?

Genitourinary tract infections (B)

Signup and view all the answers

What is NOT a common therapeutic use for ciprofloxacin?

HIV infection (B)

Signup and view all the answers

Which bacteria is associated with acute cholecystitis that ciprofloxacin targets?

Klebsiella pneumoniae (D)

Signup and view all the answers

Which of the following infections related to the gastrointestinal tract can be treated with ciprofloxacin?

Traveller's diarrhoea caused by Escherichia coli (C)

Signup and view all the answers

Flashcards

Ciprofloxacin

A fluoroquinolone antibiotic that effectively targets gram-positive and gram-negative bacteria.

Mechanism of action of Ciprofloxacin

Ciprofloxacin disrupts the bacterial DNA replication process, preventing the growth and multiplication of pathogens.

Mechanism of resistance to Ciprofloxacin

Bacteria can develop resistance mechanisms against Ciprofloxacin, such as mutations in DNA gyrase, the key enzyme targeted by the drug.

Antimicrobial spectrum of Ciprofloxacin

Ciprofloxacin effectively targets a wide variety of bacteria, including E. coli, S. pneumoniae, P. aeruginosa, and many others.

Signup and view all the flashcards

Routes of administration for Ciprofloxacin

Ciprofloxacin can be administered via intravenous injection, oral tablets, or eye drops, depending on the infection site and severity.

Signup and view all the flashcards

Adverse drug reactions to Ciprofloxacin

Common side effects of Ciprofloxacin include nausea, diarrhea, headache, and tendon inflammation. Rare side effects include liver damage and allergic reactions.

Signup and view all the flashcards

Therapeutic uses of Ciprofloxacin

Ciprofloxacin is used to treat a variety of bacterial infections, including skin infections, respiratory infections, urinary tract infections, and gastrointestinal infections.

Signup and view all the flashcards

Combinations of Ciprofloxacin

Ciprofloxacin can be combined with other antibiotics, like Ampicillin and Metronidazole, to treat complex infections involving multiple bacterial species.

Signup and view all the flashcards

Study Notes

Ciprofloxacin

Ciprofloxacin is a fluoroquinolone antibiotic.
It is effective against Gram-negative bacteria, with moderate activity against Gram-positive bacteria.
Uses for ciprofloxacin include:
- Dental infections: periodontitis, pericoronitis, gingivitis, acute necrotizing ulcerative gingivitis. Other drugs used in combination include Ofloxacin, Moxifloxacin, and Ciprofloxacin + Tinidazole.
- Skin and soft tissue infections (caused by Methicillin-resistant Staphylococcus aureus)
- ENT infections (caused by Streptococcus pneumoniae, Enterobacter, Haemophilus influenzae and Pseudomonas aeruginosa)
- Respiratory tract infections (caused by Methicillin-resistant Staphylococcus aureus, Streptococcus pneumoniae, Moraxella catarrhalis, Escherichia coli, Enterobacter species, Klebsiella pneumoniae, Haemophilus influenzae and Serratia)
- Acute cholecystitis (caused by Klebsiella pneumoniae and Escherichia coli)
- Gastrointestinal issues (such as Traveler's diarrhea, enteric fever, acute gastroenteritis, cholera)
- Liver and intraperitoneal abscesses (caused by Bacteroides fragilis)
- Genitourinary tract infections (caused by Neisseria gonorrhoeae, Enterobacter species, Proteus mirabilis, Klebsiella pneumoniae, Serratia, Pseudomonas aeruginosa and Haemophilus influenzae)
- Meningitis (caused by Neisseria meningitides, Enterobacter species and Campylobacter fetus)
- Bone and joint infections (caused by Escherichia coli, Pseudomonas aeruginosa and Methicillin-resistant Staphylococcus aureus)
- Endocarditis and bacteremia (caused by Methicillin-resistant Staphylococcus aureus and Campylobacter fetus)
- Other infections: Bacteremia (caused by Bacteroides fragilis) Eye infection and cystic fibrosis (caused by Pseudomonas aeruginosa), Wound infections (caused by Pasteurella multocida), Chancroid (caused by Haemophilus ducreyi).
Ciprofloxacin is used in combination with other drugs for various conditions.
The document also mentions biological warfare agents, such as anthrax (Bacillus anthracis) and plague (Yersinia pestis), where Ciprofloxacin may be used. There are other conditions mentioned in the document like Chlamydial infections (urethritis and cervicitis due to Chlamydia trachomatis), Mycobacterium infections (tuberculosis, disseminated Mycobacterium Avium Complex), and prophylactic uses.