Summary

This document details the various uses of Ciprofloxacin, an antibiotic, for treating different types of bacterial infections. It covers its applications in dental procedures, skin infections, respiratory tract issues, and more. The document also touches on the use of Ciprofloxacin in prophylaxis and warfare contexts.

Full Transcript

CIPROFLOXACIN gram negative bacteria and moderate It is a fluoroquinolone having excellent activity on activity on gram positive bacteria. Refer Text for: " Mechanism of action Mechanism of resistance...

CIPROFLOXACIN gram negative bacteria and moderate It is a fluoroquinolone having excellent activity on activity on gram positive bacteria. Refer Text for: " Mechanism of action Mechanism of resistance Antimicrobial spectrum " Routes of administration " Adverse drug reactions " Therapeutic uses 1. Dental Uses 1. Periodontal infections - Periodontitis, Pericoronitis, gingivitis, acute necrotizing ulcerative gingivitis. Other drugs used - Ofloxacin, Moxifloxacin, Ciprofloxacin + Tinidazole. 2. Bacterial infections 1. Skin and soft tissue infections due to Methicillin resistant Staphylococcus aureus. 2. ENT infections due to Streptococcus pneumoniae, Enterobacter species, Haemophilus influenzae and Pseudomonas aeruginosa. 3. Respiratory tract infection due to Methicillin resistant Siaphylococcus aureus. Streptococcus pneumoniae, Moraxella catarrhalis, Escherichia coli, Enterobacter species, Klebsiella pneumoniae, Haemophilus influenzae and Serratia. 4. Acute cholecystitis due to Klebsiella pneumoniae and Escherichia coli. 5. GIT Traveller's diarrhoea due to Escherichia coli and Campylobacter jejuni. Enteric fever due to Salmonella typhi and Salmonella paratyphi. Acute gastroenteritis due to Shigella and Campylobacter jejuni. Cholera due to Vibrio cholerae. 6. Liver and intraperitoneal abscess due to Bacteroides fragilis. - Ciprofloxacin + Ampicillin t Metronidazole 7. Genitourinary tract infection due to Neisseria gonorrhoeae, Enterobacter species, Proteus mirabilis, Klebsiella pneumoniae, Serratia, Pseudomonas aeruginosa and Haemophilus influenzae Ciprofloxacin Escherichia coliand Bacteroides fragilis -Ciprofloxacin + Ampicillin + Metronidazole 8. Meningitis due to Neisseria meningitides, Enterobacter species and Campylobacter fetus. 9. Bone and joint infections due to Escherichia coli. Pseudomonas aeruginosa and Methicillin resistant Staphylococcus aureus. 10. Endocarditis and Bacteremia due to Methicillin resistant Staphylococcus aureus and Campylobacter fetus. U. Bacteremia due to Bacteroides fragilis. Ciprofloxacin + Ampicillin + Metronidazole 12. Eye infection and cystic fibrosis due to Pseudomonas aeruginosa. 13. Wound infection due to Pasteurellamultocida. 14.Chancroid due to Haemophilus ducreyi. 15. Biological warfare Anthrax due to Bacillus anthracis Plague due to Yersinia pestis Brucellosis due to Brucella - Ciprofloxacin + Rifampicin Tularemia due to Francisella tularensis 16. Legionnaires' disease due to Legionella pneumophila 3. Chlamydial infections 1. Urethritis and cervicitis due to chlamydia trachomatis. 4. Mycobacterium infections 1. Tuberculosis due to Mycobacterium tuberculosis. 2. Disseminated Mycobacterium Avium Complex -MAC in AIDS patients due to Mycobacterium avium-intracellulare. 3. Mycobacterium kansasi, fortuitum, malmoense and haemophilum infections. 5. Prophylactic uses 1. Biological warfare: Anthrax due to Bacillus anthracis and Plague due to Yersinia pestis. 2. Peritonitis due to Escherichia coli. 3 Meningitis due to Neisseria meningitides. 4 Surgical prophylaxis.

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