Cholinergic Transmission and Parasympathomimetics

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Questions and Answers

What is the effect of low doses of atropine on the heart rate?

  • Tachycardia
  • Arrhythmia
  • No effect
  • Bradycardia (correct)

What is the name of the device used to administer scopolamine for motion sickness?

  • Transderm Scop (correct)
  • Scopderm
  • Belladona Patch
  • Atropine Trolley

What is the Italian phrase for 'beautiful lady' that is associated with atropine?

  • Bella donna
  • Belladona (correct)
  • Dolce vita
  • Bella vita

What is the effect of atropine on the eye in patients with glaucoma?

<p>Increases intraocular pressure (B)</p>
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What is the therapeutic application of atropine in emergency situations?

<p>Management of emergency bradycardia (B)</p>
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What is the primary effect of scopolamine on the central nervous system?

<p>Anticholinergic effects (C)</p>
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What is the primary limitation of using Acetylcholine as a therapeutic agent?

<p>It is rapidly broken down by enzymes in the synaptic cleft (B)</p>
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Which of the following is a characteristic of indirectly acting cholinergic agonists?

<p>They inhibit the breakdown of Acetylcholine by enzymes (C)</p>
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What is the primary mechanism of action of Pilocarpine?

<p>Binding directly to muscarinic acetylcholine receptors (C)</p>
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Which of the following is a nicotinic acetylcholine receptor antagonist?

<p>Edrophonium (A)</p>
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What is the primary difference between directly and indirectly acting cholinergic agonists?

<p>Their mechanism of action on cholinergic neurons (C)</p>
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What is the therapeutic use of Neostigmine?

<p>Treating myasthenia gravis (B)</p>
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What is the primary mechanism of action of circulating antibodies in myasthenia gravis?

<p>Blocking acetylcholine receptors at the postsynaptic neuromuscular junction (C)</p>
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What is the purpose of administering edrophonium chloride in the diagnosis of myasthenia gravis?

<p>To increase the levels of acetylcholine at the neuromuscular junction (D)</p>
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What is the primary therapeutic application of scopolamine?

<p>Treatment of motion sickness (C)</p>
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What is the primary action of cholinesterase inhibitors in the treatment of myasthenia gravis?

<p>Directly improving muscle function (A)</p>
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What is the primary mechanism of action of parasympatholytics?

<p>Blocking the actions of acetylcholine at the muscarinic receptors (D)</p>
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What is the primary nursing implication related to the use of parasympatholytic drugs?

<p>Monitoring for anticholinergic side effects (C)</p>
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What is the therapeutic application of Pilocarpine?

<p>Lowering of IOP in chronic simple glaucoma (C)</p>
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What is the reason why acetylcholine is therapeutically of no importance?

<p>It has a multiplicity of actions (A)</p>
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Which drug is used to treat conditions associated with increased muscle tone?

<p>Botulinum toxin (B)</p>
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What is the mechanism of action of Botulinum toxin?

<p>Inhibition of ACh release (D)</p>
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What is the primary effect of pilocarpine on the eye when applied topically?

<p>Miosis and contraction of the ciliary body (D)</p>
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Which drug is used to relieve abdominal pain in colics?

<p>Buscopan (A)</p>
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What is the primary use of neostigmine in medical therapy?

<p>To treat myasthenia gravis (B)</p>
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What is the therapeutic application of Scopolamine?

<p>Motion sickness and relieve spasms and colics (B)</p>
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What is the primary adverse effect of pilocarpine hydrochloride 1% ophthalmic solution?

<p>Spasm of accommodation (C)</p>
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What is the term for the 'grave muscle weakness' disease that is treated with neostigmine?

<p>Myasthenia gravis (D)</p>
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What is the mechanism of action of Neostigmine?

<p>Enzymatic inactivation of AChE (D)</p>
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What is the primary effect of acetylcholine on the heart rate?

<p>Decrease (D)</p>
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