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Choline Transport and Cevimeline Uses

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Questions and Answers

What is a potential cardiovascular side effect mentioned?

Bradycardia (correct)

Tachycardia

Hypertension

Arrhythmia

Which of the following is NOT a cardiovascular side effect related to the content?

Dizziness

Hypotension

Bradycardia

Palpitations (correct)

Which cardiovascular effect is associated with low blood pressure?

Vasoconstriction

Tachycardia

Bradycardia

Hypotension (correct)

What is a common consequence of bradycardia?

Decreased cardiac output Signup and view all the answers

Which of the following correctly describes hypotension?

Low blood pressure Signup and view all the answers

What type of transport is used for choline to enter cholinergic neurons?

Active transport Signup and view all the answers

Why cannot choline diffuse freely through the membrane?

It carries a positive charge due to its quaternary nitrogen. Signup and view all the answers

What characteristic of choline affects its transport into neurons?

Its quaternary nitrogen and positive charge Signup and view all the answers

What does the active transport of choline require?

Energy from ATP Signup and view all the answers

Which of the following best describes the mechanism responsible for choline transport into cholinergic neurons?

Energy-dependent carrier system Signup and view all the answers

Study Notes

Choline Transport

Choline is actively transported into cholinergic neurons via energy-dependent carriers.
Due to its quaternary nitrogen and positive charge, choline cannot diffuse across cell membranes.

Side Effects

Cardiovascular effects include bradycardia and hypotension, primarily via M2 receptors.
Tertiary amine alkaloids are non-polar and lipid-soluble, allowing passage through the blood-brain barrier (BBB) with potential CNS side effects.
Cevimeline (Evoxac®) is resistant to hydrolysis by cholinesterase enzymes.

Cevimeline (Evoxac®) Uses

Administered orally to treat dry eyes and dry mouth (xerostomia) associated with Sjögren's syndrome.

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Description

This quiz covers the mechanisms of choline transport into cholinergic neurons and the pharmacological effects of Cevimeline, including its applications for treating dry eyes and mouth in Sjögren's syndrome. It also addresses cardiovascular side effects and the properties of tertiary amine alkaloids. Test your knowledge on these important topics in neuropharmacology.