Choline and DPPC in Lung Surfactant Quiz

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Which type of glycosphingolipid is negatively charged at physiologic pH due to the presence of N-acetylneuraminic acid?

Ceramide

Cerebrosides

Gangliosides (correct)

Sulfatides

In which tissue are gangliosides primarily found?

Kidney

Nerve tissue (correct)

Myelin sheath

Peripheral nervous tissue

What is the role of sulfatides in cerebrosides?

Found predominantly in the brain

Negatively charged at physiologic pH

Primary synthesis in Golgi apparatus

Contain sulfated galactosyl residues (correct)

Which compound serves primarily as an intermediate in the synthesis and degradation of glycosphingolipids?

Glucocerebroside Signup and view all the answers

What provides the negative charge in acidic glycosphingolipids at physiologic pH?

N-acetylneuraminic acid Signup and view all the answers

Which type of fatty acid is attached to the sphingosine in glycosphingolipids found predominantly in the brain?

Type of fatty acid varies Signup and view all the answers

Where are gangliosides derivatives primarily found?

Central nervous system Signup and view all the answers

Which part of the nerve cells is rich in gangliosides?

Synaptic terminals Signup and view all the answers

What is the main interest in lipid storage disorders involving glycosphingolipids?

Accumulation of NANA-containing glycosphingolipids Signup and view all the answers

In glycosphingolipids, what provides the negative charge in acidic glycosphingolipids at physiologic pH?

N-acetylneuraminic acid Signup and view all the answers

Where does the synthesis of glycosphingolipids primarily occur?

Golgi apparatus Signup and view all the answers

What type of fatty acid is attached to the sphingosine in glycosphingolipids found predominantly in the brain?

Saturated fatty acids Signup and view all the answers

Which organelle is responsible for the degradation of glycosphingolipids?

Lysosomes Signup and view all the answers

What is the primary function of sulfatides in nerve tissue?

Serve as negative charge carriers Signup and view all the answers

Which part of the nerve cells contains the most complex glycosphingolipids?

Myelin sheath Signup and view all the answers

What differentiates gangliosides from acidic glycosphingolipids?

$Linkage with N-acetylneuraminic acid$ Signup and view all the answers

What is the key role of N-acetylneuraminic acid (NANA) in glycosphingolipids?

$Provide negative charge$ Signup and view all the answers

Where is the highest concentration of cerebrosides found in the body?

Nerve tissue Signup and view all the answers