Chimeric Monoclonal Antibodies in Biotechnology

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Questions and Answers

What are chimeric antibodies composed of?

  • Entirely murine antibody sequence
  • Human variable parts and murine constant parts
  • Entirely human IgG sequence
  • Human constant parts and murine variable parts (correct)

How are chimeric antibodies produced?

  • By fusing B cells from an immunized mouse with myeloma cells to construct hybridoma (correct)
  • By isolating DNA sequences coding human VH and VL from the clone
  • By using entirely human immunoglobulin constant regions from mouse cells
  • By isolating DNA sequences coding mouse VH and VL from human cells

What percentage of the human Ig sequence do hybrid antibodies composed of 75% of the human Ig sequence contain?

  • 50%
  • 100%
  • 75% (correct)
  • 25%

What is used to obtain hybrid antibodies composed of 75% of the human Ig sequence?

<p>$cDNAs$ encoding the heavy and light chains in one (or two) expression vector(s) (C)</p> Signup and view all the answers

What is transfected into mammalian cells to produce chimeric antibodies?

<p>$Mouse/human$ chimeric genes constructed by genetic engineering (B)</p> Signup and view all the answers

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