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Questions and Answers
What are chimeric antibodies composed of?
What are chimeric antibodies composed of?
- Entirely murine antibody sequence
- Human variable parts and murine constant parts
- Entirely human IgG sequence
- Human constant parts and murine variable parts (correct)
How are chimeric antibodies produced?
How are chimeric antibodies produced?
- By fusing B cells from an immunized mouse with myeloma cells to construct hybridoma (correct)
- By isolating DNA sequences coding human VH and VL from the clone
- By using entirely human immunoglobulin constant regions from mouse cells
- By isolating DNA sequences coding mouse VH and VL from human cells
What percentage of the human Ig sequence do hybrid antibodies composed of 75% of the human Ig sequence contain?
What percentage of the human Ig sequence do hybrid antibodies composed of 75% of the human Ig sequence contain?
- 50%
- 100%
- 75% (correct)
- 25%
What is used to obtain hybrid antibodies composed of 75% of the human Ig sequence?
What is used to obtain hybrid antibodies composed of 75% of the human Ig sequence?
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What is transfected into mammalian cells to produce chimeric antibodies?
What is transfected into mammalian cells to produce chimeric antibodies?
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