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Chemical Mediators in Tissue Injury

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reaction of tissue injury caused by the release of chemical mediators

inflammation

process of inflammation

protective mechanism

what are the five cardinal signs

erythema(redness), edema(swelling), heat, pain, loss of function

1st phase of inflammation. bloods accumulate in the are of tissue because of the release of the body's chemical mediators

<p>erythema (redness)</p> Signup and view all the answers

what are the chemical mediators of erythema (redness)

<p>kinins, prostaglandins, histamine</p> Signup and view all the answers

these chemical mediators dilates arterioles

<p>kinins, prostaglandins, histamine</p> Signup and view all the answers

2nd phase of inflammation. plasma leaks into the interstitial tissue in the injury sites

<p>edema (swelling)</p> Signup and view all the answers

Increase capillary permeability

<p>kinins and histamine</p> Signup and view all the answers

can cause by increase blood accumulation that results in pyrogens

<p>heat</p> Signup and view all the answers

substance that produce fever

<p>pyrogens</p> Signup and view all the answers

Study Notes

Reaction of Tissue Injury

  • The reaction of tissue injury is caused by the release of chemical mediators, leading to the process of inflammation.

The Process of Inflammation

  • Consists of two phases:
  • The first phase involves the accumulation of blood in the area of tissue injury due to the release of chemical mediators.
  • The second phase involves the leakage of plasma into the interstitial tissue at the injury site.

Five Cardinal Signs of Inflammation

  • (Not specified in the provided text, but the five cardinal signs of inflammation are: pain, heat, redness, swelling, and loss of function)

Chemical Mediators of Erythema (Redness)

  • The chemical mediators that cause erythema (redness) are:
  • These chemical mediators dilate arterioles, leading to increased blood flow to the affected area.

Increase in Capillary Permeability

  • Caused by the increase in blood accumulation that results in pyrogens, which are substances that produce fever.

Pyrogens

  • Substances that produce fever.

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