BMS 150 Quiz 4 (Week 5)

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Questions and Answers

Choose the TRUE statement regarding Charcot-Marie-Tooth disease (hereditary sensory and motor neuropathy)

Charcot-Marie Tooth disease is caused by idiopathic, multi-focal compression in a variety of nerves of the upper extremity.

Charcot-Marie-Tooth disease progresses rapidly and can cause a life-threatening flaccid paralysis.

Charcot-Marie-Tooth disease is both a sensory and a motor neuropathy. (correct)

Charcot-Marie Tooth disease is caused by idiopathic, multi-focal compression in a variety of nerves of the lower extremity

Patients with Lesch Nyhan syndrome frequently have hyperuricemia which can lead to gouty arthritis. Lesch-Nyhan syndrome is a deficiency in which enzyme?

Adenine phosphoribosyl transferase (APRT)

Xanthine oxidase

Hypoxanthine-guanine phosphoribosyl transferase (HGPRT) (correct)

Nucleotidase

Which of the following joints is the LEAST likely to be affected by gout?

Knees

Shoulders (correct)

1st metatarsal phalangeal joints

Ankles

Choose the TRUE statement regarding the diagnosis of MS.

An MS diagnosis requires more than one episode of symptoms - each episode must be separated by at least a month. Signup and view all the answers

Choose the TRUE statement about Bell's palsy.

Bell's palsy can cause impairment of taste as well as facial paralysis. Signup and view all the answers

Choose the clinical feature that is typical of an INITIAL (not late) presentation of multiple sclerosis.

Impairment of sensation in an extremity. Signup and view all the answers

Choose the TRUE statement regarding polyneuropathies.

Polyneuropathies can be both motor and sensory. Signup and view all the answers

Which of the following is the mechanism of action of allopurinol?

Inhibition of xanthine oxidase. Signup and view all the answers

The coenzyme form of which vitamin helps supply the C (carbon) needed for purine ring synthesis?

B9 (folate) Signup and view all the answers

Which of the following is TRUE regarding purine synthesis de novo?

The first nucleotide product that is built is inosine monophosphate (IMP). Signup and view all the answers

A patient presents with recurrent fungal and viral infections as well as abnormalities in her aorta that have been present since birth. Which of the following conditions best fits this clinical pattern?

DiGeorge syndrome Signup and view all the answers

Which of the following sets of clinical features are typical of hereditary angioedema?

Severe abdominal pain, vomiting, and facial swelling. Signup and view all the answers

Choose the most common primary immunodeficiency:

Isolated IgA deficiency Signup and view all the answers

Which of the following is TRUE regarding Moraxella catarrhalis?

It is usually resistant to beta-lactam antibiotics like penicillin Signup and view all the answers

Choose the bacterium that is more likely to cause otitis externa, NOT otitis media.

Pseudomonas aeruginosa Signup and view all the answers

Which of the following is an example of a secondary immunodeficiency?

Long-term glucocorticoid use Signup and view all the answers

Which of the following antigout against is good for both prophylactic acid?

Colchicine Signup and view all the answers

Which viral infection is thought to be linked to development of Bell’s palsy?

Herpes simplex Signup and view all the answers

Choose the TRUE statement regarding virulence factors of Neisseria meningitidis.

It can bleb and release endotoxin Signup and view all the answers

Which of the following organisms is NOT a common cause of meningitis?

Escherichia coli Signup and view all the answers

Which of the following types of infection best characterizes the immunosuppression due to isolated IgA deficiency?

Recurrent otitis media and bronchitis. Signup and view all the answers

Which of the following is associated with immunosuppression due to glucocorticoid use?

Higher doses Signup and view all the answers

Why does demyelination lead to death of neurons in MS patients?

Demyelination leads to conduction of fewer action potentials along the axon - this causes a reduction in neurotrophic factors which are necessary for neuronal survival. Signup and view all the answers

Which of the following types of infection best characterizes the immunosuppression due to isolated IgA deficiency?

Recurrent otitis media and bronchitis. Signup and view all the answers

Study Notes

Lesch-Nyhan Syndrome

Lesch-Nyhan syndrome is a deficiency in the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRT).
Patients with Lesch-Nyhan syndrome frequently have hyperuricemia, which can lead to gouty arthritis.

Charcot-Marie-Tooth Disease

Charcot-Marie-Tooth disease is also known as hereditary sensory and motor neuropathy.

Gout

Gout is characterized by an overproduction and accumulation of uric acid, leading to inflammation and pain.
Allopurinol is a medication used to treat gout by reducing the production of uric acid.

Multiple Sclerosis

Initial presentation of multiple sclerosis often includes vision problems, numbness, weakness, or tingling in the face, arms, or legs.
Demyelination in multiple sclerosis leads to death of neurons.

Bell's Palsy

Bell's palsy is thought to be linked to viral infections.

Polyneuropathies

Polyneuropathies are a group of disorders that affect multiple nerves.

Purine Synthesis

Folate is the coenzyme form of vitamin B9 that helps supply the carbon needed for purine ring synthesis.
De novo purine synthesis is the process by which the body creates new purine molecules from scratch.

Immunodeficiency

Isolated IgA deficiency is a primary immunodeficiency characterized by an inability to produce immunoglobulin A (IgA) antibodies.
Glucocorticoid use is a common cause of secondary immunodeficiency.

Infectious Diseases

Moraxella catarrhalis is a bacterium that can cause otitis externa, but not otitis media.
Neisseria meningitidis has virulence factors that contribute to its ability to cause meningitis.
Pseudomonas aeruginosa is a bacterium that can cause otitis externa.
Hereditary angioedema is a condition characterized by recurring episodes of swelling.

Other

Human Immunodeficiency Virus (HIV) is an example of a secondary immunodeficiency.

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Test your knowledge on Charcot-Marie-Tooth disease (hereditary sensory and motor neuropathy) by choosing the TRUE statement among the options provided.

BMS 150 Quiz 4 (Week 5)

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Questions and Answers

Choose the TRUE statement regarding Charcot-Marie-Tooth disease (hereditary sensory and motor neuropathy)

Patients with Lesch Nyhan syndrome frequently have hyperuricemia which can lead to gouty arthritis. Lesch-Nyhan syndrome is a deficiency in which enzyme?

Which of the following joints is the LEAST likely to be affected by gout?

Choose the TRUE statement regarding the diagnosis of MS.

Choose the TRUE statement about Bell's palsy.

Choose the clinical feature that is typical of an INITIAL (not late) presentation of multiple sclerosis.

Choose the TRUE statement regarding polyneuropathies.

Which of the following is the mechanism of action of allopurinol?

The coenzyme form of which vitamin helps supply the C (carbon) needed for purine ring synthesis?

Which of the following is TRUE regarding purine synthesis de novo?

A patient presents with recurrent fungal and viral infections as well as abnormalities in her aorta that have been present since birth. Which of the following conditions best fits this clinical pattern?

Which of the following sets of clinical features are typical of hereditary angioedema?

Choose the most common primary immunodeficiency:

Which of the following is TRUE regarding Moraxella catarrhalis?

Choose the bacterium that is more likely to cause otitis externa, NOT otitis media.

Which of the following is an example of a secondary immunodeficiency?

Which of the following antigout against is good for both prophylactic acid?

Which viral infection is thought to be linked to development of Bell’s palsy?

Choose the TRUE statement regarding virulence factors of Neisseria meningitidis.

Which of the following organisms is NOT a common cause of meningitis?

Which of the following types of infection best characterizes the immunosuppression due to isolated IgA deficiency?

Which of the following is associated with immunosuppression due to glucocorticoid use?

Why does demyelination lead to death of neurons in MS patients?

Which of the following types of infection best characterizes the immunosuppression due to isolated IgA deficiency?

Study Notes

Lesch-Nyhan Syndrome

Charcot-Marie-Tooth Disease

Gout

Multiple Sclerosis

Bell's Palsy

Polyneuropathies

Purine Synthesis

Immunodeficiency

Infectious Diseases

Other

Studying That Suits You

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