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Questions and Answers
What is the approximate rate of cerebrospinal fluid (CSF) production per day?
What is the approximate rate of cerebrospinal fluid (CSF) production per day?
- 150 ml/day
- 550 ml/day (correct)
- 85 ml/day
- 60 ml/day
Which of the following is NOT a function of the cerebrospinal fluid (CSF)?
Which of the following is NOT a function of the cerebrospinal fluid (CSF)?
- Supplying nutrients to the CNS
- Physical support and protection of the central nervous system (CNS) from trauma
- Regulation of body temperature (correct)
- Transport of biologically active compounds
Which body part is responsible for the production of cerebrospinal fluid (CSF)?
Which body part is responsible for the production of cerebrospinal fluid (CSF)?
- Choroid plexus of brain ventricles (correct)
- Liver
- Heart
- Kidneys
What is the total volume range of CSF in adults?
What is the total volume range of CSF in adults?
Which medical condition would require CSF analysis for diagnosis?
Which medical condition would require CSF analysis for diagnosis?
Besides supplying nutrients, what other function does the cerebrospinal fluid (CSF) serve?
Besides supplying nutrients, what other function does the cerebrospinal fluid (CSF) serve?
What is the rate of CSF formation in adults per day?
What is the rate of CSF formation in adults per day?
Where is CSF collected from by lumbar puncture?
Where is CSF collected from by lumbar puncture?
What is the normal range of pressure for collecting CSF from an adult?
What is the normal range of pressure for collecting CSF from an adult?
What is the ratio of serum to CSF protein concentration?
What is the ratio of serum to CSF protein concentration?
What is responsible for maintaining the difference in Na+, Cl-, and Mg2+ levels between serum and CSF?
What is responsible for maintaining the difference in Na+, Cl-, and Mg2+ levels between serum and CSF?
Which condition does NOT lead to increased CSF protein levels?
Which condition does NOT lead to increased CSF protein levels?
What is the main source of energy for the brain?
What is the main source of energy for the brain?
In which condition would you expect to find yellow-colored CSF?
In which condition would you expect to find yellow-colored CSF?
"CSF may clot if the ratio of blood to CSF is high." What is usually responsible for this clotting?
"CSF may clot if the ratio of blood to CSF is high." What is usually responsible for this clotting?
"Blood and CSF glucose equilibrate after 4 hours." What does this imply for CSF glucose level at a given time?
"Blood and CSF glucose equilibrate after 4 hours." What does this imply for CSF glucose level at a given time?
Cerebrospinal fluid (CSF) is primarily composed of about 90% water.
Cerebrospinal fluid (CSF) is primarily composed of about 90% water.
The rate of CSF production is approximately 500 ml/day.
The rate of CSF production is approximately 500 ml/day.
CSF turnover rate is approximately 2.5 times a day.
CSF turnover rate is approximately 2.5 times a day.
CSF functions include CNS waste management and physical support & protection from trauma.
CSF functions include CNS waste management and physical support & protection from trauma.
CSF analysis is required in the diagnosis of autoimmune disorders like Parkinson's disease.
CSF analysis is required in the diagnosis of autoimmune disorders like Parkinson's disease.
The total CSF volume in adults typically ranges from 100 - 200 ml.
The total CSF volume in adults typically ranges from 100 - 200 ml.
CSF glucose concentration is 60% of serum.
CSF glucose concentration is 60% of serum.
The ratio of serum to CSF protein is 200:1.
The ratio of serum to CSF protein is 200:1.
CSF may clot if the ratio of blood to CSF is high.
CSF may clot if the ratio of blood to CSF is high.
CSF color can be yellow due to jaundice and high protein levels.
CSF color can be yellow due to jaundice and high protein levels.
CSF viscosity is equal to water in normal CSF.
CSF viscosity is equal to water in normal CSF.
CSF glucose level reflects the blood glucose level during the past 5 hours.
CSF glucose level reflects the blood glucose level during the past 5 hours.
The main source of energy for the brain is glucose.
The main source of energy for the brain is glucose.
The composition of Na+, Cl-, and Mg2+ in CSF is same or greater than serum levels.
The composition of Na+, Cl-, and Mg2+ in CSF is same or greater than serum levels.
CSF analysis involves physical examination, biochemical investigations, and microscopic and microbiological examinations.
CSF analysis involves physical examination, biochemical investigations, and microscopic and microbiological examinations.
CSF proteins originate from serum and reach the cerebral space by endocytosis across the capillary endothelium.
CSF proteins originate from serum and reach the cerebral space by endocytosis across the capillary endothelium.
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Study Notes
Cerebrospinal Fluid (CSF) Production and Composition
- CSF production rate is approximately 500 ml per day.
- Total CSF volume in adults typically ranges from 100 to 200 ml.
- CSF is primarily composed of about 90% water.
Functions of Cerebrospinal Fluid
- CSF serves multiple functions including:
- Waste management for the central nervous system (CNS).
- Physical support and protection from trauma.
- Nutrient supply—CSF glucose concentration is 60% of serum glucose.
CSF Analysis and Diagnostics
- CSF analysis is crucial for diagnosing conditions such as autoimmune disorders, including Parkinson's disease.
- CSF analysis includes physical examination, biochemical tests, and microscopic/microbiological evaluations.
Pressure and Formation Characteristics
- CSF is collected via lumbar puncture.
- Normal pressure range for collecting CSF from adults.
- CSF turnover rate is approximately 2.5 times a day.
- CSF proteins originate from serum, reaching the cerebral space through endocytosis across capillary endothelium.
Electrolyte and Protein Concentration
- The ratio of serum to CSF protein concentration is 200:1.
- Maintenance of differences in Na+, Cl-, and Mg2+ levels between serum and CSF is crucial for proper CNS function.
- Certain conditions can lead to increased CSF protein levels, but specific conditions do not.
CSF Appearance and Glucose Dynamics
- CSF may appear yellow due to jaundice or elevated protein levels.
- CSF clotting can occur if the blood to CSF ratio is high.
- Blood and CSF glucose levels equilibrate after approximately 4 hours, indicating that CSF glucose reflects blood glucose levels from the previous 5 hours.
Energy Source for the Brain
- Glucose is the main energy source for the brain, crucial for its metabolic processes.
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